ID   F0Z1T2_9CLOT            Unreviewed;       908 AA.
AC   F0Z1T2;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-MAY-2011, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=Pyridine nucleotide-disulfide oxidoreductase family protein {ECO:0000313|EMBL:EGB91832.1};
GN   ORFNames=HMPREF0240_03069 {ECO:0000313|EMBL:EGB91832.1};
OS   Clostridium sp. D5.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=556261 {ECO:0000313|EMBL:EGB91832.1, ECO:0000313|Proteomes:UP000003978};
RN   [1] {ECO:0000313|EMBL:EGB91832.1, ECO:0000313|Proteomes:UP000003978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D5 {ECO:0000313|EMBL:EGB91832.1,
RC   ECO:0000313|Proteomes:UP000003978};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Earl A., Feldgarden M., Gevers D., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A.M., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA   Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA   Heiman D.I., Hepburn T.A., Howarth C., Jen D., Larson L., Mehta T.,
RA   Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T.D.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C.,
RA   Sibley C.D., White A.P., Crowley S., Surette M.G., Strauss J.C.,
RA   Ambrose C.E., Allen-Vercoe E., Haas B., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Clostridium sp. D5.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|ARBA:ARBA00001917};
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DR   EMBL; GL870815; EGB91832.1; -; Genomic_DNA.
DR   AlphaFoldDB; F0Z1T2; -.
DR   eggNOG; COG0493; Bacteria.
DR   eggNOG; COG1143; Bacteria.
DR   eggNOG; COG4231; Bacteria.
DR   HOGENOM; CLU_014111_0_0_9; -.
DR   Proteomes; UP000003978; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.30.70.20; -; 1.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF00037; Fer4; 2.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003978}.
FT   DOMAIN          296..325
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          846..875
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   908 AA;  99627 MW;  7F1ABD1AF2825308 CRC64;
     MAERGKELGM AEERTLILKL GQKITDRIGH KVTVDDPEYW GLACVVTDEM AEVALAMKVR
     KPASAAEIAK KCGKPLKRTE ELLQEMSVIG LLEYNWENAD RHKQYILPMF VPGCAEFMNM
     NLEQVEEHHE VARFFERMSR LPLEKVTPMV PPGGAGIGMH VIPVEKAIPT EQKSVSVEHI
     SHWVQKYKGK YAVGACSCRR SRRIQGEGCG HLEEDMCIGV GDMADYLVET GKGRYIDEAE
     VMEILQRAEE NGLVHQITNI DGEDKIFAIC NCCVCSCYAL RTSQLFNTPN MSRSAYIAKV
     NTDNCVACGQ CVEYCPSGAA KLGQKLCTKN GPVTYPVQEL PDAVKWGPEK WNENYRDENQ
     INCYDTGTAP CKTNCPAHIA VQGYLNMASQ GRYLDALKLI KKENPFPAVC GSICNRRCED
     ACTRGEIDQA VAIDEVKKFI AMQELNADTR YIPPMVNQIG KPYPQKIAVV GAGPAGMSCA
     FFLAQKGYPV TVFEKHRQPG GMLTHGIPGF RLEKEVVDAE IAVLREMGVE FKCGIEVGKD
     ITLDELRTQG YQAFYLAIGC QGGRRAGIPG EEYEGVQTGV DFLHMVNTDE NIRLTGRTIV
     VGGGNVAVDV ARSAVRSGAS GTAMYCLEDQ NSMPAAADEV AEAQEEGITV NHGWGPKEIL
     GENGRVTGVV FKKCVAVTDA EGRFCPRYDE EDCITVECDN VLLSIGQSII WGSLLEGSRV
     ELGRGNGAVA DPLTYQTGEP DIFVGGDVYT GPKFAIDAIA AGKEGAVSIH RFVHDGQSLT
     IGRNRREFKE LDKKNLDIPD GSYDRAGRQA PGHSTGVHAA STFRDTRLLF TEEQVKAETA
     RCLGCGATVV DENRCIGCGV CTTKCEFDAI HLSREIPEAS RMMKSEDKMK AILPYAAKRQ
     IKIIRSKK
//