ID F0Z675_DICPU Unreviewed; 860 AA.
AC F0Z675;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase {ECO:0008006|Google:ProtNLM};
GN ORFNames=DICPUDRAFT_25009 {ECO:0000313|EMBL:EGC40549.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC40549.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
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DR EMBL; GL870941; EGC40549.1; -; Genomic_DNA.
DR RefSeq; XP_003282885.1; XM_003282837.1.
DR AlphaFoldDB; F0Z675; -.
DR STRING; 5786.F0Z675; -.
DR EnsemblProtists; EGC40549; EGC40549; DICPUDRAFT_25009.
DR GeneID; 10503345; -.
DR KEGG; dpp:DICPUDRAFT_25009; -.
DR eggNOG; KOG0248; Eukaryota.
DR eggNOG; KOG2283; Eukaryota.
DR InParanoid; F0Z675; -.
DR OMA; NFHTGMF; -.
DR OrthoDB; 9895at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR CDD; cd14497; PTP_PTEN-like; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR12305; PHOSPHATASE WITH HOMOLOGY TO TENSIN; 1.
DR PANTHER; PTHR12305:SF100; PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 3-PHOSPHATASE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT DOMAIN 18..189
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 103..177
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 194..330
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 403..502
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 493..624
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 758..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 97533 MW; C404035AAF4114D1 CRC64;
MYNSIVKAVR KTISADKNRF ENEEYDLDLT YITERVIAMS FPADGVESAY RNSIYDVSKM
LNENHKNNYL IYNLSERKYD YSLFNKSVVD WCGFPDHHAP PLGLLFKIVK TIYDWLGKDP
LNVVIVHCMA GKGRTGTVIS CLLQYGGLFD SASDAMRYFA VKRSNNNYGI TGPSQIRYTQ
YFSELYLGGK DLNPSPVFLK SISMVTIPKF FLGPLKQGIC PVLNIYSATQ KGVRIFTSAP
IEGDTKETRT YQSGNATIIF EVRKIVRGDI LLVFSHITPF YRVEQICRAN FHTGMFSMPT
LILTKSDLDG ADGDKRFSND FNLKLEFQEV VNNNSNGSQS PLIEASTSQS ILEYQKEIKK
EIKWIRHEAI KKDPKNGSVF FLPKNNSEKI KQAKDIASKQ GTFGVHSGFL LKKGHNFKSW
RRRWFVLKDN LLSYYKSPKD TTPAGVIPVN EILDISIKCE ISQQEGHDYC FEIITHKASY
LISAENEKDL EDWTEILNSA IKMIQSTGRL FIEILEAKYE PNVILQSLTD PSAIIDINDH
PIDIITYLTI HLGKKRDTTS HKSMLFNPIF QYAGDFAIYN EPCDLVVSLW VRSSVQNIKD
TLAAEFVLNH KQLMSSYNTE WREFNRIKSN LLTNMSLKFG SVYRCESDLS LHENALGSLQ
SPNQFSNSPG SFNSNENRKS IIHQSVSFNH SLYQQTPNNN NNNIDNSKII SNNGGLSNSL
NFNSISNNNN NNNLSTNVST SAPSTNYIFL AKSREENHRA NSMNSNNNSN NNKSLNNSNE
TNSNKNNNSS SLDKTTAMNS YGFSFDGDDE DKLIKALENQ LNDTQDDDEL ISDLQSKLDY
FEDIAPNEDD SLSEFKIINK
//
