ID F0ZAI4_DICPU Unreviewed; 348 AA.
AC F0ZAI4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=O-methyltransferase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DICPUDRAFT_52923 {ECO:0000313|EMBL:EGC39053.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC39053.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
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DR EMBL; GL870964; EGC39053.1; -; Genomic_DNA.
DR RefSeq; XP_003284403.1; XM_003284355.1.
DR AlphaFoldDB; F0ZAI4; -.
DR STRING; 5786.F0ZAI4; -.
DR EnsemblProtists; EGC39053; EGC39053; DICPUDRAFT_52923.
DR GeneID; 10506079; -.
DR KEGG; dpp:DICPUDRAFT_52923; -.
DR eggNOG; KOG3178; Eukaryota.
DR InParanoid; F0ZAI4; -.
DR OMA; CTEPWTW; -.
DR OrthoDB; 5230501at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IBA:GO_Central.
DR GO; GO:0019438; P:aromatic compound biosynthetic process; IBA:GO_Central.
DR GO; GO:0031148; P:DIF-1 biosynthetic process; IEA:EnsemblProtists.
DR GO; GO:0032259; P:methylation; IBA:GO_Central.
DR GO; GO:0010623; P:programmed cell death involved in cell development; IEA:EnsemblProtists.
DR GO; GO:0045595; P:regulation of cell differentiation; IEA:EnsemblProtists.
DR GO; GO:0031288; P:sorocarp morphogenesis; IEA:EnsemblProtists.
DR GO; GO:0031149; P:sorocarp stalk cell differentiation; IEA:EnsemblProtists.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:EnsemblProtists.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 17..99
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 121..326
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 256
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 348 AA; 39912 MW; D01594D22C0DC71E CRC64;
MISNDDYLMD IKDRDFLLEV AIGYTKSISL SIALKLNIPQ LLQSGPKSCE ELAKITNTHS
ENLYRLLRTL STIGIFIEDE EKDGVFSNSR LSLLLTNTSN SSWINNIYLQ SHPNVIKSFM
YLEKTIETGE SHGMTSQGFS SAWEMFELDT KLKSYFHNTM TCFTQDEINT ILKYIDFNEF
ESVVDLGGST GVLLKAIAKS KNGIKVRSFT NFDLPHVISQ NKQDCEDDRY SDVSGDFFIL
DSIPKADCYT LKFILHMFND DKVLSLLENL KRSIDKNGKV YIFDHIVQPK NTPSAPFYFD
LQMILNFNGK ERSVKEWKDV IDRSPFKINS IRVLSDNKRM SLIELSLK
//
