ID F0ZJF2_DICPU Unreviewed; 533 AA.
AC F0ZJF2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=AICAR transformylase {ECO:0000313|EMBL:EGC35910.1};
GN ORFNames=DICPUDRAFT_47411 {ECO:0000313|EMBL:EGC35910.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC35910.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-
CC 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route):
CC step 1/1. {ECO:0000256|ARBA:ARBA00004954}.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP
CC from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step
CC 1/1. {ECO:0000256|ARBA:ARBA00004844}.
CC -!- SIMILARITY: Belongs to the PurH family.
CC {ECO:0000256|ARBA:ARBA00007667}.
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DR EMBL; GL871043; EGC35910.1; -; Genomic_DNA.
DR RefSeq; XP_003287564.1; XM_003287516.1.
DR AlphaFoldDB; F0ZJF2; -.
DR STRING; 5786.F0ZJF2; -.
DR EnsemblProtists; EGC35910; EGC35910; DICPUDRAFT_47411.
DR GeneID; 10500525; -.
DR KEGG; dpp:DICPUDRAFT_47411; -.
DR eggNOG; KOG2555; Eukaryota.
DR InParanoid; F0ZJF2; -.
DR OMA; IKHNNPC; -.
DR OrthoDB; 3486892at2759; -.
DR UniPathway; UPA00074; UER00133.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003937; F:IMP cyclohydrolase activity; IBA:GO_Central.
DR GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IBA:GO_Central.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IBA:GO_Central.
DR CDD; cd01421; IMPCH; 1.
DR Gene3D; 3.40.140.20; -; 2.
DR Gene3D; 3.40.50.1380; Methylglyoxal synthase-like domain; 1.
DR HAMAP; MF_00139; PurH; 1.
DR InterPro; IPR024051; AICAR_Tfase_dup_dom_sf.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR011607; MGS-like_dom.
DR InterPro; IPR036914; MGS-like_dom_sf.
DR InterPro; IPR002695; PurH-like.
DR NCBIfam; TIGR00355; purH; 1.
DR PANTHER; PTHR11692:SF0; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC; 1.
DR PANTHER; PTHR11692; BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH; 1.
DR Pfam; PF01808; AICARFT_IMPCHas; 1.
DR Pfam; PF02142; MGS; 1.
DR PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR SMART; SM00798; AICARFT_IMPCHas; 1.
DR SMART; SM00851; MGS; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR SUPFAM; SSF52335; Methylglyoxal synthase-like; 1.
DR PROSITE; PS51855; MGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..143
FT /note="MGS-like"
FT /evidence="ECO:0000259|PROSITE:PS51855"
SQ SEQUENCE 533 AA; 58339 MW; 821AF62CCD40FC8E CRC64;
MQALLSVYNK TGIVEFSKIL SSKGFNLIST GGTFKSLADN GLKVQQVSDV TEYPEMLDGR
VKTLHPKIHG ALLARPELSH HQADLTKYNI KPIKIVVVNL YPFVETISKP DVTLEDAIEN
IDIGGHTLIR ASSKNFQNVL IIVDPTDYKW IGERIEQTGI ESITLEERKK LAVKALQHGC
QYDAAVTQYL AGVELPTEAK SIENIKTPSN ANVEFPNTFV PLYEKKNDLR YGENPHQKAA
LYSCPNSGGI ANAKSLHGPA LSYNNILDGD AALKAVREFA DTACVVIKHT NPCGLAVHKD
QTEAYRRAFN GDPKSAYGGI VGFNRKLTLE SATAMKGIFY EVIIAPEYDP EALALLQKRE
KLRVLLVPEA ATQQAFTQPD IRTITGGALL QSPNPIVLGS LEEATKNWKV VTDAKPTEQQ
MRDLLFAWRV SKHVKSNAIV LTKDETIVAI GAGQPNRHQS VDICMKVGGE KAIGSALASD
AFFPFADSID LAHQGKIGCI VQPGGSIRDQ EVIDAANKYN IPMVFTGNRN FLH
//