ID F0ZRC6_DICPU Unreviewed; 340 AA.
AC F0ZRC6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:EGC33503.1};
GN ORFNames=DICPUDRAFT_80730 {ECO:0000313|EMBL:EGC33503.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC33503.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR EMBL; GL871139; EGC33503.1; -; Genomic_DNA.
DR RefSeq; XP_003289977.1; XM_003289929.1.
DR AlphaFoldDB; F0ZRC6; -.
DR STRING; 5786.F0ZRC6; -.
DR EnsemblProtists; EGC33503; EGC33503; DICPUDRAFT_80730.
DR GeneID; 10504322; -.
DR KEGG; dpp:DICPUDRAFT_80730; -.
DR eggNOG; KOG0785; Eukaryota.
DR InParanoid; F0ZRC6; -.
DR OMA; WVFFREN; -.
DR OrthoDB; 143577at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006102; P:isocitrate metabolic process; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR004434; Isocitrate_DH_NAD.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR NCBIfam; TIGR00175; mito_nad_idh; 1.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 13..332
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 340 AA; 36560 MW; A60D278C297A83E0 CRC64;
MVLRNYSTQP IQKVTLIPGD GIGLEISESV KKVFAAAKVP IEWETVVVDA NTGISKEVAE
SIRKNKIGLK GPISTPIGTG HQSLNLGLRK TFGLYANVRP CLSIPGHKTR YDDVNTVVIR
ENTEGEYSGI ENMPVKGVAQ SIKIITKEAS TRIANYAFQY ALANGRKKVT CIHKANIMKQ
SDGLFVKSCR EVATRYPTVK YEELTIDNNC MQLVLNPAQL DVMVLPNLYG DIVSDLCAGL
IGGLGLTPSG NIGENGTAIF EAVHGTAPDI AGQNKANPTA LLLSGIMMLR HLGLNTHANK
IESAVLTTLG EGKIMTGDMG GKSSCTDYTD ELCRKIQNAN
//