ID F0ZT67_DICPU Unreviewed; 3043 AA.
AC F0ZT67;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=Non-specific serine/threonine protein kinase {ECO:0008006|Google:ProtNLM};
GN Name=DHKG {ECO:0000313|EMBL:EGC32865.1};
GN ORFNames=DICPUDRAFT_155144 {ECO:0000313|EMBL:EGC32865.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC32865.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC protein kinase family. ROCO subfamily. {ECO:0000256|ARBA:ARBA00008171}.
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DR EMBL; GL871170; EGC32865.1; -; Genomic_DNA.
DR RefSeq; XP_003290617.1; XM_003290569.1.
DR STRING; 5786.F0ZT67; -.
DR EnsemblProtists; EGC32865; EGC32865; DICPUDRAFT_155144.
DR GeneID; 10508089; -.
DR KEGG; dpp:DICPUDRAFT_155144; -.
DR eggNOG; KOG0519; Eukaryota.
DR InParanoid; F0ZT67; -.
DR OMA; CAISPNA; -.
DR OrthoDB; 197480at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR43642; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR PANTHER; PTHR43642:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE G; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 208..709
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 2242..2505
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 2915..3033
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 88..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1844..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2069..2100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2388..2423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2613..2645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2743..2784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2806..2837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2390..2406
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2743..2776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2965
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 3043 AA; 341087 MW; EE27976C6696B036 CRC64;
MSNFVWLQDY CIGEKIQEEK VFSIYRASLT NNSYIFPLPS TTFNNSLISS TPIIYENSVV
NKNYTLNNEN SYLNINNSNN EIININNNNN NYNNNNNNNN NNNNNNNNNN NINIKENSIL
NSNSFSDTDL SYKSKTIKFF NSENEQQQAT NKRVSTKFIQ QQSFTSPSIA TSTININPLT
NNIISPNNNG LNNINNNPSL NIINNIDMDL VSPPPLGSLS PLGFKQSQIL GRKPTEFVLN
NNFVLLKILN YKYPPVELIT IFQREYFILS YLSEFDGILK LIRTQSEYGN IVALIFEEAG
FKSLTAYYNL SSLNSQSFIH SSSTSPSIKS TIHDISKPFN LNSSNSSNSN STTQTPNQAS
TQPPQQLNPS CSPLIITSQP SLLNSLNNIV NNNNPTSSNS INMNIDGSNV NNIVNSQNNT
LNTTTTINNI NNNNYMPSSP ILGSNKINNK RRASLTPTTT PLSASPILYN TKKFGDIDTN
TFLNIAIQIA TILETIHSKG CIHRDIRPSN IYLNTSCKVK LANFQFSILK KSSSFFKNLN
SNNNSNFNDQ DSDSFHNGNF NDDSCSHSMS SGVGEGYEDN LFNNNFNYDD ESICQLFKNP
PDLSRFSTST FYYISPEDTG RTQHSVDERS DLYSLGITFF ELLTGRVPFQ STDLSELIHS
HLAKKPPNVS DLNSNTPLIL SKIVNKLLQK SPDDRYNSSY GLKKDLEMVK LQLSLDNQRN
IDFQLGTFDI INRPIISNEL YSRKKELNII LSTIKKVSKG GKEFIIVSGL SGVGKTSLIN
ASCKKSIVKI RFIQGKFDQY NKSPYSAIIE ALSQLVNLIL ASSPLELEFY KDRLLRALGP
NIGVISDVIP KLELIVGPHN KPLPLPSSES QNRFDLAFKD FLRVFAEEGQ PLVIFLDDFQ
RADPSSYRLI KLLMENNSNN NNSISSSTGV SNSNNTNNGY SQKGLNYLLV IGAFRENEVN
ELNQQDFQDL SSISTKIVLK KLELKDVNLM VSSTLHTLPH ETISLSQVVL SKTHGNPFFI
IQFLKTLFNE NLVFFSTQEE KWVWDIEKIQ KREFTDNVVE FMVETLKQLD PKAQKVLHLA
SCIGNSVDLE MLASVAELSQ EETLKILTPI LSRDLIVNVH DKRYNFVHDR VQQAAFSLVV
LREEKKQIHL KIGRILYKNY LNKQTNQPIL QLNNHHNHSS QPSTIITIFD ILNQYNFGID
LIDTLEERLK LSLLNYEAGK KAKSSTAYNY ANQYFQIALN LFPDLEETWS EHYQLLFNIF
LEKSQSEFMV GNFEESDRLI EEALIHAQMD EHIGQVTALR VKQYTLLTRF DDCLAMSVEF
LKSQGVLIDP NVTVDELRKD YEAFKEKLGD ESLSTVMNRL HQNIKPTPVV ESCIQLMSIM
IPSLFLNNME ILSSLLMKFA EYTLENGISS WSSTGFAMFG LVVSIGYFDD FKLGYQFGKY
AMSLKEEFSE QVGSKGMVTL LYSGYIHHLE NHLSTSIPIC KQAFLESIEC GDLGCACYCS
VNLILHRLLI GSPLEETFQL SKQYSNYIEQ YYFKPMYQVV ISLQNFILEL MGTDIISEQQ
SSTFLFNSEW DIDAFEFELD STPDVHCPIA FYYIMKIQHC YYFSDFETAW KSVLRTEQSI
VGIFGHTHLL AVLYLFKCLT IFALYPTLTQ EERNDRMEMV NVYRAKLEGL ANQSWENFGS
HLMILRAELE RLNGNYEEAM EYYSEAIVLA QQFKYQQNEA LANELASRMY IQIKKFAVAK
AYLIEAHMCY RSWGALRKSN LLELEFPHIL CQTTGTLMNP TKRVKRIESL FSTNYVSFNN
SNNKETSSIS NVNNNISNSS SCLSSSSSSS LYSSSSSSLQ TTILPSSPLN KNSIPPPITT
PFTSSSNISN SLGMSSMKTS VNSVIRSNST GSSGTCSSSS SSCSSNTNSS CSSNGLYFGN
LIGNSNNSNE PSLSIRRRSQ DGTFTTKNVF RYPVDAVDLC SVITVSNSLA EEIYFDRLLK
RLMKVVIKNA GASRGFLLLI EDKITKELFI NPSNGNHTLL GDLSVAASAL VYNEKVLVEV
FINNTSQTLS TAPSTPIINS SSYNLASSST STTNTSGNLN KSSNNIPNSN NSNNSNSNGY
SGKLNNIIRN DSLNEDGTWN MCISMINYVR RTQAPLLITN AVEDNTFADD SYIKKRNPKS
ILVLPIVYQG NLVSILYLEN NFATGAFTHG RMEILNLLSS QIAISFQNAR LFLKSNHLAN
QAFLAKEDAE KANKAKSDFI SNMSHEMRTP LNHIIGAIEL LKGFPSTNDQ KELLAISQQS
SESLLFMVNN ILDLSKVEQG KTKLNLTSFN IVNFLEDIIC AISPNAHSKG LYIGLFINPC
FSKIPVNGDV NILRQIIVNL LTNAIKFTEK GEVYLKLNLS LNNNVDRSPI NEEEEEEEGD
EYEEMQNEDT INLKKRNNNK RKGSPSNYVI NIEVSDSGIG IKQSDFGKLF QRFSQIEVGS
SRAYDGTGLG LSICKQLVNL MKGDIGIRSK IGEGSVFHFT VELSKSYDES MSNKYHLPSE
LTQNTKITIF EENKTICDQI KTLCKSNGLN EINTINQKFS LELLSDCLDT LKPISSPKLQ
SSCGGSSSAT ILSPKLLSPK LLSPRTPLSI NGCTTTNMNS LSPKNPSRSP SPSFSSISPS
FSSSPPNKEI IIIGLPLNFT EENILTLVEN TKTITYSAYI NKKGNISIAS NVNKFEFVFV
THILLSVSSR EILNQASIHI VNRPIKMKAF HRTLMKILDS NSKSHNSSYM SSPNISNNLH
TSVNGTNTNG LNNPDDNHKH QQFKFQKQLS DSNICYTSSK KLIQNHQQQQ QTKQQEQPQE
QQYQQKKQLK QETQTIPESE FENSLVIGSS CATSNTTTTT LTNDTEVTII SNSAAGEENN
NTSSSISISS SIVCSSSNNI VIEPIIKVVE KISPSILVVE DNELNANILF RMLQKLGIKD
PDLALNGLEG VKKAKNEEYD LILMDIQMPV MDGYEATTKI RKEEGNKKHT PIIAMTASAM
NGQKEAMLSA GCDDFFSKPF TLKDLQGKIF KFLNYTPPTI QPK
//
