ID F0ZWR7_DICPU Unreviewed; 2584 AA.
AC F0ZWR7;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN ORFNames=DICPUDRAFT_156510 {ECO:0000313|EMBL:EGC31602.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC31602.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL871242; EGC31602.1; -; Genomic_DNA.
DR RefSeq; XP_003291860.1; XM_003291812.1.
DR STRING; 5786.F0ZWR7; -.
DR EnsemblProtists; EGC31602; EGC31602; DICPUDRAFT_156510.
DR GeneID; 10505616; -.
DR KEGG; dpp:DICPUDRAFT_156510; -.
DR eggNOG; KOG3687; Eukaryota.
DR InParanoid; F0ZWR7; -.
DR OMA; IRWFTSC; -.
DR OrthoDB; 20915at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 2.
DR Pfam; PF02145; Rap_GAP; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT DOMAIN 2316..2569
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1794..1816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1896..1934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1975..2018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2110..2166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2244..2277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2442..2470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1453..1487
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1557..1584
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1997..2018
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2119..2166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2244..2263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2456..2470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2584 AA; 291430 MW; BFEC15B9EFD85CFD CRC64;
MNKNNSNTTN SPMNNYSSGS NSGGGSGKYE NTSSPKTTVL KKIKDMFGSS NYQSNNQNNN
NNNNNNNNSN NNSNNINNNE INEENDYSYN SGSLSHSQSS GNLSLLNIIN NNNQYSINDI
ETINDRLRAE LRNNKYLTLG SRVTFLKEFC DYIKFFRMEN IEQVWNCASD LVEDNKPIEA
QIVAMQMMLA LIESNYGILG DLRSIFYQII TDNKSINILQ LSNSNNNNNN NSNNNSQQSQ
QLVNNHNTTT SINNANSSPS SSILSNSHKS LPLINYHAQF NQQQQQTLLQ LASSPSTNNL
STSLPHHSYL QQEINILSPS SSTSNIISPP QQLSSSHNQL PTSSPQPIVN EKSNLSSSHN
QLPSAASPSS NIASPSSNIA SSHLSTKSFQ EQLTQQIQQQ QLQQQQQSNL ILLNSKIKAF
GSLIKQGKDM IPFENEVIQV LITWLSIMSN HYRNSSNISN TGFDDLLVMI ENIIKNGSSI
LTEGDIASLI DAMCILCNST SSIGIIESCL NFFNIITKMV VIPPSCVSMV IGSLCRTVNI
ESACNSSWET MQSLLEKYGN QGIHSLCSIL NDPQNRNTIN LLRGAVFFIG MSIWGSQRIS
SLHISAAVVL PSLYNSLSGR QEIIAYEVIL ALRRLVKKYG GNLNVEWDLI FLIFERMQSL
LVNNTDQENA NNSLFKVLRD TVSYIEELEE KQCFEGSKSG LFEISAPYFK YKTEDAILMA
IDKQKTKIHP SHALWIKKMS LLIDLFYRKD PRTRIRKRIL LSIRQIYFQF QQIYGEEILE
KIVAPTFIDI YRDRDVHIRT YGIEILIEIL TKSAGQLSSS VFHQLLSILE RSIMISSHKE
MIVYLEISKI SIRGLIQIFK NQLFHSPPQL SLDLWSLILS QISNDSLIIR REVLYCISNL
SSNKWYQLIF QNHSSLFLHF SQANNFLSDL SKILTKSPMS PRSPRSIELN NDNNSNNNNN
NNNNNNNESD NQNFQNVEED LDDISSNGSV EDNHNTNQQQ SQTSIHQTAA TENQALSLST
SSLPNPPTVK KQYNPNDGGC FSNINIWNAL LERLVKETNY ELYLMILDII SNQLKNRYIL
LGLENETQSL VNLLSKSLSD RTLGICINDF QNLENNKKET LYILSLEILC NLIAYQNPSS
PFEKCQNSIS NMITTLTFCL GQKWSNENRS KVHSICLNGL MISAVDFPFK ITLKHIQNIT
KSLYSILTSS NTNKETYFTI LQYLNLLVSI DNSSIGLSQQ LPFETLTFIF KLIIQFIDKS
RYSSLIIVVA FQSLIRWFTS CTQSTRTLLV RNIIKTLDSQ LREKKDSLLI DIAIELLNRY
IHTDIDPYHY PIKHSSPLFQ GSQTKTWFQN SSPTLITIRT GRLGWSEVTL RKATGCVSWL
MRFQNNFNPL LSSNNLNLYN ELSMLNDYNQ QQQQQQLQQQ QQQQQQIDQI LQQKIIQYQI
NNQQSSLNQN NIYLQQQQQL QLQQQQLRLL QQQLQAQQQQ TSQLIVEQNF NEKSIQNFQP
YPTSSPLQQQ YYEPPSFKTF INRRNEPSTP SSSPISGSGE LYQNINTGQI SFAKLQKQKS
QQKFQLYQQQ QQQQQQQQEK QQQKSLVKDT LDEIKDSDKI IDSLNKLMKK LESSSSKANT
TESAKEQSYL SKINLSHHRS NKTSPHNEND SSITKLGLSF LPKDSTSLSS NKNTPTIQSS
NDIQLLSTNF LISPMIQPID KKNDNQQNEL KSSNIPLLTL ESKNNNSSNN NNNNIREVGL
CYGENYLAEA KVPKLPLDNT NTKICGSGYN YDNSSVNSNE NLFLNSNLES PYKLSYDSNT
DENSSSTPTS YNNNNVHSLS RYYPPLPSYD DDEELLSFFS SSSPTQMVSS SSDLNSQVKL
NLSAQLLLHA DPSSPNLENI NHSFLFDDYQ QSQQPTIPIE IPGEGSDNNG NSNSGSGKNN
PNKNNITQKT KNSSNKVVLL NSNTNSLASS NSSLTKPESE IFSLSVENDD LDQYYNYDNG
NAENWKPSRS KKASKPKKSS NNSVGDKQHN PIHLSTSPSI SSIASKINEL EICSLGSTAT
RNECLVKSTS FNIESSSSSS NQQAHLISPI PILAQTPSQS PLGSVKQNQL LLTPQKINIS
ESAFNILSEK EKESQLEKPS ETNTNTNTNT NNTNINFSSS FNSQQIQNNK PSSPLNQSTP
SIIKQDSSGS LYHPIIRSSS QQSLLTKKTN NIIANTTSIN ASPSNPKSYV NSKALNIEYL
LSTSLNNNSN IINNNMNMNN NMNNNNITAI SPSSQFGSPH SGLSPPHSPS PPPIQQEPHE
LDYTILDPSI VFYHLHQFSG DITTEIKMGN SFERSLSVLD HTFCSETYKF GILYCAADQN
TEEQILSNSK GSPRYHQFLN LMGETIRLSD RLDVYPGGLD RTGKTDGEYS IYWKDRISQV
IFHVATMMPS IDTDKLFTNK KRHIGNDYVN IIFSESPNLF NTHSNDDDDD DNSSHYILNQ
HSSSSSSSDD EKLSKIISGQ FNFVLIVVNP LEDGWYRVEI KKKKDIPIFG PIHNNQIISA
KSLPTLITQT AINANLISMQ FDGKVDFISN LEERLKQIKT IKERFAQDEE NSWLDLISLK
KINK
//
