ID F0ZY22_DICPU Unreviewed; 896 AA.
AC F0ZY22;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN ORFNames=DICPUDRAFT_50351 {ECO:0000313|EMBL:EGC31151.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC31151.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
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DR EMBL; GL871273; EGC31151.1; -; Genomic_DNA.
DR RefSeq; XP_003292317.1; XM_003292269.1.
DR AlphaFoldDB; F0ZY22; -.
DR STRING; 5786.F0ZY22; -.
DR EnsemblProtists; EGC31151; EGC31151; DICPUDRAFT_50351.
DR GeneID; 10507973; -.
DR KEGG; dpp:DICPUDRAFT_50351; -.
DR eggNOG; KOG3686; Eukaryota.
DR InParanoid; F0ZY22; -.
DR OMA; HVAPMIP; -.
DR OrthoDB; 5264at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblProtists.
DR GO; GO:0031252; C:cell leading edge; IEA:EnsemblProtists.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0031589; P:cell-substrate adhesion; IEA:EnsemblProtists.
DR GO; GO:0007163; P:establishment or maintenance of cell polarity; IEA:EnsemblProtists.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:EnsemblProtists.
DR GO; GO:0043520; P:regulation of myosin II filament assembly; IEA:EnsemblProtists.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0051591; P:response to cAMP; IEA:EnsemblProtists.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF61; RAPA GUANOSINE TRIPHOSPHATASE-ACTIVATING PROTEIN 1; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064}.
FT DOMAIN 629..887
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 896 AA; 101206 MW; ED33EB20BC620FF9 CRC64;
MKSETSTENL ISDFSSNNKI TTEEEERRSE ELQKILLDII PILNRGVEQL GIEVEQICSG
DTAYEKKPIC QVLIDIQKTL REYPRGMGYR SKSIPPNLNG KPKLIQFRSN MDQLVWENIS
KLTILKDFVE FTVQLQKLCV IGMSIRDSLN SFLNNKCESF IKGYESSLNG LNIHTLGTGI
ILHHHSYSSG QQQQQVVPQQ DPSEYSDSEG NSVESSIISF NVTSMIHNNV KEEINNTSIS
ALKKSQKQQP AVLSRAPKQV MESTRILVDN VVNRKCMYRE EKASIYREMM NDRLNLLKED
PKKYKLQLLQ QRRQKLATSA ETEYDDSSNG ISIKKGGSEH GSVSLSPQNS GASGSPSSDK
ENSPLMTSPQ YLSTSPPKSP PKSPEFLGVA AKGKKSHLLG HARSFSADTH RELTPNSHQH
ISHNNLGVAS PPISPRLEKI LKSYKLVSAS PSSSSSAVVT SAVSHQLLSA AVANIENANN
SSTEFGEWEE VPEGKSEHIL QCKGYKMDIG NSKCNQIYSG HELSVLYTDE DEYHYLDDFS
ALEHFNFLGV NKNQPDNPMC VSAAVLHESN ELLCIIRTGD KDEKYRISLN GKKDLSGKDM
IKMIKKSRFN QMSNFKLKEV KDVSFSKHLL NFEAKNIHKT FKFGVLYCRE DQGHDENELY
SNNETSEAFQ EFLKVLGSRV TLQGWTKYRG GLDVKDNTTG THSVYKKWRD FEIMYHVAPM
IPCRAADEQS VERKRHLGND IVLIIFKEGK NNKFDPSIIK SNFNHIFAVI QVDDSRQSPN
TQHHNNVSDE NQNEINSSSN NEEINIQTSN NNLKSNNNHV FYKVSIGCKE EVSDFGPAFP
KSHIFKSNDN FTDFLLTKLI NGERSTLKSP VFAQKIKRTR KEFLHSFISD FQDKSI
//
