ID F162A_RAT Reviewed; 155 AA.
AC Q4QQV3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=Protein FAM162A;
DE AltName: Full=E2-induced gene 5 protein homolog;
GN Name=Fam162a; Synonyms=E2ig5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP RETRACTED PAPER.
RX PubMed=19520982; DOI=10.1161/strokeaha.109.553644;
RA Qu Y., Mao M., Zhao F., Zhang L., Mu D.;
RT "Proapoptotic role of human growth and transformation-dependent protein in
RT the developing rat brain after hypoxia-ischemia.";
RL Stroke 40:2843-2848(2009).
RN [3]
RP RETRACTION NOTICE OF PUBMED:19520982.
RX PubMed=32272861; DOI=10.1161/str.0000000000000232;
RA Qu Y., Mao M., Zhao F., Zhang L., Mu D.;
RL Stroke 51:e103-e103(2020).
CC -!- FUNCTION: Proposed to be involved in regulation of apoptosis; the exact
CC mechanism may differ between cell types/tissues. May be involved in
CC hypoxia-induced cell death of transformed cells implicating cytochrome
CC C release and caspase activation (such as CASP9) and inducing
CC mitochondrial permeability transition. May be involved in hypoxia-
CC induced cell death of neuronal cells probably by promoting release of
CC AIFM1 from mitochondria to cytoplasm and its translocation to the
CC nucleus; however, the involvement of caspases has been reported
CC conflictingly. {ECO:0000250|UniProtKB:Q9D6U8}.
CC -!- SUBUNIT: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A
CC mitochondrial localization and pro-apoptotic activity. Interacts with
CC VDAC2; the interaction is probably involved in inducing mitochondrial
CC permeability transition. {ECO:0000250|UniProtKB:Q96A26}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q96A26}; Single-pass membrane protein
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the UPF0389 family. {ECO:0000305}.
CC -!- CAUTION: A paper showing a role in apoptosis in neurons has been
CC retracted due to panel duplication in several figures.
CC {ECO:0000269|PubMed:19520982, ECO:0000305|PubMed:32272861}.
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DR EMBL; BC097971; AAH97971.1; -; mRNA.
DR RefSeq; XP_006248475.1; XM_006248413.3.
DR AlphaFoldDB; Q4QQV3; -.
DR SMR; Q4QQV3; -.
DR BioGRID; 262154; 1.
DR IntAct; Q4QQV3; 1.
DR STRING; 10116.ENSRNOP00000040367; -.
DR GlyGen; Q4QQV3; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q4QQV3; -.
DR PhosphoSitePlus; Q4QQV3; -.
DR jPOST; Q4QQV3; -.
DR PaxDb; 10116-ENSRNOP00000040367; -.
DR UCSC; RGD:1590883; rat.
DR AGR; RGD:1590883; -.
DR CTD; 26355; -.
DR RGD; 1590883; Fam162a.
DR VEuPathDB; HostDB:ENSRNOG00000002255; -.
DR eggNOG; ENOG502S1PN; Eukaryota.
DR HOGENOM; CLU_122911_0_0_1; -.
DR InParanoid; Q4QQV3; -.
DR OrthoDB; 2970852at2759; -.
DR PRO; PR:Q4QQV3; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000002255; Expressed in heart and 20 other cell types or tissues.
DR ExpressionAtlas; Q4QQV3; baseline and differential.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR GO; GO:0071456; P:cellular response to hypoxia; ISO:RGD.
DR GO; GO:0051402; P:neuron apoptotic process; ISO:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; ISS:UniProtKB.
DR InterPro; IPR009432; DUF1075.
DR PANTHER; PTHR13674; GROWTH AND TRANSFORMATION-DEPENDENT PROTEIN; 1.
DR PANTHER; PTHR13674:SF2; PROTEIN FAM162A; 1.
DR Pfam; PF06388; DUF1075; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..155
FT /note="Protein FAM162A"
FT /id="PRO_0000254638"
FT TRANSMEM 102..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 77..103
FT /note="Required for proapoptotic activity"
FT /evidence="ECO:0000250|UniProtKB:Q9D6U8"
SQ SEQUENCE 155 AA; 17827 MW; DFE409E2EA4687E0 CRC64;
MWSLRGLRLA AGHCFRLCER NVSSPLRLTR NTDLKRINGF CTKPQESPKA PTQSYRHRVP
LHKPTDFEKK ILLWSGRFKK EEEIPETISF EMLDAAKNKI RVKVSYLMIA LTVAGCVYMV
IEGKKAAKRH ESLTSLNLER KARLREEAAM KAKAD
//
