ID F1A178_DICPU Unreviewed; 499 AA.
AC F1A178;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Amine oxidase {ECO:0000256|RuleBase:RU362067};
DE EC=1.4.3.- {ECO:0000256|RuleBase:RU362067};
GN ORFNames=DICPUDRAFT_58486 {ECO:0000313|EMBL:EGC30059.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC30059.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a secondary aliphatic amine + H2O + O2 = a primary amine + an
CC aldehyde + H2O2; Xref=Rhea:RHEA:26414, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:17478,
CC ChEBI:CHEBI:58855, ChEBI:CHEBI:65296; EC=1.4.3.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000205};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362067};
CC -!- SIMILARITY: Belongs to the flavin monoamine oxidase family.
CC {ECO:0000256|ARBA:ARBA00005995, ECO:0000256|RuleBase:RU362067}.
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DR EMBL; GL871363; EGC30059.1; -; Genomic_DNA.
DR RefSeq; XP_003293422.1; XM_003293374.1.
DR AlphaFoldDB; F1A178; -.
DR STRING; 5786.F1A178; -.
DR EnsemblProtists; EGC30059; EGC30059; DICPUDRAFT_58486.
DR GeneID; 10511266; -.
DR KEGG; dpp:DICPUDRAFT_58486; -.
DR eggNOG; KOG0029; Eukaryota.
DR InParanoid; F1A178; -.
DR OMA; EWTRGAY; -.
DR OrthoDB; 5471885at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0097621; F:monoamine oxidase activity; IEA:RHEA.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.10.405.10; Guanine Nucleotide Dissociation Inhibitor, domain 1; 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001613; Flavin_amine_oxidase.
DR PANTHER; PTHR43563; AMINE OXIDASE; 1.
DR PANTHER; PTHR43563:SF20; AMINE OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR PRINTS; PR00757; AMINEOXDASEF.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|RuleBase:RU362067};
KW Flavoprotein {ECO:0000256|RuleBase:RU362067};
KW Membrane {ECO:0000256|RuleBase:RU362067};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU362067};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Transmembrane {ECO:0000256|RuleBase:RU362067};
KW Transmembrane helix {ECO:0000256|RuleBase:RU362067}.
FT TRANSMEM 476..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362067"
FT DOMAIN 16..452
FT /note="Amine oxidase"
FT /evidence="ECO:0000259|Pfam:PF01593"
SQ SEQUENCE 499 AA; 56735 MW; 55BD40F503D386D6 CRC64;
MEESIIHDVV VVGAGLSGLR TSSLLKDENI SVLLLEAQDR VGGRTDSVKI DNYNWDLGGQ
WVGPTQYRIN ELVKDCNQTT FPQQQKGKKV MEINGTHARY TSLIPPIGLG AVIECQLVVW
RLDYLSRDLD VTQPWNWKHA EHYDSISMRD WMEDHMYFET SKKLIYISIL AVFSAEPKDI
SVLFAMTYFK SAGGVSKTIE VEGGAQQDRI YGSSHNISNI LSKKLLIPSA IKIEHDYKTK
DIIRTTTRNI KTNEECVYLS KYLVLTVPPN IADTIVYQPE LPTIRRQLTK STKMGKVIKF
IIFYQDCWWR DLGFSGEVVS DRPSISFCYD GSFEDGSKSS IIGFFEGDYA IEWGKKSELE
RKNEAMAFIY QSFSDDRAFS PTNYLERNWA SNPWSNGGYG CIMGPHDYSN YGKALREPIG
NIHFAGTETA TEWAGYMEGA LQSAERVSNE IIPKFNSNYK PQLKTNLNGH SNNLNFLNYL
IMISSMVLIV ILIFYNLLI
//
