ID F1A2I8_DICPU Unreviewed; 3845 AA.
AC F1A2I8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EGC29598.1};
GN ORFNames=DICPUDRAFT_158801 {ECO:0000313|EMBL:EGC29598.1};
OS Dictyostelium purpureum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=5786 {ECO:0000313|EMBL:EGC29598.1, ECO:0000313|Proteomes:UP000001064};
RN [1] {ECO:0000313|Proteomes:UP000001064}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QSDP1 {ECO:0000313|Proteomes:UP000001064};
RX PubMed=21356102; DOI=10.1186/gb-2011-12-2-r20;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Sucgang R., Kuo A., Tian X., Salerno W., Parikh A., Feasley C.L., Dalin E.,
RA Tu H., Huang E., Barry K., Lindquist E., Shapiro H., Bruce D., Schmutz J.,
RA Salamov A., Fey P., Gaudet P., Anjard C., Babu M.M., Basu S.,
RA Bushmanova Y., van der Wel H., Katoh-Kurasawa M., Dinh C., Coutinho P.M.,
RA Saito T., Elias M., Schaap P., Kay R.R., Henrissat B., Eichinger L.,
RA Rivero F., Putnam N.H., West C.M., Loomis W.F., Chisholm R.L., Shaulsky G.,
RA Strassmann J.E., Queller D.C., Kuspa A., Grigoriev I.V.;
RT "Comparative genomics of the social amoebae Dictyostelium discoideum and
RT Dictyostelium purpureum.";
RL Genome Biol. 12:R20.1-R20.23(2011).
CC -!- FUNCTION: Mediates the transfer of lipids between membranes at
CC organelle contact sites. {ECO:0000256|ARBA:ARBA00033718}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; GL871413; EGC29598.1; -; Genomic_DNA.
DR RefSeq; XP_003293882.1; XM_003293834.1.
DR STRING; 5786.F1A2I8; -.
DR EnsemblProtists; EGC29598; EGC29598; DICPUDRAFT_158801.
DR GeneID; 10505197; -.
DR KEGG; dpp:DICPUDRAFT_158801; -.
DR eggNOG; KOG1809; Eukaryota.
DR InParanoid; F1A2I8; -.
DR OMA; GPTNILR; -.
DR OrthoDB; 23713at2759; -.
DR Proteomes; UP000001064; Unassembled WGS sequence.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:EnsemblProtists.
DR GO; GO:0016045; P:detection of bacterium; IEA:EnsemblProtists.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0051593; P:response to folic acid; IEA:EnsemblProtists.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR PANTHER; PTHR16166:SF97; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13F; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001064};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..114
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 313..550
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 901..1018
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1085..1180
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 3477..3637
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3645..3728
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT REGION 136..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 856..890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1094
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1454..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2663..2699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3059..3103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3251..3271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2206..2240
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 146..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..286
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3059..3088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3089..3103
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3845 AA; 442671 MW; 39CFD98353973BBC CRC64;
MFETLVSNLL QRYLGEYIQS LNTENLNISI LKGNVSLENL QLKKRALEKF NLPFTIKEGF
LGKLSLKIPW NNLKTEPVIV IIDNLYITAS PKSATSWDKE DEELLFQKKI KKLKIYEALK
EEKRKKILEQ KEKREKRKKL LKEKRQQKQQ QKFEKKKQQQ RQLIKNRNLK NNDDNNNNNN
NNNNNNNNDI NIFKDDNQNN EDNSINENNT VNDKDNNENN DSHSSPTTLE DGSTYSINRE
ESEGGSNTDE TNLDEEEDDE DYDDDDDEDY EEYDEEEEEE EEEYDEQLIQ DEIYKGVLKD
SFDENENQSS SSFADKLRNK IVDNLQIMIY NVHVRFEDSI TNPLSPYCFG ITLEHLLAQS
SNEEWKPTFI HISQSLVHKL INLQNLSVYW DPHSSDPNLN YKNISDFKTI MTQLIPKKSI
DQSKNPNHNY LLHPVCGSLK LLINKSLIPN KFIPLYTANF EFDEINLEIE SRQYSGILAL
VEWFSMLKRG EKYRKFKPKE CGGILKTAKD RWSFALECIR NEVREKLLKW SPKYFEKRRK
DRLDYIHLYK LKKRKKNITD SNNIRIDQLE RDYSFEDLVY FRSLADAQIK AEDSVRSNPN
TPLLLSPKST SVYNNQLENK NDDNNSNNNI NNNNNNNNDN NNNSETTKKI EIIDSSSNSN
NKINPSSKNV NIGNNSNGNN SNGGWFRWLW GGSKKNEEGT TDQESILSTL DLTEQQKREL
YSTIEYDEHQ VSKNIVYPKD YVKTRINFTM NRGSVAFRLK PPTSPITHFP DSSKSKPKSA
DLVIELVNMS ISLDKFVESL YVQTILETIF VRDYFTDNTQ FPILMKPILN SYSNNINNNN
NKNYLSINSS PILKNNKIKN NSGNNNSDNS CYKDNNENNE SGELSSDEEA TKQPLFSMTL
QQNPLTSESD FSVFIEALPL EIIYNKSMMD SILEFFGNAP SDTLKDIEEA ARNQIKIFKD
KTTLRIQYEL QNHKSVDLDI NINAPHVLIP ENFTNPSSPI LVLDLGSFSL QRVITHKTSD
TMPEEIEASS ILRNDLSLYN SNINNENNID YNDNNNNNNN NNNNNNNNYQ ESSASSPSFS
QSQPIKNSHG SSDGNVYDDE NVTKYLYDLF ELKLGNIQFY LVSGGELIQL VEKFDINFKI
FKCIIKSQTL LSKLKLFGDL PSLNILLSQK SIEIMIRIIG TLQNDPPEIS NHLISSENLM
DNQQINDQNN INKNEENEDL IIDIDNRSNS TSSVSNTATL LEGTDENSNI INSSTLIDSM
ELENPQDQLP ILMIFHTIFE VTFSIPTVSL EVREDLHNKP FVKLILSDIS AQVLKRTFDT
TVHLSLKKLY IEDLYQDFKN ENFRYLAKSL NEYIPHQDQD LSCSEIAEEE HLINISILSV
QRNSPQYIGV SQKIDVFFNT LFVNLNKKLV IKIINMIELV EKTIIDTVIQ RREKRNLKKQ
QHDHENDIII EHQQEQEQEQ QQHNEEQEFK KENIEQKEQN NQQSKQKFKT NSKRKKKEED
NPMVNITIKM KSLIVNLNED DQSYFMFQVS DLSIYFDIDL ESSMMRFKLG NLEISDISKD
ASKDLNPLFG TDGEHIIEFY VLTYKNIKLP QFKENNEEKE NDNEEKESDN EEKGKEEEEN
DFQYDKNGEV INFNSKISVR MTSVKLIVIV SLIEKIIDYF DEIITSQIDH IITESAKGAV
EIMSNRRIAQ QKRILFEIDV DTPRIIFPKN HISPYVIIAD LGHISIFNQY NINALSPSEQ
IFIYASSINF HSCKFLNGKV LDSTIEAISN KINIHVNIES FIKVSEQSES KQKVDGEISP
IHLKISDQQY TLIIAIIKSL IEPNIKQKKR KKRNHRRMES QIKLDNLYQS FINVAQSNQT
HGIDMNHSNL ISSLPIPTPL PVNTPLSAPL SNNGSTTDIK DQISFHLPHV SLEFFRKNKE
SVVSLEVIEF ACSIIEYENG NEYSNFSVGS IDLTDTRKSI VNHFRKLIHH QNSPNKNDNS
GTKKELQVYV CDKRNGDTEV KVLLDSFRGI IVPESLVSMI DFIMPGIKAL SSLSEISPIS
SPVLDSDAIN NNPLFNQDPT KSIPVKNILE QKNKRSMGQT TLVHIETTNV ELSLVDNPAS
HESRLLTLKG SVLGKINIQV CEPLTYKDFQ ISVENLELYK CRANNFEQTA ESIIDPFTIT
ASISLVEGKE YLPIDILIGV NPIHLSISYQ DFLLFLSISN HLNILINNLN RLLNNQQINN
KNNQQQNNNN NNNNNKEKKE ILRINFQSPS IELTIINDDD NKYFGVLNFK FNNISVEVSQ
NRIMVGLFLS SNYFNISKSV WEPVIEEWGC KLAIETSNTP VSEIGNIVLT TNQNLNLNIT
KSLFDTIISS YPVFISALTN SNQENLDSTV ILGYNNNLSQ HYKSQNYHPF LLKNHTGLEI
QYSVIKLSNE LYKNKNNNNN NNNNNNEKNN FKVLNNLILE NGNEVYLDLR DISLSSKNEK
DRFKTINNTQ KHRDTTSISL FRVNITVKGF ETITNLPIHK TGIYICNLIP KQNHNNHSNT
NISSTTSNYE LITPEKQYQQ LVFEIKVSKS SKILIVRSNV LIVNDTDHAI EFLDRPSHTF
KSSPYILEPN QSKPMSLCKD QSSPSMILSF RPLLDSHQNH QQRWTSPLDC SDSFLHPGTL
LFDCPPNKFY FLKIDQHLSN YQFEEPTNSS QQQQQQQQQQ QQQQQQQQQQ QQNQHQQYHH
INKRQYYEYK VENSFEERRS NHIIKIVAPL VIINYFIVPI DVSFYDQESN NIVGKEKIES
GKRKDIYCAN IEKVIMIKVH MEGYGWSEYI QINQSSPNNI NRQPRKILST SNGKPFYLNV
HQNEFFGSIQ VSLYSSFSII NNTGLSIQYK LNNINVVGNN KLSTTTTSTT TTKTSFSKTP
IISDNNEKNE KNLETISIYT DPRNWYSNNN VVCSMFSPIS AHSITTQQLL LQVDNSNWSS
PISIQLNKFE PITIVKEHRH SEKLFLQFLL YTQIESGSLT KTITISPQFI LINNISNNLY
YSQKDSSLYK KFFIKPKETL PFHFLEEQLP KKITFRLSEK IEWSGSFNIN KTISFNIQLE
KPQDDNDQSS SSSDSDSDLS SSSSNSNSSD NEDDDDDDDI TADNDEDFYL PMIQILQEKG
IYYVIINPET KDYPPYIIQN LISLPISIHQ VDTNDQPIFV YSNHSKRYTW SNPMGTKRLS
ITIPNTNYKK IVSLDKLQYH QPFPVKYQSS SSKIKDLNIK LEILANGPTN ILRMIDLNDI
KSINRKEKLT NNNQTQQQEQ QEQQEQQQEE KEQKIIYNNQ TQKQQQQQQE QKNLSNKIKL
NNFEFYIGGI SVSVIDSIPK ELLFITLKGL QVRFKEINTE QNINISIHSF KVDNQLYHTP
YPVMISSFNS NTTSPTSHSL IVNFIRSSQY QPKELHQIGI EYIKELRFDI QPFEVQIDEA
LLFHLVSFIN NVKCSFNNSS IPLTKQEKKD DQNLIIDKIK LPYSNIPLPI TINSKRLYIE
FLYLPQVDIK LSYRSSPHNR PMIGPWASSA FSALANIDNA SLHLESWKLE HQFVTANGLG
LSLFYHYKWK VSKILLYSGF LGAPLSLAEN ITRGINDLIN ESSAGFTNPE DFTKGVYKGT
KSLVSNSLFG IFNSASKFTN TIGTAIAPFS MDENYLQQRD NSYRHSQQPK HVLDGVSNGI
EKFSEGIAHG LSGLVNQPVK EFQDQGFTGL VKGLGKGLLG TFVKPTVGAI DMINSASQGL
RNVYSDPSAC KSRSRPPRFI GSDGVIKSFS FEKSFWQELI KVSIKPSLLS SKEFYITHFK
VYDDKKVPSY LVISTINFYL FNSKFNLSLM IKLWDSNGKS ISYSLLNSIQ NTISSIKMDQ
TYFIS
//
