ID F1CT58_9ACTN Unreviewed; 370 AA.
AC F1CT58;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Acyl-CoA dehydrogenase {ECO:0000313|EMBL:AQA10457.1};
DE SubName: Full=GdmI {ECO:0000313|EMBL:ADY75587.1};
GN Name=gdmI {ECO:0000313|EMBL:ADY75587.1};
GN ORFNames=BV401_08125 {ECO:0000313|EMBL:AQA10457.1};
OS Streptomyces autolyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=75293 {ECO:0000313|EMBL:ADY75587.1};
RN [1] {ECO:0000313|EMBL:ADY75587.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JX-47 {ECO:0000313|EMBL:ADY75587.1};
RX PubMed=21544574; DOI=10.1007/s00284-011-9940-2;
RA Dai S., Ouyang Y., Wang G., Li X.;
RT "Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial
RT Chromosome Library Construction and Identification of Clones Covering
RT Geldanamycin Biosynthesis Gene Cluster.";
RL Curr. Microbiol. 63:68-74(2011).
RN [2] {ECO:0000313|EMBL:ADY00175.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 0516 {ECO:0000313|EMBL:ADY00175.1};
RX PubMed=21682254; DOI=10.1021/ol201383w;
RA Yin M., Lu T., Zhao L.X., Chen Y., Huang S.X., Lohman J.R., Xu L.H.,
RA Jiang C.L., Shen B.;
RT "The missing C-17 O-methyltransferase in geldanamycin biosynthesis.";
RL Org. Lett. 13:3726-3729(2011).
RN [3] {ECO:0000313|EMBL:AQA10457.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC0516 {ECO:0000313|EMBL:AQA10457.1};
RX PubMed=28472671; DOI=10.1016/j.jbiotec.2017.04.037;
RA Yin M., Jiang M., Ren Z., Dong Y., Lu T.;
RT "The complete genome sequence of Streptomyces autolyticus CGMCC 0516, the
RT producer of geldanamycin, autolytimycin, reblastatin and elaiophylin.";
RL J. Biotechnol. 252:27-31(2017).
RN [4] {ECO:0000313|Proteomes:UP000187851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC0516 {ECO:0000313|Proteomes:UP000187851};
RA Yin M., Jiang M., Lu T.;
RT "Streptomyces autolyticus CGMCC0516 complete genome sequence.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|RuleBase:RU362125};
CC -!- SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009347, ECO:0000256|RuleBase:RU362125}.
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DR EMBL; HQ840740; ADY00175.1; -; Genomic_DNA.
DR EMBL; HQ538722; ADY75587.1; -; Genomic_DNA.
DR EMBL; CP019458; AQA10457.1; -; Genomic_DNA.
DR AlphaFoldDB; F1CT58; -.
DR STRING; 75293.BV401_08125; -.
DR KEGG; sauo:BV401_08125; -.
DR OrthoDB; 9802447at2; -.
DR Proteomes; UP000187851; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR CDD; cd00567; ACAD; 1.
DR Gene3D; 1.10.540.10; Acyl-CoA dehydrogenase/oxidase, N-terminal domain; 1.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 1.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR013786; AcylCoA_DH/ox_N.
DR InterPro; IPR037069; AcylCoA_DH/ox_N_sf.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR PANTHER; PTHR43884; ACYL-COA DEHYDROGENASE; 1.
DR PANTHER; PTHR43884:SF42; SHORT-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR Pfam; PF02771; Acyl-CoA_dh_N; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU362125};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|RuleBase:RU362125};
KW Oxidoreductase {ECO:0000256|RuleBase:RU362125}.
FT DOMAIN 16..109
FT /note="Acyl-CoA dehydrogenase/oxidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02771"
FT DOMAIN 112..202
FT /note="Acyl-CoA oxidase/dehydrogenase middle"
FT /evidence="ECO:0000259|Pfam:PF02770"
FT DOMAIN 222..364
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
SQ SEQUENCE 370 AA; 38521 MW; 61B748C77D13BF8C CRC64;
MTDAATDHAE LVSGLIGDRA DAWDLAGELP RDLLVKLGAS GVLCAQVGPE HGGTGLDSRA
GGELTARVGA RCSSLRSVMT SQGMAAWTVR RLGGTEQWDT FLPRLTSGDL AAVGFSEPGA
GSDLSAMETE IADDGAEVVV TGRKVWITAA HYADLLLVFG KYRGGATAVV VPARTPGVRI
TRVENPLGCR AAGHANITLD AVRVPAGHVL GGTGLPLSLA TTAALTYGRM SVAWGCVGIL
RACLDAAATH TATREQSGRA LAEHQLVARH LAELYVAERH ATRACEHASA SWDTGSPDMA
VDAVHAKYVA SREAAQGAAR AVQLLASAGA SDGHVVARAY RDAKLMEVIE GTSEICQLVL
ARHMRKKVRP
//
