ID F1CT63_9ACTN Unreviewed; 354 AA.
AC F1CT63;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=3-dehydroquinate synthase {ECO:0000313|EMBL:AQA10461.1};
DE SubName: Full=GdmO {ECO:0000313|EMBL:ADY75592.1};
GN Name=gdmO {ECO:0000313|EMBL:ADY75592.1};
GN ORFNames=BV401_08150 {ECO:0000313|EMBL:AQA10461.1};
OS Streptomyces autolyticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=75293 {ECO:0000313|EMBL:ADY75592.1};
RN [1] {ECO:0000313|EMBL:ADY75592.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JX-47 {ECO:0000313|EMBL:ADY75592.1};
RX PubMed=21544574; DOI=10.1007/s00284-011-9940-2;
RA Dai S., Ouyang Y., Wang G., Li X.;
RT "Streptomyces autolyticus JX-47 Large-Insert Bacterial Artificial
RT Chromosome Library Construction and Identification of Clones Covering
RT Geldanamycin Biosynthesis Gene Cluster.";
RL Curr. Microbiol. 63:68-74(2011).
RN [2] {ECO:0000313|EMBL:ADY00180.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC 0516 {ECO:0000313|EMBL:ADY00180.1};
RX PubMed=21682254; DOI=10.1021/ol201383w;
RA Yin M., Lu T., Zhao L.X., Chen Y., Huang S.X., Lohman J.R., Xu L.H.,
RA Jiang C.L., Shen B.;
RT "The missing C-17 O-methyltransferase in geldanamycin biosynthesis.";
RL Org. Lett. 13:3726-3729(2011).
RN [3] {ECO:0000313|EMBL:AQA10461.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CGMCC0516 {ECO:0000313|EMBL:AQA10461.1};
RX PubMed=28472671; DOI=10.1016/j.jbiotec.2017.04.037;
RA Yin M., Jiang M., Ren Z., Dong Y., Lu T.;
RT "The complete genome sequence of Streptomyces autolyticus CGMCC 0516, the
RT producer of geldanamycin, autolytimycin, reblastatin and elaiophylin.";
RL J. Biotechnol. 252:27-31(2017).
RN [4] {ECO:0000313|Proteomes:UP000187851}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGMCC0516 {ECO:0000313|Proteomes:UP000187851};
RA Yin M., Jiang M., Lu T.;
RT "Streptomyces autolyticus CGMCC0516 complete genome sequence.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; HQ840740; ADY00180.1; -; Genomic_DNA.
DR EMBL; HQ538722; ADY75592.1; -; Genomic_DNA.
DR EMBL; CP019458; AQA10461.1; -; Genomic_DNA.
DR AlphaFoldDB; F1CT63; -.
DR STRING; 75293.BV401_08150; -.
DR KEGG; sauo:BV401_08150; -.
DR OrthoDB; 9806583at2; -.
DR Proteomes; UP000187851; Chromosome.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd08195; DHQS; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR030960; DHQS/DOIS.
DR PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR PANTHER; PTHR43622:SF7; 3-DEHYDROQUINATE SYNTHASE, CHLOROPLASTIC; 1.
DR Pfam; PF01761; DHQ_synthase; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 74..316
FT /note="3-dehydroquinate synthase"
FT /evidence="ECO:0000259|Pfam:PF01761"
SQ SEQUENCE 354 AA; 36897 MW; 8E6CEED178BE539B CRC64;
MTTSTSSPAA SSAAPFRQVT VALAERSYTV HIGHGVRRLL PRVVSALGAR KAVVVTARPP
EQTPDPKVPS LVVSTRDGEE AKDLAAVTDL CRRFVEFGLT RSDVVVSCGG GTTTDTVGLA
AALYHRGTPV VHVPTSLLAQ VDASVGGKTA VNLPEGKNLV GAYWQPAAVL CDLDHLTTLP
EREWRNGLGE IARCHFIGAP DLDGLPLLDQ IAASVTLKAG IVAADERDAG LRHILNYGHT
LGHALERATG FALRHGEGVA IGTVFAGRLA GALGRIGPER VAEHHDVVAR YGLPTALPAQ
VPVAELVELM RLDKKATDGL TFVLDGPDGP GLVPGIPEDT VSATLAAMPR EPAG
//