ID F1LPD3_RAT Unreviewed; 3079 AA.
AC F1LPD3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Centrosomal protein 350 {ECO:0000313|Ensembl:ENSRNOP00000005235.8};
GN Name=Cep350 {ECO:0000313|Ensembl:ENSRNOP00000005235.8,
GN ECO:0000313|RGD:621162};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000005235.8, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000005235.8, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005235.8,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000005235.8}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000005235.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 10116.ENSRNOP00000005235; -.
DR iPTMnet; F1LPD3; -.
DR PhosphoSitePlus; F1LPD3; -.
DR PaxDb; 10116-ENSRNOP00000005235; -.
DR PeptideAtlas; F1LPD3; -.
DR Ensembl; ENSRNOT00000005235.9; ENSRNOP00000005235.8; ENSRNOG00000003882.10.
DR AGR; RGD:621162; -.
DR RGD; 621162; Cep350.
DR VEuPathDB; HostDB:ENSRNOG00000003882; -.
DR eggNOG; KOG4568; Eukaryota.
DR GeneTree; ENSGT00940000155130; -.
DR HOGENOM; CLU_000421_0_0_1; -.
DR InParanoid; F1LPD3; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000003882; Expressed in testis and 18 other cell types or tissues.
DR ExpressionAtlas; F1LPD3; baseline and differential.
DR GO; GO:0005814; C:centriole; ISO:RGD.
DR GO; GO:0005813; C:centrosome; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0034453; P:microtubule anchoring; IEA:InterPro.
DR GO; GO:1905515; P:non-motile cilium assembly; ISO:RGD.
DR GO; GO:0071539; P:protein localization to centrosome; ISO:RGD.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR028750; CEP350/CC187.
DR InterPro; IPR025486; DUF4378.
DR PANTHER; PTHR13958; CENTROSOME-ASSOCIATED PROTEIN 350; 1.
DR PANTHER; PTHR13958:SF4; CENTROSOME-ASSOCIATED PROTEIN 350; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF14309; DUF4378; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 2499..2541
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..995
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1150..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1570..1658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1718..1737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1786..1860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1890..2074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2113..2141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2190..2419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2432..2462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2685..2712
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 466..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1489..1504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1545
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1601..1648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1786..1806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1817..1837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1838..1860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1890..1908
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1922..1936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1946..1961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1981..1996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2014..2036
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2037..2074
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2191..2220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2276..2296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2302..2318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2339..2359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2371..2402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2434..2458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3079 AA; 344782 MW; 88DE6146FDF22A6E CRC64;
MRSSKSKEVP LPNPRNSQSK ETVQDVTTSW DALSQTKAAL RHIENKLEVA PTSTAVIDSV
MDAKKSASAT RKISRKDGRC LDDSWVSAPT SKFSKPRKEK SRSPLRATTL ESNVKKNNRV
EFREPLVSYR ETHGTLFSLS PSHLESKHVY CIHEEKPENG KQMVVSREDR NSHCCDFESA
QPSVISDTVV RFLNDGPAID ALHSSECLMK MGVHIRTEEE MPNRTKGSEN NSKPSLNSME
HDVDPNVLLL SDSSPSSTSA CNSQRVGICK RQQHDVKLEK LKERIRKQWE HSEEINGHAQ
TLGHIDHPVM VVNVDNSVTT KVRKVATAPP APAYKGFNPS ETKIRTPDGK VWQEAEFQSM
SRELYHDLAL QFADDTSVKE KPVEKSKEKK VVKPVRKIQK VTQLSNPECK TGGSRLISTS
SWRDGQKLVK RILGPAPTME QRARRPASSD GRGRGRGATG GHIGRAESDP KLDVSHKQLP
RSSERSRSRA WSENNVVKSA LSLPDNKQEE NAALNKDFLP VEIRGILDDL QLDSSAQTVR
QEVGEVQNQK SVASVQAPRS HSPVKRKPDK ITANEDPPVI SKKRHYDTDE VRQYIVRQQE
ERRRRQHEEK KAQKEATEQK NKRLQELYRK QKEAFTKAKP VPPSDPSTSR RLQETYSKLL
LEKTLLEEPA RQHATPETQT RPGYQPSGES DKENKVQERP PSASSSSDLS LSEPPQPLAR
RDLMEPTWMQ PDRLSPRVHS SQAQPLVGTT ENLLSHLLHL EHVGILHKDY ESVLPAKKSH
NKASGPLTFT PQPYLTSQAP HPDALLKPST SQYKSKLDRI EALKATAASL SSRIESEAKK
LAGASINYGS VWNTECDGKL AAQDNGPWTK AISSPVKEGV EDAFSARIQK MLGTCIAHAT
FDDELPGVGS LSEYKKLPEM IRPLSAVSSL RVKSPSPNPG GLLAQLCRKQ ADSSSSDIQA
CSKERAKRSL CSSIDSVSEG PLLSEGSLSE EEGRRDARPL LKVAEILKEK EFCAGERNPY
EPIKEFQKEA EKFLPLFGHI GGTQSKGPWE ELAKGSPHSV INIFTKSYQL YGKGFEDRGT
SASRPLNATT TPLSSVSYED DFVSSPGSGT LTEKKSALES QIDGSNLGIQ EDHSSRKFAY
DLSSLDVTSQ HSSGAHSAVS TRSSASKGKK GKKEKMDWLD SFTENAQNIL NDEEKVQSDS
ERGSPQGRKL GTSSKLAVRG YEQTLDAEST LEELSGHSVS GSSDKGRSQK TPTSPLSPSS
QKLLQFDLPG TSLERSKSSV IVPPTTAGFK PTAAFTDVNK TEMTSTPGPK RFSPAGLQHR
MAAELSYLSA IEESVRQLSD VERVRGISLA QQESVSLAQI IKVLRQEYLC EFKTSKVYVA
SSRTAETTTY RETLISFQVH AESLQQVVKS QREVTEVLQD ATCKIAAQQS ETARLTTDAA
RQICEMAELT RTHLADAITT SGVPLATLYD HQRQHFPDFM KQLRTKAETD RISQSASLSQ
SKEGTLDSKR QKYSPSRDSY SESSRYRSQD YQSSSGSSRQ ESPSVPPSKE NEKKFHGEKM
ETSIDEQLQT AADDSLRSDS IPSLPDEKDS TSIATEYSLK FDESMTEDEI EEKSFRSLLP
SESHRRFNME KKRGHHDDSD EDASPDKTTL CSTKELSMPF SGGQDSFSKF TMEMVRQYMK
EEEVRAAHQC SLLRLREKAL KEKTKAELAW LEHQKKHLRD KGEDDKMPPL RKKQRGLLLR
LQQEKAEIKR LQEANKAARK ERQLILKQQE EIERIRQTTI KLQEKLKSAG ENKLGPHGDD
DAEDKAASPG PPGSETRSPS PISISSSETS SIMQKLKNMR SRMDEKFLTK REQKLMQRRQ
HAEELLEWKR RLDAEEAEIQ QMEKQALAAW DKELAKPKTP KKELESQRTA QRGIASEEGS
LVPSYSLRNS ESCIPEELGS PSDLCMPSES RAQTQPGSPD HSLLTEEMIF PQELEPDSPS
KHSPPKSSLS LSKQESSKAS HRTEGHGHLP ARSRQPSYSW SDESLSMTQS ETTSDQSDIE
GRIRALKGEL RKRKSVVEQL KKEQRKRQKE RLKAQEASLL RQLETYDEFI KKTEGELSQD
LDTSPTSKFQ IKTLSSISEK PKIKPHPLHR SETAKTWKSV TESERYRGSL ASIAEHVDSS
LSYSERATSE RSLSAYAKRG VELDSRIEHL QASSPVLSSR KTQTESRDSL ESTPSLSPVK
ELNAPDQIYD VSESKAEDST QKSEIEEIES IKLERSEGED ASCKQSGGSE VLLKLDLTSG
TLSSKERPSD SANVHQDLVT PAMEVFHEKE EDSQSNPSRD DSSQDILSAG GVPGQECREN
GDSTLSGQLS VPKESSYSED FEVSSFKKGI SADEISKDDS EVSSPSLRKD AQSHRDKSWL
TRSSRSRTTG SGSDEEISEC LGEKSLSVHS GVHSERLLEL RSPTELMRSK ERSDVGHEQG
GTEPLPLAAV SAMEELPDFH IGDRVLIGNV QPGTLRFKGE TAFAKGFWAG VELDKPEGNN
NGTYDGIVYF VCKEKHGIFA PPQKISHILE NFDDYIDINE DEECYSDEQY QEQKDIECLK
DRENNIAEYF CEKSLPSIHN TEASVDEGRS LNIETDTPEV LEVRVHQQSS VDPPTSCKEN
KALVPAASES VCASMLSEEL QQQQLAEQEE NFSYQVSEKP STPLLDLLTR EKNQLEAQLK
SSISEEKKSK QQLETVSLLT DSLLQVFVKD TVSQLQQVKK ARNEKIQLSN QECLDQKKVL
PQDSPQNIEE QSLSVPSCFL RAELEDEKEE ISSPDMCPRP ESPVFGASGQ EELAKRLAEL
EISREFLNTL DDQDWFDEDF GLSSSHKIQK NKAEETIVPL MAEPKRVPQK PCETLSVVPH
TAEEVESLVH NAAEELWKWK ELGQDLHGFS IPAKFLGCAS KGLDIGNTSR RVYKQAVFDL
TKEIFEEIFA EDPNLNQPVW MKPCRINSSY FRRVKNPNNL DEIKHFITTE VLKLFSLKKE
PNHKTDWQKM MKFGRKKRDR VDHILVQELH EEEAQWVNYD EDELCVKMQL ADGIFEALIK
DTIDVLNQIS EKQGRMLLV
//
