ID F1LR67_RAT Unreviewed; 2170 AA.
AC F1LR67;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 2.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=ATP binding cassette subfamily A member 7 {ECO:0000313|Ensembl:ENSRNOP00000063805.2};
GN Name=Abca7 {ECO:0000313|Ensembl:ENSRNOP00000063805.2,
GN ECO:0000313|RGD:1303134};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000063805.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000063805.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000063805.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000063805.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000063805.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_006240933.1; XM_006240871.3.
DR RefSeq; XP_006240934.1; XM_006240872.3.
DR RefSeq; XP_006240935.1; XM_006240873.3.
DR RefSeq; XP_006240936.1; XM_006240874.3.
DR SMR; F1LR67; -.
DR Ensembl; ENSRNOT00000064886.5; ENSRNOP00000063805.2; ENSRNOG00000012939.8.
DR GeneID; 299609; -.
DR CTD; 10347; -.
DR RGD; 1303134; Abca7.
DR GeneTree; ENSGT00940000161439; -.
DR HOGENOM; CLU_000604_19_0_1; -.
DR OMA; AQEPLHS; -.
DR OrthoDB; 6951at2759; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000012939; Expressed in pancreas and 19 other cell types or tissues.
DR GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0034188; F:apolipoprotein A-I receptor activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0090554; F:phosphatidylcholine floppase activity; IEA:Ensembl.
DR GO; GO:0090556; F:phosphatidylserine floppase activity; IEA:Ensembl.
DR GO; GO:0034205; P:amyloid-beta formation; IEA:Ensembl.
DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR GO; GO:0034380; P:high-density lipoprotein particle assembly; IEA:Ensembl.
DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR GO; GO:0045332; P:phospholipid translocation; IEA:Ensembl.
DR GO; GO:1902991; P:regulation of amyloid precursor protein catabolic process; IEA:Ensembl.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF49; PHOSPHOLIPID-TRANSPORTING ATPASE ABCA7; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 588..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1253..1274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1561..1583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1603..1629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1641..1660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1672..1696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1759..1776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 805..1036
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1818..2050
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1044..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2129..2170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1064
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2170 AA; 237719 MW; 9E9F28A7A17B7F54 CRC64;
MAFCTQLMLL LWKNYTYRRR QPIQLVVELL WPLFLFFILV AVRHSHPPLE HHECHFPNKP
LPSAGTVPWL QGLVCNVNNS CFQHPTPGEK PGVLSNFKDS LISRLLADAH TVLGGHSTQD
MLAALGKLIP VLRAVGSGAW PQESNQPAKQ GSVTELLEKI LQRASLETVL GQAQDSMRKF
SDATRTVAQE LLTLPSLVEL RALLRRPRGS AGSLELISEA LCSTKGPSSP GGLSLNWYEA
NQINEFMGPE LAPTLPDSSL SPACSEFVGA LDDHPVSRLL WRRLKPLILG KILFAPDTNF
TRKLMAQVNQ TFEELALLRD LHELWGVLGP QIFNFMNDST NVAMLQKLLD VEGTGWQQQT
PKGQKQLEAI RDFLDPSRGR YNWQEAHADM GRLAEILGQI LECVSLDKLE AVPSEEALVS
RALELLGERR LWAGIVFLSP EHPLDSSEPP SPTTTGPGHL RVKIRMDIDD VTRTNKIRDK
FWDPGPSADP LMDLRYVWGG FVYLQDLLEQ AAVRVLSGRD SRAGLYLQQM PHPCYVDDVF
LRVLSRSLPL FLTLAWIYSV ALTVKAVVRE KETRLRETMR AMGLSRAVLW LGWFLSCLGP
FLVSAALLVL VLKLGNILPY SHPVVVFLFL AAFAVATVAQ SFLLSAFFSR ANLAAACGGL
AYFALYLPYV LCVAWRERLP LGGLLAVSLL SPVAFGFGCE SLALLEEQGD GAQWHNLGTG
PAEDVFSLAQ VSAFLLLDAV IYGLALWYLE AVCPGQYGIP EPWNFPFRRS YWCGPGPPKS
SVLAPAPQDP KVLVEEPPPG LVPGVSIRGL KKHFRGSPQP ALRGLNLDFY EGHITAFLGH
NGAGKTTTLS ILSGLFPPSS GSASILGHDV QTNMAAIRPH LGICPQYNVL FDMLTVEEHV
WFYGRLKGVS AAAIDSEQEH LIRDVGLIPK RDTQTRHLSG GMQRKLSVAI AFVGGSRVVI
MDEPTAGVDP ASRRGIWELL LKYREGRTLI LSTHHLDEAE LLGDRVAMVA SGSLCCCGSP
LFLRRHLGCG YYLTLVKSSQ SLVTHDLKGD TEDPRREKKS GSEGKTADTV LTRDGPHRSS
QAPAPDAVPV TPSAALILEL VQRHVPGAQL VEELPHELVL ALPYAGALDG SFATVFQELD
QQLERLGLTG YGISDTNLEE IFLKVVEEAH AHGEGGDPRQ QQHLLTATPQ PHTGPEASVL
ENGELAKLVL DPQAPKGSAP TTAQVQGWTL TCQQLRALLH KRFLLARRSR RGLFAQIVLP
ALFVGLALFF TLIVPPFGQY PPLQLSPAMY GPQVSFFSED APADPNRMKL LEALLGEAGL
QDPSVQGKGS RGSECTHSLA CYFTVPEVPP DVASILASGN WTPDSPSPAC QCSQPGARRL
LPDCPAGAGG PPPPQAMAGF GEVVQNLTGR NVSDFLVKTY PSLVRRGLKT KKWVDEVRYG
GFSLGGRDPD LPSGREVVRT VAEMRALLSP QPGNTLDRIL NNLTQWALGL DARNSLKIWF
NNKGWHAMVA FVNRANNGLL RAFLPSGSVR HAHSITTLNH PLNLTKEQLS EATLIASSVD
VLVSICVVFA MSFVPASFTL VLIEERITRA KHLQLVSGLP QTLYWLGNFL WDMCNYLVAV
CIVVLIFLAF QQKAYVAPEN LPALLLLLLL YGWSITPLMY PASFFFSVPS TAYVVLTCIN
LFIGINSSMA TFVLELLSDQ NLQEVSRILK QVFLIFPHFC LGRGLIDMVR NQAMADAFER
LGDKQFQSPL RWDIIGKNLL AMVAQGPLFL LITLLLQHRN RLLPQPKSRL PPPLGEEDED
VVRERERVTK GATQGDVLVL RDLTKVYRGQ RSPAVDHLCL GIPPGECFGL LGVNGAGKTS
TFRMVTGDTL PSSGEAVLAG HNVAQEPSAA HRSMGYCPQS DAIFDLLTGR EHLELFARLR
GVPEAQVAQT ALSGLVRLGL PSYADRPAGT YSGGNKRKLA TALALVGDPA VVFLDEPTTG
MDPSARRFLW NNLLSVVREG RSVVLTSHSM EECEALCTRL AIMVNGRFRC LGSAQHLKSR
FGAGHTLTLR VPPDQPEPAI AFIVTTFPDA ELREVHGSRL RFQLPPGGGC KLARVFRELA
AQGKAHGVED FSVSQTTLEE VFLYFSKDQG EEEEGSGQET ETREVSTPGL QHPKRVSRFL
EDPSSVETVI
//