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Database: UniProt
Entry: F1LS19_RAT
LinkDB: F1LS19_RAT
Original site: F1LS19_RAT 
ID   F1LS19_RAT              Unreviewed;      1768 AA.
AC   F1LS19;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   23-MAY-2018, entry version 60.
DE   SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|Ensembl:ENSRNOP00000054214};
GN   Name=Nalcn {ECO:0000313|Ensembl:ENSRNOP00000054214,
GN   ECO:0000313|RGD:628710};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000054214, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000054214, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000054214,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000054214}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000054214};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; AABR07019583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019590; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07019591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F1LS19; -.
DR   Ensembl; ENSRNOT00000057404; ENSRNOP00000054214; ENSRNOG00000004752.
DR   RGD; 628710; Nalcn.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; CQRIVGP; -.
DR   OrthoDB; EOG091G00F9; -.
DR   TreeFam; TF312843; -.
DR   Reactome; R-RNO-2672351; Stimuli-sensing channels.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000004752; -.
DR   ExpressionAtlas; F1LS19; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 3.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     41     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     67     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    299    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    881    905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    956    974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1017   1040       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1134   1157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1216   1243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1249   1267       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1274   1292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1334   1356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1421   1445       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      384    603       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      887   1162       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1209   1455       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      798    827       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1768 AA;  203782 MW;  A324D85C755AA9D8 CRC64;
     MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT
     FEHYPPLQYV TFTLDTLLMF LYTAEMIAKM HIRGIVKGDS SYVKDRWCVF DGFMVFCLWV
     SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS
     VSIFLLFFLL LYGILGVQMF GTFTYHCVVN DTKPGNVTWN SLAIPDTHCS PELEEGYQCP
     PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEASSQE GWVFLMYRAI DSFPRWRSYF
     YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGTRS STTSTATTQM FHEDAAGGWQ
     LVAVDVNKPQ GRAPACLQKM MRSSVFHMFI LSMVTVDVIV AASNYYKGEN FRRQYDEFYL
     AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVIG TTLHVYPDLY HSQFTYFQVL
     RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF
     PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPLVAIYFI LYHLFATLIL LSLFVAVILD
     NLELDEDLKK LKQLKQSEAN ADTKEKLPLR LRIFEKFPNR PQMVKISKLP SDFTVPKIRE
     SFMKQFIDRQ QQDTCCLFRI LPSTSSSSCD NPKRPTVEDN KYIDQKLRKS VFSIRARNLL
     EKETAVTKIL RACTRQRMLS GSFEGQPAKE RSILSVQHHI RQERRSLRHG SNSQRISRGK
     SLETLTQDHS NTVRYRNAQR EDSEIKMIQE KKEQAEMKRK VQEEELRENH PYFDKPLFIV
     GREHRFRNFC RVVVRARFNA SKTDPVTGAV KNTKYHQLYD LLGLVTYLDW VMITVTICSC
     ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI RDFGGVMDIF
     IYLVSLIFLC WMPQNVPAES GAQLLMVLRC LRPLRIFKLV PQMRKVVREL FSGFKEIFLV
     SILLLTLMLV FASFGVQLFA GKLAKCNDPN IIRREDCNGI FRINVSVSKN LNLKLRPGEK
     KPGFWVPRVW ANPRNFNFDN VGNAMLALFE VLSLKGWVEV RDVIIHRVGP IHGIYIHVFV
     FLGCMIGLTL FVGVVIANFN ENKGTALLTV DQRRWEDLKS RLKIAQPLHL PPRPDNDGFR
     AKMYDITQHP FFKRTIALLV LAQSVLLSVK WSVVITAPCS LVFKVFEYSF VLKVTMKIIA
     MSPAGFWQSR RNRYDLLVTS LGVVWVVLHF ALLNAYTYMM GACVIVFRFF SICGKHVTLK
     MLLLTVVVSM YKSFFIIVGM FLLLLCYAFA GVVLFGTVKY GENINRHANF SSAGKAITVL
     FRIVTGEDWN KIMHDCMVQP PFCTPDEFTY WATDCGNYAG ALMYFCSFYV IIAYIMLNLL
     VAIIVENFSL FYSTEEDQLL SYNDLRHFQI IWNMVDDKRE GVIPTFRVKF LLRLLRGRLE
     VDLDKDKLLF KHMCYEMERL HNGGDVTFHD VLSMLSYRSV DIRKSLQLEE LLAREQLEYT
     IEEEVAKQTI RMWLKKCLKR IRAKQQQSCS IIHSLRESQQ QELSRFLNPP SIETTQPSED
     TNANSQDHNT QPESSSQQQL LSPTLSDRGG SRQDAADTGK PQRKIGQWRL PSAAIAEKTA
     PVNKMSSYSQ DPEREEEEVS KGFLAPKPIS HSVSSVNLRF GGRTTMKSVV CKMNPMPDTA
     SCGSEVKKWW TRQLTVESDE SGDDLLDI
//
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