ID F1LT94_RAT Unreviewed; 1184 AA.
AC F1LT94;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Rho/Rac guanine nucleotide exchange factor 18 {ECO:0000313|Ensembl:ENSRNOP00000062255.2};
GN Name=Arhgef18 {ECO:0000313|Ensembl:ENSRNOP00000062255.2,
GN ECO:0000313|RGD:1311448};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000062255.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000062255.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000062255.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000062255.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000062255.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; NP_001100585.1; NM_001107115.1.
DR AlphaFoldDB; F1LT94; -.
DR SMR; F1LT94; -.
DR STRING; 10116.ENSRNOP00000062255; -.
DR PhosphoSitePlus; F1LT94; -.
DR PaxDb; 10116-ENSRNOP00000062255; -.
DR Ensembl; ENSRNOT00000066281.3; ENSRNOP00000062255.2; ENSRNOG00000028090.5.
DR KEGG; rno:304193; -.
DR UCSC; RGD:1311448; rat.
DR AGR; RGD:1311448; -.
DR CTD; 23370; -.
DR RGD; 1311448; Arhgef18.
DR eggNOG; KOG3520; Eukaryota.
DR GeneTree; ENSGT00940000157375; -.
DR HOGENOM; CLU_002466_0_0_1; -.
DR TreeFam; TF325887; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000028090; Expressed in spleen and 19 other cell types or tissues.
DR GO; GO:0045177; C:apical part of cell; ISO:RGD.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISO:RGD.
DR GO; GO:0030036; P:actin cytoskeleton organization; ISO:RGD.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; ISO:RGD.
DR GO; GO:0150105; P:protein localization to cell-cell junction; ISO:RGD.
DR GO; GO:0008360; P:regulation of cell shape; ISO:RGD.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; ISO:RGD.
DR CDD; cd15794; PH_ARHGEF18; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037744; ARHGEF18_PH.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47440:SF1; RHO_RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18; 1.
DR PANTHER; PTHR47440; RIKEN CDNA A430078G23 GENE; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 1184 AA; 132213 MW; 6446218CD63CE5CC CRC64;
MSISPGGPHS NLTWFEFLSE SEDGVCKNEK TDKSTRVKRS LSSLRSRVTR QKEKGKNPAH
LKDKIQDVPG KRECVNGHQL VRGTFSGHSS CPLCGKPLLS SAWSRTAHRF RLLGGRAEAA
RATREPAGRR AACEGPRGAS LKEHPRTALL SDGSSPAPSR NVGMTVSQKG GLQPTPSPAG
SGVRLGPIAG DMDEADSVFL KLKQTADDSL SLTSSNAESV FIEDPYTASL RCEIESDAHE
FEAESWSLSV DVAYAKKQKK EVVKRQDVLY ELMQTEAHHV RTLKIMLKVY SRALQEELQF
SVQAVSRLFP CADDLLDMHS HFLARLKERR QEFLEEDSDR NYVIQKIGDV LVQQFSGETG
ERMKEKYGVF CSGHKDAVGH YKLLLQQSKK FQNLIKKIGN FSIVRRLGVQ ECILLVTQRI
TKYPVLVERI IQNTEAGTED YKDLSQALNL IKDIISQVDA KVSECEKDQR LKEIVAKMDS
KSSGKLKNGR TFRKEDMLQR QLHLDSTLCW KSTSGRLKDV LAVLLTDVLL LLQEKDQKYV
FASVDSKPPV ISLQKLIVRE VANEEKAMFL ISASMQGPEM YEIYTSSKED RNIWMAHIRR
AVESCPDEEE GIFLEAEERR MAEARTMKLR DFQERLSLKD QLIAQSLLEK QQIYLEMAQL
SGLDESAQCR GLFRGGGDPS ETLRGEQILR SAMSEIEGIQ SLICRHVGST SSQVEEGGVS
AGLPRRAETF GGYDSVGSPN KGGSFKRKVY NSDPRPQDWQ GPASSPDSMP CDTTTPSGCC
EESPQAVEMP SAESSPCLPT VLESELVHRV QTLSQLLLSL QAVIAQQDSY VEMQRMAIQE
REKQFRLQST RGNLLLEQER QRNFEKQREE RAGVEKLQNQ LRQEQQRWER ERARQQQELE
LAGARLQERE GEARQLRQRL DQERTELERQ RQAYQHDLER LREAQRAVDR ERERLELLRR
FKKQNTVPGA LPPEVLAEAQ PASHPLNFNG DGLEGHLAPA KAPGTQGSML HGTGPEYGER
AEVARWDSAP AESRPAKSDV PIQLLSATNQ IQRQTAVQQQ IPTKLAASTK GGKDKNSKSR
GSQRWESSAS FDLKQQPLFN KLMGKDENAS RNRRSLSPVL PAAHGSAPAP DPCFPAPSPV
PAATAPEAFK SGGTSLPPAS PAPSLPTTPP TITDEVGKED VIFF
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