ID F1LUB9_RAT Unreviewed; 648 AA.
AC F1LUB9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Coiled-coil domain containing 38 {ECO:0000313|Ensembl:ENSRNOP00000031846.7};
GN Name=Ccdc38 {ECO:0000313|Ensembl:ENSRNOP00000031846.7,
GN ECO:0000313|RGD:1564046};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000031846.7, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000031846.7, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000031846.7,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000031846.7}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000031846.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001080322.1; XM_001080322.4.
DR RefSeq; XP_006226067.2; XM_006226005.3.
DR AlphaFoldDB; F1LUB9; -.
DR STRING; 10116.ENSRNOP00000031846; -.
DR PaxDb; 10116-ENSRNOP00000031846; -.
DR Ensembl; ENSRNOT00000030985.8; ENSRNOP00000031846.7; ENSRNOG00000021892.8.
DR AGR; RGD:1564046; -.
DR RGD; 1564046; Ccdc38.
DR VEuPathDB; HostDB:ENSRNOG00000021892; -.
DR eggNOG; ENOG502QSDI; Eukaryota.
DR GeneTree; ENSGT00940000153110; -.
DR HOGENOM; CLU_026271_1_0_1; -.
DR InParanoid; F1LUB9; -.
DR OMA; HSKPPSG; -.
DR TreeFam; TF328835; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000021892; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0002177; C:manchette; ISO:RGD.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0036126; C:sperm flagellum; ISO:RGD.
DR GO; GO:0061827; C:sperm head; ISO:RGD.
DR GO; GO:0035720; P:intraciliary anterograde transport; ISO:RGD.
DR GO; GO:0120316; P:sperm flagellum assembly; ISO:RGD.
DR GO; GO:0007283; P:spermatogenesis; ISO:RGD.
DR InterPro; IPR025252; DUF4200.
DR PANTHER; PTHR21683:SF7; COILED-COIL DOMAIN-CONTAINING PROTEIN 38; 1.
DR PANTHER; PTHR21683; UNCHARACTERIZED; 1.
DR Pfam; PF13863; DUF4200; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 197..315
FT /note="DUF4200"
FT /evidence="ECO:0000259|Pfam:PF13863"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 569..607
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 74710 MW; 34D34F54D7164B38 CRC64;
MASQLHVSRS SAEPGGRTPS QVHSARSSAE PGGRIPSQVH SARSSAEPGA RITYQLHSSR
SSAEPGARIT SQLHTSRSSA EPGGRISSQL QTSRSSGDEA KDAELKKERP YKIFFKDLFL
FKENEIAARK RERMKTHSMH IYQKTTFSSR MKSRSHLGQL AFFAEAGSSS YEKLGLDPTL
ILRLTEGADR KRTVHEFIND QRDRFLLEYA VSTKKNTIKR FERLIATKES QLKKAEKKLQ
DDALSFEEFL RENDQRSVDA LKMAAQETIN KLQMTSELKK AVMEVQAIKS EIAKTEFLLK
EYMKYGFFLL KLSPKQWQVQ QSQKRVQSSK SNQVLPKILE KFSICTSKRN NSTDSDRLSF
SEDRSSKRGS LGGRRRKSTL GQDSRRSSVL ARPESIASED SLEYFIEDEI VEFDLMPEIY
FKEPEELLQV LTELEEQNLT LVQYSQDVDE NLEDVNKRER FIQDKINNNI SFLLEHKNML
KVSCEREEEK AAELELRSRL FNFGEFNSDA QEKLIDSLSK KINQVYRVCI GDAEVGSLNA
IQKLVKVESR LVELSDLIES IPKENVEAIE RIKQKERRQK LREEKMREKQ RHQEERLKAA
LERAVAQPKK KLGRRLIYRS RPHSANKHEL LLIGDPRSKS QEEEYFFS
//
