ID F1LWV6_RAT Unreviewed; 1331 AA.
AC F1LWV6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Family with sequence similarity 205, member A {ECO:0000313|Ensembl:ENSRNOP00000060840.4};
GN Name=Spata31f1 {ECO:0000313|RGD:2320471};
GN Synonyms=Fam205a {ECO:0000313|RGD:2320471};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000060840.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000060840.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000060840.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000060840.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000060840.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the SPATA31 family.
CC {ECO:0000256|ARBA:ARBA00035009}.
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DR RefSeq; XP_006225314.1; XM_006225252.3.
DR RefSeq; XP_006238180.1; XM_006238118.3.
DR AlphaFoldDB; F1LWV6; -.
DR STRING; 10116.ENSRNOP00000060840; -.
DR PaxDb; 10116-ENSRNOP00000060840; -.
DR Ensembl; ENSRNOT00000068752.4; ENSRNOP00000060840.4; ENSRNOG00000042596.4.
DR KEGG; rno:100361292; -.
DR AGR; RGD:2320471; -.
DR CTD; 259308; -.
DR RGD; 2320471; Spata31f1.
DR VEuPathDB; HostDB:ENSRNOG00000042596; -.
DR eggNOG; ENOG502SM6T; Eukaryota.
DR GeneTree; ENSGT00950000183043; -.
DR HOGENOM; CLU_007854_0_1_1; -.
DR InParanoid; F1LWV6; -.
DR OMA; CRCHQKV; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000042596; Expressed in testis and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR039509; SPATA31.
DR InterPro; IPR027970; SPATA31F3-like.
DR PANTHER; PTHR21859; ACROSOME-SPECIFIC PROTEIN; 1.
DR PANTHER; PTHR21859:SF64; FAMILY WITH SEQUENCE SIMILARITY 205, MEMBER A1-RELATED; 1.
DR Pfam; PF15371; DUF4599; 1.
DR Pfam; PF14650; FAM75; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..138
FT /note="SPATA31F3-like"
FT /evidence="ECO:0000259|Pfam:PF15371"
FT DOMAIN 414..449
FT /note="SPATA31"
FT /evidence="ECO:0000259|Pfam:PF14650"
FT DOMAIN 474..603
FT /note="SPATA31"
FT /evidence="ECO:0000259|Pfam:PF14650"
FT REGION 798..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1058..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1331 AA; 149366 MW; B537992F9691CF57 CRC64;
MLSSTGFLWD TECSSYVYFY IFIIVLVVWQ VRQNYRGLKC EHKRSCCRRH QKVRQRARDA
ASRARRLSRE EAEKPWELLS IMKSQSWIPK EGSVRQLLCL DPGCQICEAA TLEIRQLLQS
EKNQLSPALL RLPQGSVCLE MLPISSESFQ WSEELYSGPS TNFPVAPGNQ TLTHLTEQFT
QSTSADGVQI CWTDHLQVGQ DFHPTDMPMA PETVMSSRLE ESAVFANEED MVDSNLNYIQ
QLQEHEALDS QFPFQTLNPQ ITHATHPMSV SIVTDVPQPF LSPEVLRLLE LHVKKLMHFQ
RWGLPRRVEE SLKQLMPNPP MYFQPEHNQP VPFILNTNSQ DYVHRFGGMS PQTWYSYMDR
QPIQTFWVSE WSSLDQRLPC KPIPSPMEKP LPIPDYELLV RDLCLLPKAQ ADDFQSNLQK
KFTQLFFGLP SMHSESLGST FLCTQGVSKD TFKPSYKDPP FLKELPLFPL PKAALPPSST
SPNESLCEHQ QRAQIGVPFL TLSECKTLEW HLLQRQLQLQ WGLPAVIPGS PYTQSHTQYK
LCNKAKPCET LKASRPRKSF SVLTRELFFI PRHARRLLEF HLQKQLIHQR WGLPQRIQHS
IHMLLSSPDQ QSLSCMGGSL PDVSISQPEN PEVDRSGGVF SSTAGKGSIP MPHLFAEAKA
ILKSHVHTKC EQIHKCKFPA CVQSSRDHRI PGNMAAGTLF PNIPQGQPLE LQAENNPDLH
QEVVPWKQMD LDQDTQAFSG AFIEHCRRPQ ALSEETIKKL ETTLRHKYLA FLSGLQALYC
VAPTRAISPT VDQFVITNMP RPVKSPQKPV RQKSPSEGPC LSGLVSGPQD DNETSANIEE
ELQPGVQMDG RTEKVPPERE PLLNRPYSFN TEIMEKLNFH LKKKVLEIKL GLPLKANALQ
ESSAADPESD SIQESLGSPC LSESTLFQEQ PASGDLPPAP DPNEVHLELP ATAVPAAFQE
QERPSSRAVP HSSAPQGPRP LYFYRNMIEA QVHYVQMGTG EETPNLGEPF STESQSSRKS
KSSGHVPTMT GRNLGKPKAA GDLGEGDAGL LLSLVSQKPH QDGELEVEKK TLHRTPQGSS
QQGHNFQPEG VCPHSPRESP ELEFPAPPPE IFMEIDSEQD TEDSQIEDSI VLEAARIAEV
PHSEVSQASQ ASQTSQASQA PQGLPSPCSP IQRKPFQAQP CPGHFSPGRM MPASPNTRPS
HLPEAGLKNK MKFFLHSINP KTKSRTYTEP PVVFTPGKVA KTSKENVERG LLRTKSPTKK
TRSEDFRGPK AQSLSSEKPV IAPYLTPSYI LDSKFWPRSR QLGPVSVLGS SHYCPRHCPR
LAYATQQRNP P
//
