ID F1M111_RAT Unreviewed; 1749 AA.
AC F1M111;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Myosin VC {ECO:0000313|Ensembl:ENSRNOP00000011768.7};
GN Name=Myo5c {ECO:0000313|Ensembl:ENSRNOP00000011768.7,
GN ECO:0000313|RGD:1309994};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000011768.7, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000011768.7, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000011768.7,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000011768.7}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000011768.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_006226541.1; XM_006226479.2.
DR RefSeq; XP_006243475.1; XM_006243413.2.
DR AlphaFoldDB; F1M111; -.
DR STRING; 10116.ENSRNOP00000011768; -.
DR iPTMnet; F1M111; -.
DR PhosphoSitePlus; F1M111; -.
DR PaxDb; 10116-ENSRNOP00000011768; -.
DR Ensembl; ENSRNOT00000011768.8; ENSRNOP00000011768.7; ENSRNOG00000008356.8.
DR GeneID; 315820; -.
DR UCSC; RGD:1309994; rat.
DR AGR; RGD:1309994; -.
DR CTD; 55930; -.
DR RGD; 1309994; Myo5c.
DR VEuPathDB; HostDB:ENSRNOG00000008356; -.
DR eggNOG; KOG0160; Eukaryota.
DR GeneTree; ENSGT00940000157971; -.
DR HOGENOM; CLU_000192_9_4_1; -.
DR InParanoid; F1M111; -.
DR OMA; EIMFDDR; -.
DR OrthoDB; 1094820at2759; -.
DR TreeFam; TF328771; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000008356; Expressed in lung and 16 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd15476; Myo5c_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.220.10; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037991; Myo5c_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF313; UNCONVENTIONAL MYOSIN-VC; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 5.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 8..62
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 67..753
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1428..1704
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 632..654
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1232..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 884..1098
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1310..1358
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 161..168
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1749 AA; 203144 MW; 6B108B732A4EA12B CRC64;
MAVAELYAQY NRVWIPDPEE VWKSAEIAKD YRVGDQVLRL LLEDGTELDY PVDPGSLPPL
RNPDILVGEN DLTALSYLHE PAVLHNLRIR FAESKLIYTY SGIILVAMNP YKQLPIYGDA
IIHAYSGQNM GDMDPHIFAV AEEAYKQMAR NNRNQSIIVS GESGAGKTVS ARYAMRYFAT
VSKSSSNAHV EEKVLASNPI TEAVGNAKTT RNDNSSRFGK YTEISFDERN QIIGANMRTY
LLEKSRVVFQ SENERNYHIF YQLCASAQQS EFKHLKLGSA EEFNYTRMGG NTVIEGVDDR
ADMAETQKTF TLLGFKKDFQ MDVFKILAAI LHLGNVQVTT VGNERSAVSE DDSHLKVFCE
LLGLETIKVA QWLCNRKIVT SSETVVKPMT RPQAINARDA LAKKIYAHLF DFIVEQINQA
LHFSGKQHTF IGVLDIYGFE TFDVNSFEQF CINYANEKLQ QQFNLHVFKL EQEEYMKEDI
PWTLIDFYDN QPVIDLIEAK MGILELLDEE CLLPHGTDEN WLQKLYNNFV NKNSLFEKPR
MSNSSFIIQH FADKVEYQCE GFLEKNRDTV YDMLVEVLRA SKFHLCAAFF QESPVPSSPF
GAMITVKSAK QVIKPNTKHF RTTVGNKFRS SLFLLMETLN ATTPHYVRCI KPNDEKLPFE
FDSKRIVQQL RACGVLETIR ISAQSYPSRW TYLEFYSRYG VLMTQQELSL SDKKEVCKVV
LHRLIQDSNQ YQFGRTKIFF RAGQVAYLEK LRLDKLRQGC IVIQKHVRGW LQRKKFLRER
RAALTIQQYF RGQQTVRKAI TATALKEAWA AIILQKHCRG YLVRNLYQLI RVATITIQAH
TRGFLARRRY RKLLQEHKAV ILQKYARAWL ARRRFQNIRR FVLNIQLTYR VQRLQKKLED
QNRENHGLVE KLTSLAALRV GDLEKVQRLE AELEKAATHR HSYEEKGRRY RDSMEERLSK
LQKHNAELES QRERAEQSLQ ERTEELKEKM DQLTRQLFDD VQKEEQQRLL LEKSFELKTQ
AYEKEIESLR EEIKALKDER TQLHHQLEEG RVTSDSLKGE VARLSKQAKT ISEFEKEIEL
LQAQKIDVEK HVQSQKREMR ERMSEVTKQL LESYDIEDVR SRLSVEDLEH LNEDGELWFA
YEGLKKATRV LESHFQSQKD CYEKEIEGLN FKVVHLSQEI NHLQKLFREE TDINESIRHE
VTRLTSENMM IPDFKQQISE LERQKQDLES RLKEQAEKME GKQEEPFSHL NRGLEEEGRQ
GKAPRPFLRA VEAQSETHPE GKERLVGKIQ EPQEAIKFPK KQAEAEEEVE SILRQEASRL
SLENRDLEEE LDMKDRMIRK LQDQVKTLTR TIEKANSVPL PSGSREYLGM LEYKKEDETK
LIQNLILDLK PRGVVVNMIP GLPAHILFMC VRYADSLNDA NMLKSLMNSA INGIKHVVKE
HFEDLEMLSF WLSNTCHFLN CLKQYSGEEE FMKCNSPQQN KNCLNNFDLT EYRQILSDVA
IRIYHQFILV MENNLQPIIV PGMLEYESLQ GISGLKPTGF RKRSSSIDDT DAYTMTSILQ
QLSYFYSTMC QNGLDPEIVR QAVKQLFYLI GAVTLNSLLL RKDMCSCRKG MQIRCNISFL
EEWLKDKNLQ NSLAKETLEP LSQAAWLLQV KKTTDSDAKE ISQCCTSLSA VQIIKILNSY
TPIDDFEKRV NPSFVRKVQA LLNNRGDSSQ LMLDTKYLFQ VTFPFTASPH ALEMTQIPSS
FKLGFLRRL
//