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Database: UniProt
Entry: F1MB07_BOVIN
LinkDB: F1MB07_BOVIN
Original site: F1MB07_BOVIN 
ID   F1MB07_BOVIN            Unreviewed;       911 AA.
AC   F1MB07;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   12-SEP-2018, entry version 60.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LIG4 {ECO:0000313|Ensembl:ENSBTAP00000021092,
GN   ECO:0000313|VGNC:VGNC:30884};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000021092, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000021092, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021092,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000021092}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000021092};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; DAAA02034872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001178055.1; NM_001191126.1.
DR   RefSeq; XP_005214056.1; XM_005213999.2.
DR   RefSeq; XP_005214057.1; XM_005214000.3.
DR   RefSeq; XP_010809287.1; XM_010810985.2.
DR   RefSeq; XP_010809288.1; XM_010810986.2.
DR   RefSeq; XP_015329419.1; XM_015473933.1.
DR   UniGene; Bt.7959; -.
DR   ProteinModelPortal; F1MB07; -.
DR   STRING; 9913.ENSBTAP00000021092; -.
DR   PaxDb; F1MB07; -.
DR   Ensembl; ENSBTAT00000021092; ENSBTAP00000021092; ENSBTAG00000015868.
DR   GeneID; 781252; -.
DR   KEGG; bta:781252; -.
DR   CTD; 3981; -.
DR   VGNC; VGNC:30884; LIG4.
DR   eggNOG; KOG0966; Eukaryota.
DR   eggNOG; COG1793; LUCA.
DR   GeneTree; ENSGT00860000133881; -.
DR   InParanoid; F1MB07; -.
DR   KO; K10777; -.
DR   OMA; HMCPSTK; -.
DR   OrthoDB; EOG091G03K0; -.
DR   TreeFam; TF312980; -.
DR   Reactome; R-BTA-5693571; Nonhomologous End-Joining (NHEJ).
DR   Proteomes; UP000009136; Chromosome 12.
DR   Bgee; ENSBTAG00000015868; Expressed in 10 organ(s), highest expression level in liver.
DR   GO; GO:0000793; C:condensed chromosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR   GO; GO:0032807; C:DNA ligase IV complex; IBA:GO_Central.
DR   GO; GO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
DR   GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR   GO; GO:0051276; P:chromosome organization; IEA:Ensembl.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051102; P:DNA ligation involved in DNA recombination; IEA:Ensembl.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0097680; P:double-strand break repair via classical nonhomologous end joining; IEA:Ensembl.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
DR   GO; GO:0033152; P:immunoglobulin V(D)J recombination; IBA:GO_Central.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0006297; P:nucleotide-excision repair, DNA gap filling; IBA:GO_Central.
DR   GO; GO:2001252; P:positive regulation of chromosome organization; IEA:Ensembl.
DR   GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
DR   GO; GO:0002328; P:pro-B cell differentiation; IEA:Ensembl.
DR   GO; GO:0010332; P:response to gamma radiation; IEA:Ensembl.
DR   GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR   GO; GO:0000012; P:single strand break repair; IEA:Ensembl.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
DR   GO; GO:0033077; P:T cell differentiation in thymus; IEA:Ensembl.
DR   GO; GO:0033153; P:T cell receptor V(D)J recombination; IEA:Ensembl.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN      355    489       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      654    743       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      808    911       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      872    892       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   911 AA;  103876 MW;  7E570BBFAE1DB6C6 CRC64;
     MAASQTSQTV ASHVPFADLC STLERIQKSK GRAEKIRHFK AFLDSWRKFH NALHKNQKDV
     TDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP RDGKDALKLL NYRTPTGTRG
     DAGDFAMIAY FVLKPRCLQK GSLSIQQVND ILDSIASNNS AKRKDLMKKS VLQLITQSSA
     LEQKWLIRMI VKDLKLGFSQ QTIFSIFHSD AAELHNVTTD LEKVCRQLHD PSVGLSDISI
     TLFSAFKPML AAIADIERIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYRY FSRNGYNYVD
     QFGASPQEGS LTPFIHNAFK TEVLNCILDG EMMAYNPNTQ TFMQKGNKFD IKRMVEDSEL
     QTCYCVFDVL MVNDKKLGHE TLRKRYEILN SVFTPVPGRI EIVQKTQAHT KKEVIDALNE
     AIDKREEGIM VKHPLSIYKP DKRGEGWLKI KPEYVNGLMD ELDILIIGGY WGKGARGGMM
     SHFLCAVSEK PPSGEKPSVF HTLCRVGSGY TMKELYDLGL KLAKHWKPFH RKAPPSNILC
     GTEKPEVYIE PCNSVIVQVK ATEIVPSDMY KTGCTLRFPR IEKIREDKEW YECTSLEDLE
     QLRGKACGKL ASRHLYLGGD DEPQEKKRKA APKMKKVIGI IEHLKAPNLS NVNRVSTVFE
     DVEFCVMSGT SSHPKPDLEN RIAELGGYIV QNPGPDTYCV IAGSENIRVK NIISSDKHDV
     VKPEWLLECF RTRSCVPWQP RFMIHMCPST KQHFAQEYDQ YGDSYFVDTD LHQLKEVFLG
     IKNAGEQTPG EMSPVIADLE HRYSWASAPL SMFRHLTVYL DLYAVINDLS TRIKGARLAI
     TALELRFHGA QVVSCLAEGV SHVIVGEDQS RVADLKAIRR TLKRKFKILQ ERWVTVSIDK
     CELQEENRYL V
//
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