ID F1MCL8_BOVIN Unreviewed; 1454 AA.
AC F1MCL8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Rho GTPase activating protein 31 {ECO:0000313|Ensembl:ENSBTAP00000000253.5};
GN Name=ARHGAP31 {ECO:0000313|Ensembl:ENSBTAP00000000253.5,
GN ECO:0000313|VGNC:VGNC:26089};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000000253.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000000253.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000253.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000000253.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000000253.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F1MCL8; -.
DR STRING; 9913.ENSBTAP00000000253; -.
DR PaxDb; 9913-ENSBTAP00000000253; -.
DR Ensembl; ENSBTAT00000000253.5; ENSBTAP00000000253.5; ENSBTAG00000000210.5.
DR VEuPathDB; HostDB:ENSBTAG00000000210; -.
DR VGNC; VGNC:26089; ARHGAP31.
DR eggNOG; KOG1449; Eukaryota.
DR GeneTree; ENSGT00940000159458; -.
DR HOGENOM; CLU_006917_0_0_1; -.
DR InParanoid; F1MCL8; -.
DR OMA; TVMSLWT; -.
DR TreeFam; TF351451; -.
DR Reactome; R-BTA-8980692; RHOA GTPase cycle.
DR Reactome; R-BTA-9013148; CDC42 GTPase cycle.
DR Reactome; R-BTA-9013149; RAC1 GTPase cycle.
DR Reactome; R-BTA-9013420; RHOU GTPase cycle.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000000210; Expressed in theca cell and 105 other cell types or tissues.
DR ExpressionAtlas; F1MCL8; baseline.
DR GO; GO:0030027; C:lamellipodium; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IBA:GO_Central.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF3; RHO GTPASE-ACTIVATING PROTEIN 31; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 17..219
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 507..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..708
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..803
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..1001
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1262..1277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1326..1340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1454 AA; 158072 MW; 4C1F3969DE3A7A19 CRC64;
MLLTEAQLSY NYGALALGLY DPVKSPFLGP TSQPFAVPYV LKSCAEFIET HGIVDGIYRL
SGVTSNIQRL RQEFGSDQCP DLTREVYLQD IHCVGSLCKL YFRELPNPLL TYELYEKFTE
AVSHCPEEGQ LARIQNVIQE LPPSHYRTLE YLIRHLAHIA SFSSKTNMHA RNLALVWAPN
LLRSKEIEAT GCNGDAAFLA VRVQQVVIEF ILNHVDQIFN NGTPGSLEND ENRPIMKSLT
LPALSLPMKL VSLEEAQARS LATNHPARKE RRENSLPEIV PPMGTLFHTV LELPDNKRKL
SSKSKKWKSI FNLGRSGSDS KSKLSRNGSV FVRGQRLSVE KATIRPAKSM DSLCSVPVEG
KETKGNFNRT VTTGGFFIPA AKMHSTSTGS SCDLSKQEGE WGQEGMPAGA EGGFDVGGDR
SQPQGAQARG PPEQLKVFRP IEDPESEQTA PKMLGMFYTS NDSPSRSVFT SSLFQMEPSP
RHQRKALNIS KPFAVSVPLR VSAVISTNST PCRTPPKELQ SLSSLEEFSF QGSDSGDWPE
EEKPLSAETS TASVPKKAAL ENTKPGPDTV RTLECSKGLP LEPGTQVEEK KTSESPLGSQ
HSSELEKKLD EEKVVEESGE TSQVAASALQ ENPGARAEAV FLHEMDEDDL VNALIWSEIQ
QELKIIESEE ELSSLAPPAL KISPTQPILE SSPGPFASPE PPGSSTPAPV SAPLEEWTKN
PTNQSTLGTS TAANREKLET AGILPRSEPD PEKGQRPDPA SLTPLEIVPL EKSSPQTRME
VGAPGNLSPL LPPAAPPPTP LEEEPRVQLL KSGPEREDSS GNLRTNPYAD QMKSKGSPEI
PSLCQGDKAS SEESEKQNSK NPAPESKGSS FPSPTREAEI SPQGEEDVAH SVQEPSDCDD
DDTVTDIAQH GLEMVEPWEE PQWVTSPLHS PTLKDVQETQ MQGPQGHRLE KRLSHRPSLR
QSHSLDGKTM VKSQWTLKGS SSSSCADLEA ERNSNPLQPL APRSEITGWD EKAKRSFQEL
SGLKRTEVPP KQKAPGGSQP ASAESSPVGL AEGKELGPHV GPHNPRVEPG GDPEPDSSKE
NSPGVQDHTS PGEHPPKFQR KSSEGGAPKG KNRPSSLNLD STIPIIDLFR FENAASFGSP
EVHLSEPGDP KVTWLTSSHG KVDPWRVYSQ DSQDLDMVAH ALTGRRNSAP VSVSAVRTSF
MVKMCQARAV PVIPPKIQYT QIPQPLPSQS SEESGAQPLE RNQEEAGSTG GTSQKLTKDD
SLSSLESPRE EKPKQDTGAI ESLPVDTTAS HVCEGPTLPP EPGLANLLTT QDAVVQCRKR
TSETEPSGDN LLSSKIERSS GGSKPFHRSR PGRPQSLILF SPPFPIMDHP PPSSTGTDSK
VLLSPIRSPT QTISPGLLCG ELAENTWVTP EGVTLRNKMT IPKNGQRLET STSCFYQPQR
RSVILDGRSG RQIE
//
