ID F1MEC8_BOVIN Unreviewed; 1070 AA.
AC F1MEC8;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Protocadherin 8 {ECO:0000313|Ensembl:ENSBTAP00000024190.5};
GN Name=PCDH8 {ECO:0000313|Ensembl:ENSBTAP00000024190.5,
GN ECO:0000313|VGNC:VGNC:32622};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000024190.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000024190.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000024190.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000024190.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000024190.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1MEC8; -.
DR SMR; F1MEC8; -.
DR STRING; 9913.ENSBTAP00000024190; -.
DR PaxDb; 9913-ENSBTAP00000024190; -.
DR Ensembl; ENSBTAT00000024190.6; ENSBTAP00000024190.5; ENSBTAG00000018179.6.
DR VEuPathDB; HostDB:ENSBTAG00000018179; -.
DR VGNC; VGNC:32622; PCDH8.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000155219; -.
DR HOGENOM; CLU_006480_1_2_1; -.
DR InParanoid; F1MEC8; -.
DR OMA; GESSCHF; -.
DR OrthoDB; 4259465at2759; -.
DR TreeFam; TF352008; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000018179; Expressed in Ammon's horn and 30 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Ensembl.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF46; PROTOCADHERIN-8; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1070
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003266235"
FT TRANSMEM 748..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..135
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 136..245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 247..354
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 399..495
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 496..607
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 613..721
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 715..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 906..928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1070 AA; 112792 MW; DD139F99769462B2 CRC64;
MSPARRGGSP CLFPLQLFSL CWVLSVAQSK TVRYSTFEED APGTVIGTLA EDLHMKVSGD
TSFRLMKQFN SSLIRVREGD GQLTVGDAGL DRERLCGQAP QCVLAFDVVS FSQEQFRLVH
VEVSVRDIND HAPRFPRAQI PVEVSEGAAV GTRIPLEVPV DEDVGANGLQ SVRLAEPHSP
FRVELQTRAD GAQCADLVLL QELDRESQAT YSLGLVAQDG GRPPRSATAA LSVRVLDAND
HSPAFPQGAV AEVELAEDAP VGSLLLDLDA ADPDEGPNGD VVFAFGARTP PEARRLFRLD
PRSGRLTLAG PVDYERQDTY ELDVRAQDRG PGPRAATCKV IVRLRDVNDN APDISITPLA
APGAPAASPF PAAAAALGGA EATSSTGPGT PEAGAVSLVP EGAARESLVA LVSTSDRDSG
ANGQVRCALY GHEHFRLQPA YAGSYLVVTA ASLDRERISE YNLTLVAEDR GAPPLRTVRP
YTVRVGDEND NAPLFTRPVY EVSVRENNPP GAYLATVAAR DPDLGRNGQV TYRLLEAEVG
RAGGAVSTYV SVDPATGAIY ALRSFDYETL RQLDVRIQAS DGGSPQLSSS ALVQVRVLDQ
NDHAPILVHP APANGSLEVA VPGRTAKDTA VARVQARDAD EGANGELAFD LLQQEPREAF
AIGRRTGEIV LTGDLSQEPP GRVFRALLVI SDGGRPPLST TATVSFVVTA GGGRGLASPA
GAGNPERSRP PGSRLATSGP ALQWDTPLII IIVLAGSCTL LLAAIIAIAT TCNRRKKEVR
KGGPRREERP GAAGGVASAP GSPEEAARGA GPRPNMFDVL TFPGSGKAPF GSPAADAPPP
AVAAAAEVPG SEGGGATGES ACHFEGQQRL RGAHAEPYGA SPGFGKEPAP PVAVWKGHSF
NTISGREAEK FSGKDSGKGD SDFNDSDSDI SGDALKKDLI NHMQSGLWAC TAECKILGHS
DRCWSPSCAG GPSTHASTHP PAQMSTFCKS TSLPRDPLRR DSYYQAQLPK TVGLQSVYEK
VLHRDYDRTA TLLSPPRPGR LPDLQEIGVP LYPSPPGRYL SPKKEANENV
//
