ID F1MEQ5_BOVIN Unreviewed; 651 AA.
AC F1MEQ5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Aspartyl-tRNA synthetase 2, mitochondrial {ECO:0000313|Ensembl:ENSBTAP00000005704.5};
GN Name=DARS2 {ECO:0000313|Ensembl:ENSBTAP00000005704.5,
GN ECO:0000313|VGNC:VGNC:27882};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005704.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005704.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005704.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005704.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005704.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Type 1 subfamily. {ECO:0000256|ARBA:ARBA00006303}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005217160.1; XM_005217103.3.
DR RefSeq; XP_005217161.1; XM_005217104.2.
DR RefSeq; XP_010811649.1; XM_010813347.2.
DR RefSeq; XP_015330639.1; XM_015475153.1.
DR AlphaFoldDB; F1MEQ5; -.
DR SMR; F1MEQ5; -.
DR Ensembl; ENSBTAT00000005704.6; ENSBTAP00000005704.5; ENSBTAG00000004358.6.
DR GeneID; 538772; -.
DR CTD; 55157; -.
DR VEuPathDB; HostDB:ENSBTAG00000004358; -.
DR VGNC; VGNC:27882; DARS2.
DR GeneTree; ENSGT01030000234618; -.
DR HOGENOM; CLU_014330_3_1_1; -.
DR InParanoid; F1MEQ5; -.
DR OMA; YQLDVEM; -.
DR TreeFam; TF314827; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000004358; Expressed in rumen papilla and 103 other cell types or tissues.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0004815; F:aspartate-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0050560; F:aspartate-tRNA(Asn) ligase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0006422; P:aspartyl-tRNA aminoacylation; IBA:GO_Central.
DR GO; GO:0070145; P:mitochondrial asparaginyl-tRNA aminoacylation; IEA:Ensembl.
DR CDD; cd00777; AspRS_core; 1.
DR CDD; cd04317; EcAspRS_like_N; 1.
DR Gene3D; 3.30.1360.30; GAD-like domain; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00044; Asp_tRNA_synth_type1; 1.
DR InterPro; IPR004364; Aa-tRNA-synt_II.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004524; Asp-tRNA-ligase_1.
DR InterPro; IPR047089; Asp-tRNA-ligase_1_N.
DR InterPro; IPR002312; Asp/Asn-tRNA-synth_IIb.
DR InterPro; IPR047090; AspRS_core.
DR InterPro; IPR004115; GAD-like_sf.
DR InterPro; IPR029351; GAD_dom.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR NCBIfam; TIGR00459; aspS_bact; 1.
DR PANTHER; PTHR22594:SF5; ASPARTATE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22594; ASPARTYL/LYSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF02938; GAD; 1.
DR Pfam; PF00152; tRNA-synt_2; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR PRINTS; PR01042; TRNASYNTHASP.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF55261; GAD domain-like; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 184..602
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 651 AA; 73748 MW; 5E58AC3A2FE9A5D3 CRC64;
MFCWLSRLCG ELSTPTRRTT QLIWSSAARS MVLSSQRIPE LSSFVARTNT CGELRSSHLG
QEVTLCGWIQ FRRQNIFLVL RDFHGLVQVV IPQDESAASV KKILCEAPME SVVQVSGTVI
SRPPGQKNPK MPTGEIEIKV KTAKLLNSCK KLPFEIKDFM KKTETLRLQY RYLDLRSVQM
QYNLRLRSQM VMKMREYLCN LHGFVDVETP TLFKRTPGGA KEFVIPSREP GKFYSLPQSP
QQFKQLLMVG GLDRYFQVAR CYRDEGSRPD RQPEFTQIDI EMSFVDQTGV QSLIEGLLQY
SWPSDKDPLV VPFPSMPFAE ALASYGTDKP DTRFGMKIVD ISDMFRNTEV GFLQDALSKP
QGTVKAICIR KGAKYLKRKD IESIRKFAAD HFNEEVLPIF LKTNENWNSP VAKFIMEEQG
LGLVKLLETQ EEDVVLLTAG EHKKACSLMG KLRLECADLL EARGVVLRDP ALFSFLWVVD
FPLFLPKEEN PQELESAHHP FTAPHPSDIH LLYTEPHKVR SQHYDLVLNG NEIGGGSIRI
HNSELQHYVL DTVLKEDVKL LSHLLQALDY GAPPHGGIAL GLDRLMCLVT GAPSIRDVIA
FPKSFRGHDL MSNAPDSIPP EELKPYHIQV SWPMDAETEK SSSNHPCRSE S
//
