ID F1MER9_BOVIN Unreviewed; 799 AA.
AC F1MER9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=STAT5A {ECO:0000313|Ensembl:ENSBTAP00000034715.4,
GN ECO:0000313|VGNC:VGNC:35372};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000034715.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000034715.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000034715.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000034715.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000034715.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR AlphaFoldDB; F1MER9; -.
DR Ensembl; ENSBTAT00000034831.4; ENSBTAP00000034715.4; ENSBTAG00000009496.6.
DR VEuPathDB; HostDB:ENSBTAG00000009496; -.
DR VGNC; VGNC:35372; STAT5A.
DR GeneTree; ENSGT01080000257420; -.
DR HOGENOM; CLU_014189_2_2_1; -.
DR OMA; EYGEFYY; -.
DR TreeFam; TF318648; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000009496; Expressed in parenchyma of mammary gland and 105 other cell types or tissues.
DR ExpressionAtlas; F1MER9; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0030222; P:eosinophil differentiation; IEA:Ensembl.
DR GO; GO:0035723; P:interleukin-15-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0038110; P:interleukin-2-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0038156; P:interleukin-3-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0035771; P:interleukin-4-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0038043; P:interleukin-5-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0038113; P:interleukin-9-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
DR CDD; cd10376; SH2_STAT5; 1.
DR CDD; cd16855; STAT5_CCD; 1.
DR CDD; cd16849; STAT5_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR046994; STAT5_CCD.
DR InterPro; IPR035858; STAT5a/5b_DBD.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF47; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Lactation {ECO:0000256|ARBA:ARBA00043262};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 589..686
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 774..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 91267 MW; 931E2A3CCED084DD CRC64;
MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRAQATQL
LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV
REANNGSSSA GILVDAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL
RIQAQFAQLA QLNPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL
RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL
NVHMNPPQVK ATIISEQQAK SLLKNENTRN ECSGEILNNC CVMEYHQATG TLSAHFRNMS
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNS
SSSHLEDYNG MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRD FSIRSLADRL
GDLNYLIYVF PDRPKDEVFS KYYTPVFCEQ ATAKAVDGYV KPQIKQVVPE FVSASADSAG
SNATYMDQAP SPAVCPQPHY NMYPQNPDPV LDQDGEFDLD ETMDVARHVE ELLRRPMDSL
EPSLPPPTGL FTPGRGSLS
//