ID F1MF78_BOVIN Unreviewed; 6919 AA.
AC F1MF78;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Spectrin repeat containing nuclear envelope protein 2 {ECO:0000313|Ensembl:ENSBTAP00000029285.6};
GN Name=SYNE2 {ECO:0000313|Ensembl:ENSBTAP00000029285.6,
GN ECO:0000313|VGNC:VGNC:35521};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000029285.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000029285.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029285.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000029285.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029285.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004605}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004605}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004605}.
CC -!- SIMILARITY: Belongs to the nesprin family.
CC {ECO:0000256|ARBA:ARBA00008619}.
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DR RefSeq; NP_001193515.1; NM_001206586.1.
DR SMR; F1MF78; -.
DR STRING; 9913.ENSBTAP00000029285; -.
DR PaxDb; 9913-ENSBTAP00000029285; -.
DR Ensembl; ENSBTAT00000029285.6; ENSBTAP00000029285.6; ENSBTAG00000025450.5.
DR GeneID; 540504; -.
DR KEGG; bta:540504; -.
DR CTD; 23224; -.
DR VEuPathDB; HostDB:ENSBTAG00000025450; -.
DR VGNC; VGNC:35521; SYNE2.
DR eggNOG; KOG0516; Eukaryota.
DR GeneTree; ENSGT00940000154656; -.
DR HOGENOM; CLU_000034_2_0_1; -.
DR InParanoid; F1MF78; -.
DR OMA; NEANYID; -.
DR OrthoDB; 5478539at2759; -.
DR TreeFam; TF329280; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000025450; Expressed in spiral colon and 113 other cell types or tissues.
DR GO; GO:0031527; C:filopodium membrane; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0031258; C:lamellipodium membrane; IEA:Ensembl.
DR GO; GO:0034993; C:meiotic nuclear membrane microtubule tethering complex; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0031981; C:nuclear lumen; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0140444; F:cytoskeleton-nuclear membrane anchor activity; IEA:Ensembl.
DR GO; GO:0051642; P:centrosome localization; IEA:Ensembl.
DR GO; GO:0031022; P:nuclear migration along microfilament; IEA:Ensembl.
DR GO; GO:0021817; P:nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:1902017; P:regulation of cilium assembly; IEA:Ensembl.
DR CDD; cd21242; CH_SYNE2_rpt1; 1.
DR CDD; cd21244; CH_SYNE2_rpt2; 1.
DR CDD; cd00176; SPEC; 6.
DR Gene3D; 1.20.58.60; -; 14.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR039906; Anc-1/SYNE1/2-like.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR012315; KASH.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR21524; SPECTRIN REPEAT CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR PANTHER; PTHR21524:SF6; SPECTRIN REPEAT-CONTAINING NUCLEAR ENVELOPE PROTEIN 2; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF10541; KASH; 1.
DR Pfam; PF00435; Spectrin; 3.
DR SMART; SM00033; CH; 2.
DR SMART; SM01249; KASH; 1.
DR SMART; SM00150; SPEC; 21.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 19.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS51049; KASH; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00385}; Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT TOPO_DOM 1..6868
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT TOPO_DOM 6890..6919
FT /note="Perinuclear space"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00385"
FT DOMAIN 31..136
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 181..286
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 6860..6919
FT /note="KASH"
FT /evidence="ECO:0000259|PROSITE:PS51049"
FT REGION 1044..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4123..4143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4420..4448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6357..6445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6474..6493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6796..6858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 950..1036
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1469..1503
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1671..1698
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2331..2365
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3126..3159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3333..3360
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3400..3427
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3492..3541
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3699..3726
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3864..3912
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4039..4088
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4503..4537
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4673..4700
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5217..5283
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5818..5877
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 4125..4139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6357..6389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6919 AA; 797779 MW; 8E4C13F8EC4AA1CB CRC64;
MASSPVLPAE DQQVSLGIDD LHFSLQAEQE DTQKKTFTCW INSQLAKHTP PSVVTDLFTD
IKKGHVLLDL LEVLSGQQLP RDKGSNTFQC RINIENALTF LQNQSIKLIN IHVTDIIDGN
PSIVLGLIWT IILHFHIEEL ARTLPGNYSQ PSLDSVSAVD SSPTSSPPAK KCSKVQERWR
MSAKKALLQW AQEQCASYES VNVTDFKSSW RNGMAFLAVI HALRPDLIDM KSVKHRSNRD
NLKEAFRIAE QELKIPKMLE PEDVDVVNPD EKSIMTYVAQ FLQYSKKAPG SGDEAQGKVK
DAMVWLALQE KKVHKMLTDS ENETYCKTYE SLLSFLESFN KEKERFLDVL TIKRNVDDLN
KDQLQLREAW DGLNYQINVW QTELNRVLPS PLYQIETWLQ EVEKLIDEDL SVSQDYSEAM
ALTQEKITLF QSLMDKFDCH LNTLLAFENR DENHLPLVPP EKLEEMKRRI NNISGKKVIP
RLEFHYYECS VLGLLEEVKS KLLVWNIKYG SKESVELLLE DWHKFIEEKE FLAQLETSFQ
KCEEIHNNLA GEYPNISKQY TMVKYHFSMY RENILNVKST LQKVLACWAT YVENLRLLKA
CFEETKKEQM KEVPFETLSQ WNLQHTTLNE VGNFLFQVSN DEVGSSISKE LKRLNKRWRK
LITKAQPEVN LPLMKLQDEP FLDNSGNIQL SKEENLAVGF STYRSSELPE NHNQNIMAGE
VHEKENEDFS GPLKVAKEVE KLIGQVETWE AETTSVLDLL RQQDDVETSV EESLQHLIAK
GSMYEELVSR IEDTLQMDVQ HVSSQESLQH VLTAGLQAKI QEAKEKVQIS MIKLVAVLKN
STDVSQDLDV RLKVEETQKE LESYITRAEQ LLGQKESQRG LITKYKEALI ISNTKSLAKY
LKAVEELKNN VTDDVKLSLE EKSRDICAKW ESLHHEMSLY IQQLKIDIEK GKLSDSIAKL
EKQINKEKKL IRRGRTKGLI KEHEACFSEE GSLYQLDHHM DVLRELCEEL TSQKSQQEVR
RALKDYEQKI ERLRKCASEI HMTLQPTLGG TSKNKGTTDA SKNGGGNTLS EVPSAKSDNQ
PSAEKAMELV QNFHLESKLK LQQEESIMEK YEKGHSTSID SLLERYDTHK GTLELYLQNS
IARITSDFSS DKERSSVCLQ DKLTDLQVLK NETDACWKEF EITSLKLEEL ESDIKKPFIV
KARDKLKEKE RELQMALKSR MESLETVLKM VLPMEKESLL LCDTDLLLRE MAIQEFHLTD
ADDIYQNLRN IQDSVVKQIE TCKNLGQSGN FALKELHPLD LHAAQNIILK HRTQLEEMNH
RVQKSKDALE ALEDFLASLR AAELSSELLT DHSASDSQGV PANTLTVENK EREIHRMRDK
ARHLDEHLKM LGISIKDSEQ GENTSCEKLL DALSKNLSET RSGGQEEVTE EDKLLGACVS
KNDELLKNIQ DVHNQISKIG LKDPTVPAIK QRRKSLIRLD KDLDEYEEEK KHLQEMVNSL
LQFKDGRNKA LSQRCQDTAV LWENVKTLVT ECLDQCERVL ELLKQYQNFK SVLTTLIQKE
ENVLSVQASY MGKENLKKRI AEIEVVKEEF NEHLEVVDKI NQICKNLQFH LNKMRTFEEP
PFEKEANIIV DRWLDINEKT EDYYENLGRA LALWDKLFDL KNGIDEWTEK VLQKLELHQL
TEEEREKLKE ELQVHEQKPS EFSKRVAKIQ FLLQSSEIPL ELQVMESSIL NKIERVKMCL
MGGSHCGAIS GSTAELREDL DQAKTQIGMT ESLLNALSPS DSLEIFTKLE EIQQQILQQK
HSMILLENQI GCLTPELSEL KKQYESVSDL FNTKKSVLQD HFSKLLNDQC KNFNDWFGSI
KMNLKECFEP SETKKCVEQK LQKLSDFLTL EGRGSEIQQV GTVLNHVKKH LPKAPVKKLN
SWIVSQEVEL EKMESICQAR AKELEECLQQ LLRLHNDHRN LSKWLTNQEE IWKEMEGTRE
KTELFCQAVA RKREQFESMA QLNNSVKQYG ITEEEEIVTE STHLIDRYQT LLRQICETDK
EDKLPPAEDQ SFNDLAHDVI HWITGIKESL MVLNSSEGKM PLEERIHKIK EIILLKPEGD
AKIQAIMSQA ESSKTPVVPQ TLTDIKNQWD NTLHLANTYL SHQEKLLLEG EKYLQSKEDL
RLMLTELKKK QEVGFALQPG LQEKKAQLKI YKKFLQKAQD LTFLLEELKS QGNYLLECTK
NPNFSEEPWL EIKHLHESLL QQLQDSVQKL EGHVQEHDSY QLCITDLNTA LDYIAKEFVC
FSDRPVDERV VEEKLQKLQD LENSLHLQDG PLEKILTLAK SVKQNTSSAG QKIIKDDIKS
LKCKQKDLEN RLASAKQEME NCLNSILKSK CSTENKAKFP LPGREEQVTS DVQESTQDSA
AMEKLEEDWE INKNSALEMI LSRQLSLDVQ ESMKNTEDEQ KVNELQNQPL ELDVMLRNEQ
LKEIEELCTQ LEGKKAAIEP LEQSEYLSKT ESSALVLHDE SYSVQHLDNL LQALITLKKK
KESQYCLLED FQGHLMAGES SMKALLTEKE SLKVGLLDST TYMDKIKNFL ASIEKEKDSL
SKMKIEWENL SNCLTDMDKK LLESQIRLLE HGWEQMKQLA QKKYSQQSVG HEEFMFLMSK
IQDLETSLQQ QQQHLQLRLN SPEAQEGNLS VVALATELHT IKHRFSMLKG RAELQMKRIW
GEKERKILED AISNLQKQLE ALEPLNMEVE NQIKKCETRY KIKEAILWVQ NLLGELTPPI
SLLPDDVLSQ IRKCEVVHDG ILAKQQVVES LVEEVKDNIP NFTAYESNDF NNLLQDLQNQ
YQMLALKSTQ RSQQLELKLE ERSKFVAIIG KVQLSLQGNE TLIIPKTDTT STEAELEQLY
VALTTSQKEL QEIKSVISTH LQEQTNISKD LSVFERLFLD DRLKNLKTRA NRTQRFIQNK
CNEVEHKINF YREFHEKISA LQKEFDHIQH NELLLNPEVN PDVKEELYHL KNQITGIQSS
ILQVLKLKEV FDCIELNWDW TQLDQIQTQV LEKERELEEK IKQLNTFVAE YDKYQASLAK
LKALDLQIKK RAEPVLTMPN TPPESSLLNA QVLNQRIGKA MSLYHEIIKK LSENKDFDDL
FKEREIQQLK LYAEEHNKLR QVLQQKMALQ SQLKEMDEKD FKDKLENSLH VLNQIKSQLQ
QPLLINLQIE YIQNEKDNCE VFQEKVQAEM DSIKAVTVIE KQSEENSSEA SVVEAKLNDI
EDLYMQLNAS IDSRTSVLND AYENMTRYNE AVSRAMGIIS DLETIIVSHR VDLDNPKESV
EVPRQKQEEL KSTIAGIQDL TENLGTVSSL EAKRQLECTL QDLVSKNSAL REAAKVKEAE
VERCLDNYKR YRNINEKICT NLSQMETILG QSMCPLPVSY KEALERLEQS KALVSNLMSA
KEELLKQRQV LRHLRAMCTD SDSLCLLRST SALWERWLSL LEAAKEWEMW CEELKQEWKF
VHEEIEREVI ILDNLQEEVP EISKAKEAAS TEELLGLLDC LRQYEENVEQ QQLLLALLLQ
RIKNIQSTPE SLGAVESVPA SQEIMSMQER CHKLLQKAQK NKELMQNEIQ ERHSFTKEIT
TLKNLFQQTT ISFQNMELQD CPEKAEQLEE LQSILKKGKL TFENIMEKLR IKYSEMYTIV
PAEIESQVEE CRNALEDVDE KISNEVLKSS PSYTTSRKID EINNGLRNVE KMLQQKSKNI
EKAQEIQKKM WDELDLWHSK LNELDSEVQD IVEQDPGQAQ EWMDKLMIPF QQYQQVSQRA
ESRTSQLNKA TIKMEEYHDL LKSTEAWIEN TSRLLADPAD YDSSKTLSHH ASTLQMALED
SEQKHTLLHS VFTDLEDLSA IFETDDLAQS IQELSHQVAA LQQRIIESLP QIQRMADDVV
AIETEVKSME KKVSKIKAIL LSKEIFDFSP EEHLKHGEVI LENIRPMKKT IAEIVSYQVE
LRLPQTGMKP LPVFERTNRL LQDIKLLENV TQEQNELLKV TIKQTNECNE EMEKLKQILN
NYPAEFSHEH MSTDQAANLS QVQGEIEGME KQILSLNQKK EDLVVDLKAA ILNLHQHLQQ
KQQELEQEVL SVGASEENTG AEKDASEWKL NRTSSMSFLP ALEEEAEESS LKSESGDKKA
EPSSGFLSLL WKHDKDVEED RASSSSGTII QEAAGKISTC DSSMAQVLEP DLLNTERGPE
FSLSPNQTPE GATPPIKAAA TGLSDEQGAF EATVEKVRPE PAEVLHVCKN QVAELELWLH
QANVAFEPET LDADMQQVVE QQLVGCQAML TEIEQKVASL LENCKDQGLG DSGATQQEAE
ALSLKLKTVK CNLEKVQMML QEKYSEDQHS TTLKKSSEHQ KVLQPDNLSE FESVVTERPQ
FSRQKDFQQQ QVLELKPMEQ KDLIKFIEFN ANKTWPQYCQ HDKDTTQTSS ASSKTSSPQN
DAPDLILSTQ GQSGDKWQYL HHELSSKIRL PLSQLVQPQV TTNMSILPSV TVYNFRYPTT
EELKTYTTQL EDLRQEANNL QAQENTSEET YTNLDKKLFE LFQTLLQCLG SVEDMLQTPG
LFRGDVGTQQ VHYETLALEL KKLYLAMSDK KNDLSKAMTW PGKNASQFLD CFDNLQVYLE
HTQATAASRS KALKAGLDYT HSYQNEIKRL YDQLVKNKTS LQQSLNEISG QTIDEQLQKV
DAYTVELQNS ESRVAKLRDE GERLHLPYVL LQEVYKLEDV LDSMWGLLRA RYTELSCPFI
TESQQDALLQ GMVELVNIGK EKLAHDHLQQ TKSKVALQAQ IQNHKLFFQK LVADMLLIQT
YSNKMLPSLM QKKETFGAEQ VKEVKLLEEK SHQYGIKLQS LLQKWEEFDE NYASLEKDLE
ILMSTLPSVS LVEETEERLV ERISYYQQIK RNLDEKHARL YQTLNEGKQL VASVNCPELE
GQIAKLEEQW LSLNKKIDHE LHRLQTLLKH LLSYNRDSDQ LTKWLESSQQ TLNYWKEQSL
NVSQDLDTIR SNINNFFEFS KEVDEKSSLK TAVLSTGNQL LHLKEADTAT LRASLAQFEQ
KWTGLITQLP DIQEKLHQLQ MEKLPSRKAI MEMIDWMNNV EHQTEDEDSE HSLSSASQVK
NLLQKYKEFR MEMDYKQWIV DFVNQSLLQL STCDVESKRY ERTEFAEHLG EMNRQWQQVH
GALNGKIQHL EQLLESITEN ENKIQILNNW MEAQEERLKT LQKPENVISV QKTLLDCQDI
ENQLAMKSKA LDELRQNYLT SESGTVPLLE DTASKIDELF QKRNNVMNQV NELKTSMQSV
LQEWKIYDKL YDEVNMMTIR FWYCMEHSKP VVLSLEALRC QVQNLQTLQD EAESSEGSWK
KLQEVIGKLK EYCPSVAEII QEKCQNTHTR WTQVNQDIAD QLQRAQSLLQ LWQACSSAHA
EAAARLEPQE TKWQQLANIN TSGNNLAEVL PPALQGAKEL QCEVQKTKEA FLQNSTLLDR
LPQPAEPNTH VLLSSQMHSL QRASYLEKML LVKTNEFEFV LSQFKDFGDR LESLKGLITH
EEENLDKLYR QEKEGNPDLF LNHVLALTAQ SPDIEHLNEV SLKLPLSDVA MKTLQNVNRQ
WIRATATALE RCSELQGIGL NEKFLHCYEK WVQLLQKIEE TLKANMADSL PALLEQQKTY
EMLEAEVSIN QTIADSYVTQ CLQLLDTAEI EKRPEFVWKF TRLKGQWQSA AQGVRQRKSD
IDELVRQWRS FTTSEGDLLR FLADTSHLLS AVKSQDCHSL HQTRSLIHEL KNKEIHFQRW
QTTYALTLEA GEKLLNTANL ETKESVNKRI SQLQDNWKDT KLQLGEMIKR FQSTAETWDQ
CEKKIKELKN RLHVLKAQSK DPLPELHEEL HREKELIKEL EKSLANWTQN LKELHTMKTD
LTQHILVDDV MVLKEQIEHL HRQWEDLCLR VAIRKQEIED RLNSWIVFNE KNKELCAWLV
QMENKVLQTA DISIEEMIEK LQKDCMEEIN LFSENKLQLK QMGDRLIKAS NKTRAAEIDD
KLNKINDRWQ HLFDVIGSRV KKLKETFAFI QQLDKNMSNL RTWLARIESE LSKPVVYDVC
DDQEIQKRLA EQQDLQRDIE QHSAGVESVF NICDVLLHDS DACANETECD SIQQTTRSLD
RRWRNICAMS MERRMKIEET WRLWQKFLDD YSRFEDWLKA AERTAACPNS SEVLYTVAKE
ELKRFEAFQR QIHERLTQLE LINKQYRRLA RENRTDTASK LKQMVHEGNQ RWDNLQKRVT
AILRRLRHFT NQREEFEGTR ESILVWLTEM DLQLTNVEHF SESDADDKMR QLNGFQQEIT
LNTNKIDQLI VFGEQLIQKS EPLDAVLIED ELEELHRYCQ EVFGRVSRFH RRLTSHAPGL
EDEKEASENE TDVEDPREIQ DDSWRKRGAS EEPSSPQSLC QLVPPALGPE RSGCETPVSV
DSIPLEWDHT GDVGGSSSHE EDEEGPYYSA LSDIEILENP EAYLKMTTKT LKASSGKSIS
EGPSWHVPDS PSCPKRRYKQ MGGDRNVQPI PSDSSTPYKP AYVKLLLSPG TEGGKEDPGV
LTGSAQQEDE DLAALTGQQS GAFDRWELIQ AQELHNKLRK KQNLQKLNSD ISNITPWLEK
TGAELETLKL AEPPSDMQEM ELQVKKLKEI LKAFDTYKAL VVSVNVNSKE FLQSESAESK
ELQGRVGQLT LRWNTALGAV ESWREGLRRS LMQCQDFHQL SQSLLLWLAS AESRRQKAHV
TDPEADPQAL LACQEELVQL EKELVERQPQ VNSLQEISST LLIKGHGEDY IEAEEKVHVI
EKKLKQLLEQ VSQDLVSLQR SQNPDSPLPS VDEVDHGEPL AASAPAPQAK FEAEKTTKEK
NKTASRVPGP AAPESSKPQR SFLSRVFRAA LPLQLLLLLL LFLACLLPSS EEDYSCTQAN
NFARSFYPML RYTNGPPPT
//
