ID F1MFG9_BOVIN Unreviewed; 1013 AA.
AC F1MFG9;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Myosin IG {ECO:0000313|Ensembl:ENSBTAP00000008366.4};
GN Name=MYO1G {ECO:0000313|Ensembl:ENSBTAP00000008366.4,
GN ECO:0000313|VGNC:VGNC:31822};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000008366.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000008366.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008366.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000008366.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000008366.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_005192371.1; XM_005192314.3.
DR RefSeq; XP_005205671.1; XM_005205614.3.
DR AlphaFoldDB; F1MFG9; -.
DR SMR; F1MFG9; -.
DR STRING; 9913.ENSBTAP00000008366; -.
DR PaxDb; 9913-ENSBTAP00000008366; -.
DR Ensembl; ENSBTAT00000008366.4; ENSBTAP00000008366.4; ENSBTAG00000006377.4.
DR GeneID; 516513; -.
DR KEGG; bta:516513; -.
DR CTD; 64005; -.
DR VEuPathDB; HostDB:ENSBTAG00000006377; -.
DR VGNC; VGNC:31822; MYO1G.
DR eggNOG; KOG0160; Eukaryota.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000158053; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; F1MFG9; -.
DR OMA; YMILRKY; -.
DR OrthoDB; 1094820at2759; -.
DR TreeFam; TF312960; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000006377; Expressed in blood and 94 other cell types or tissues.
DR ExpressionAtlas; F1MFG9; baseline and differential.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030175; C:filopodium; IEA:Ensembl.
DR GO; GO:0030027; C:lamellipodium; IEA:Ensembl.
DR GO; GO:0031256; C:leading edge membrane; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001891; C:phagocytic cup; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0071976; P:cell gliding; IEA:Ensembl.
DR GO; GO:0031589; P:cell-substrate adhesion; IEA:Ensembl.
DR GO; GO:0006887; P:exocytosis; IEA:Ensembl.
DR GO; GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; IEA:Ensembl.
DR GO; GO:0120117; P:T cell meandering migration; IEA:Ensembl.
DR GO; GO:0002456; P:T cell mediated immunity; IEA:Ensembl.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF381; UNCONVENTIONAL MYOSIN-IG; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 9..702
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 819..1012
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 579..601
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 102..109
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1013 AA; 115907 MW; 742624AC49A0A3BC CRC64;
MEDDEGPECG KPDFVLLDQV TMEDFMENLK LRFEKGRIYT YIGEVLVSVN PYQELPLYGP
EAIARYQGRE LYERPPHLYA VANAAYRAMK RRSRDTCIVI SGESGAGKTE ASKHIMQYIA
AVTNPSQRAE VERVKDVLLK STCVLEAFGN ARTNRNHNSS RFGKYMDINF DFKGDPVGGH
IHSYLLEKSR VLKQHVGERN FHAFYQVLRG CEDEELQELH LQRNPAVYNF TRQGAGLNVL
DIDEKSHHQA VTEAMRVIGF SPEEVASVHR ILAAILHLGN IEFVELESNL EQGRLAVTEE
VLVDHVAELT ATPRELVLRC LLARTVASGG REVIEKGHTA AEASYARDAC AKAVYQRLFE
WVVDRINHVM EPRDRDPRRD GKDTVIGVLD IYGFEVFPVN SFEQFCINYC NEKLQQLFIQ
LILKQEQEEY EREGIAWQTV EYFNNATIVD LVERPHRGIL SVLDEACSTA GPITDRIFLQ
TLDTHHRHHP HYTSRQLCPT DKTMEFGRDF RIKHYAGDVT YSVEGFIDKN RDFLFQDFKR
LLYNSKDPTL RAMWPDGQQD ITEVTKRPLT AGTLFKNSMV ALVENLASKE PFYVRCIKPN
EDKVAGKLDE GHCRHQVAYL GLLENVRVRR AGFASRQPYA RFLLRYKMTC EYTWPNHLLG
SDKAAVGALL EQHGLQGDVA FGHSKLFIRS PRTLVTLEQS RACLIPIIVL LLQKAWRGTL
ARRRCRRLRA IYTIMRCFRR HKVRAHLTEL QRRFQAARQP PHYGRDLVWP PPPTVLQPFQ
DICQALFSRW RARQLVKNIP PSDMAQIKAK VAAMAALQEL RQDWGCRRAW ARDYLSSATD
NPTASGLFAQ RLKTLREKDG FGAVLFSSHV RKVNRFNKSR DRALLLTDRH LYKLEPGRQY
RVMRAVPLDA VTGLSVTSGR DQLVVLHARG YDDLVVCLHR SQPPLDNRIG ELVGVLAAHC
QGEGRALEVR VSDCIPLTQR GARRLVSVEP RSEQPEPDFR CSRGAFTLLW PSC
//
