ID   F1MFZ8_BOVIN            Unreviewed;       578 AA.
AC   F1MFZ8;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 3.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=Steroid sulfatase {ECO:0000313|Ensembl:ENSBTAP00000027703.5};
GN   Name=STS {ECO:0000313|Ensembl:ENSBTAP00000027703.5,
GN   ECO:0000313|VGNC:VGNC:49976};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000027703.5, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000027703.5, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027703.5,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000027703.5}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027703.5};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   AlphaFoldDB; F1MFZ8; -.
DR   Ensembl; ENSBTAT00000027703.5; ENSBTAP00000027703.5; ENSBTAG00000020789.5.
DR   VEuPathDB; HostDB:ENSBTAG00000020789; -.
DR   VGNC; VGNC:49976; STS.
DR   eggNOG; KOG3867; Eukaryota.
DR   GeneTree; ENSGT00940000161153; -.
DR   HOGENOM; CLU_006332_13_4_1; -.
DR   TreeFam; TF314186; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000020789; Expressed in ascending colon and 59 other cell types or tissues.
DR   ExpressionAtlas; F1MFZ8; baseline.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16159; ES; 1.
DR   Gene3D; 3.30.1120.10; -; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   Gene3D; 1.10.287.550; Helix hairpin bin; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR42693; ARYLSULFATASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR42693:SF9; STERYL-SULFATASE; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   Pfam; PF14707; Sulfatase_C; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..578
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030168667"
FT   TRANSMEM        175..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          22..407
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   578 AA;  64458 MW;  6182194373781A16 CRC64;
     MMTLLLLLLF LCETQSWAAS KPNFVLLMAD DLGIGDPGCY GNKTLRTPNI DRLARGGVKL
     TQHLAASPLC TPSRAAFMTG RYPVRSGMAS QSQVGVFLFS ASSGGLPPSE ITFAKLLKDQ
     GYSTALIGKW HLGISCHDPG DFCHHPTSHG FDYFHGLPLT NMRDCKLGEG SVFTAAFRLL
     VLLPMQLIAL ALLTLVVLKW LGLFRAPPCA FLFLFLLATL LLGLLLGFLH YFRPLNCFLM
     RNRDITQQPM SYDNLTQRLT ADAAHFLRRN AETPFLLVLS FLHMHTALFS SKDFAGKSQH
     GSYGDAAEEM DWSVGQILDV LHELKLANNT LVYFSSDQGA HVEEVTVKGE VQGGSNGIYK
     GGKANNWEGG IRVPGIVRWP GVIQAGLEID EPTSNMDIFP TVAKLAGSPL PQDRVIDGRD
     LMPLLQMRTQ RSEHEFLFHY CNSYLNAVRW HPPNSTSIWK AFFFTPKFSP EGANGCFDTH
     VCFCYGQYVT YHDPPLLFEI SRDPRERNPL TPTSEPRFWE ILEAMQEAAA RHARTLQDVP
     NQLSLGNLMW KPWLQLCCSS LGLSCQCDRE DQDGRHSP
//