ID F1MH42_BOVIN Unreviewed; 911 AA.
AC F1MH42;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Inositol 1,4,5-triphosphate receptor associated 1 {ECO:0000313|Ensembl:ENSBTAP00000043465.3};
GN Name=IRAG1 {ECO:0000313|Ensembl:ENSBTAP00000043465.3,
GN ECO:0000313|VGNC:VGNC:112644};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000043465.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000043465.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000043465.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000043465.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000043465.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_776817.2; NM_174392.3.
DR AlphaFoldDB; F1MH42; -.
DR SMR; F1MH42; -.
DR Ensembl; ENSBTAT00000046140.4; ENSBTAP00000043465.3; ENSBTAG00000007129.6.
DR GeneID; 281918; -.
DR KEGG; bta:281918; -.
DR CTD; 10335; -.
DR VEuPathDB; HostDB:ENSBTAG00000007129; -.
DR VGNC; VGNC:112644; IRAG1.
DR GeneTree; ENSGT00530000063722; -.
DR InParanoid; F1MH42; -.
DR OMA; MGVDLTC; -.
DR TreeFam; TF331789; -.
DR Reactome; R-BTA-418457; cGMP effects.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000007129; Expressed in myometrium and 100 other cell types or tissues.
DR ExpressionAtlas; F1MH42; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0019934; P:cGMP-mediated signaling; IBA:GO_Central.
DR InterPro; IPR008677; MRVI1.
DR PANTHER; PTHR15352:SF2; INOSITOL 1,4,5-TRIPHOSPHATE RECEPTOR ASSOCIATED 1; 1.
DR PANTHER; PTHR15352; LYMPHOID-RESTRICTED MEMBRANE PROTEIN, JAW1; 1.
DR Pfam; PF05781; MRVI1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 853..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 174..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 547..574
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 72..92
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..823
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 911 AA; 98356 MW; 351B061D69F3232A CRC64;
MVKAPQSEER LAGGGKGNNS VLACGAQASW SIFGADAAEV PGTRSHSRQE AAMPHIPEDE
EPPGEPQAAQ SPAGQDPATT GISCSPPTII LTGDASSPEG ETDKNPVNRA HSPHRRLSHR
HLKVSTASLT SVDPAGHVID LVNDQLPDIS ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK
SRSSPGESSP AVSPNLSPGA SPASSQSNSL TVPTPPGLDV CSGPPSPLPG APPQKGDEAE
VPSPHLGESN VLKGLADRKQ NDQRTLSQGR LTARSPTVEK SKEITIEHKE NFDPLQRPEA
IPKGPASGPG SGGKMALNSP QPGPVESELG KPLAKTAKEG NPLPRGPTQG SGGVAPQASQ
GKSTVGEPAG SKVGSKAELW PPTSRPPLLR GVSWDSGPEE PGPRLQKVLA KLPLAEEEKR
FTGKAGSKLA KAPGLKDFQI QVQPVRMQKL TKLREEHILL RNQNLVGLKL PELSEAAEQE
KGHPSELSSA IEEEESKGGL DVMPNISDVL LRKLRVHKSL PGSAPPLTEK EVENVFVQLS
LAFRNDSYTL ESRINQAERE RNLTEENTEK ELENFKASIT SSASLWHHCE HRETYQKLLE
DIAVLHRLAA RLSSRAEMVG AVRQEKRMSK ATEVMMQYVE NLKRTYEKDH AELMEFKKLA
NQNSSRSCGP SEDGVPRTAR SMSLSLGKNM PRRRVSVAVV PKFNILNLPG QSPSSSPIPS
LPALSESSNG KGNPPVSSAL PALLENGKTN GDPDCEASAS VPTPSCLEGI SQEAKARMEE
EAYNKGYQEG LKKTKELQGL REEEEEQKSE SPEEPEEAAE TEEEEKEQRS SKLEELVHFL
QVMYPKLCQH WQVIWMMAAA MLVLTVVLGL YGSHNSCVEQ ADGSLGKSTC SAAQRDSWWS
SGLQHEQPTE Q
//
