ID F1MHP0_BOVIN Unreviewed; 2022 AA.
AC F1MHP0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN5A {ECO:0000313|Ensembl:ENSBTAP00000012068.6,
GN ECO:0000313|VGNC:VGNC:34352};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000012068.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000012068.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012068.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000012068.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000012068.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 9913.ENSBTAP00000012068; -.
DR PaxDb; 9913-ENSBTAP00000012068; -.
DR Ensembl; ENSBTAT00000012068.6; ENSBTAP00000012068.6; ENSBTAG00000009155.6.
DR VEuPathDB; HostDB:ENSBTAG00000009155; -.
DR VGNC; VGNC:34352; SCN5A.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000161691; -.
DR HOGENOM; CLU_000540_5_0_1; -.
DR InParanoid; F1MHP0; -.
DR OMA; FTEMEQD; -.
DR TreeFam; TF323985; -.
DR Reactome; R-BTA-5576892; Phase 0 - rapid depolarisation.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000009155; Expressed in cardiac atrium and 33 other cell types or tissues.
DR ExpressionAtlas; F1MHP0; baseline.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0017134; F:fibroblast growth factor binding; IEA:Ensembl.
DR GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0050998; F:nitric-oxide synthase binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0086060; F:voltage-gated sodium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR GO; GO:0086061; F:voltage-gated sodium channel activity involved in bundle of His cell action potential; IEA:Ensembl.
DR GO; GO:0086062; F:voltage-gated sodium channel activity involved in Purkinje myocyte action potential; IEA:Ensembl.
DR GO; GO:0086063; F:voltage-gated sodium channel activity involved in SA node cell action potential; IEA:Ensembl.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
DR GO; GO:0098912; P:membrane depolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; IEA:Ensembl.
DR GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR GO; GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:1902305; P:regulation of sodium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008053; Na_channel_a5su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF206; SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01666; NACHANNEL5.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 230..247
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 391..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 721..739
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 751..772
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 784..801
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 841..864
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 884..901
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 921..944
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1210..1229
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1250..1266
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1278..1299
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1327..1353
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1449..1475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1534..1552
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1564..1586
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1598..1614
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1651..1679
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1754..1777
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 135..425
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 512..670
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 721..950
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 958..1205
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1209..1484
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1533..1787
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 27..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..2022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 416..450
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 483..506
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1059..1073
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1964..2000
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2022 AA; 228168 MW; 8B406A5C7CF7826F CRC64;
MAAFLLPRGT SSFRRFTRES LAAIEKRMAE KQARSSAASQ ESRDGLPEEE APRPQLDLQA
SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LHVLSPFHPI
RRVAVKILVH SYPFMLIMCT ILTNCVFMAQ HDPPPWTKYV EYIFTAIYTF ESLVKILARG
FCLHAFTFLR DPWNWLDFSV IIMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV
GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTVLNGT NSTNASVEAD
GLIWASLDDY LNDPENYLLK NGTSDVLLCG NSSDAGTCPE GYRCLKAGEN PDHGYTSFDS
FAWAFLALFR LMTQDCWERL YQQTLRSAGK IYMIFFMLVI FLGSFYLVNL ILAVVAMAYE
EQNQATIAET EEKEKRFQEA MELLKKEQEA LAIRGVDTVS RSSLEMSPLA PVTTHERRSK
RRKRMSSGME ECGDDKFPKS DSEDGPRAVN RFSITHGLSR TSMKPRSSHG SIFTFRRRDL
GSETDFADDE NSTAGDSESH RTSLLVPWPL RRPSTLGQPS PGTSTPGHVL NGKRNSTVDC
NGVVSLLGAG DPEATSPGSH LLHPMKLERP PDTTTPSEEP GRPQTLTPQA PCVDGFEEPG
ERQRALSAVS VLTSALEELE ESQRRCPPCW IRFAQHYLIW ECCPLWMSIK QKVKFMVMDP
FADLTITMCI VLNTLFMALE HYNMTTEFEE MLQVGNLVFT GIFTAEMTFK IIALDPYYYF
QQGWNIFDSI IVILSLMELG LSRMGNLSVL RSFRLLRVFK LAKSWPTLNT LIKIIGNSVG
ALGNLTLVLA IIVFIFAVVG MQLFGKNYSE QRHRISDSGL LPRWHMMDFF HAFLIIFRIL
CGEWIETMWD CMEVSGQSLC LLVFLLVMVI GNLVVLNLFL ALLLSSFSAD NLTAPDEDGE
MNNLQLALAR IQRGLRFIKR TTWDFCCVLL QRPPQKPTAL ASQGQLPGCI ATSSPPPQPE
SEKAPPARKE TRFEEGQRPG QGAPGDAEPV CVPIAMAESD TDDPEEDEEN SLSTEEESSK
QQESQPASGS PEALPEPRVW SQVSETTSSG AEASEVQADL RQQRRAEAPA PGCSELPEDS
YSEGSTADMT NTADLLEQIP DLGEDVKDPE DCFTEGCVRR CPCCTVDTTQ AHGKVWWRLR
KTCYRIVEHS WFETFIIFMI LLSSGALAFE DIYLEERKTI KVLLEYADKM FTYVFVLEML
LKWVAYGFKK YFTNAWCWLD FLIVDVSLIS LVANALGFAE MGPIKSLRTL RALRPLRALS
RFEGMRVVVN ALVGAIPSIM NVLLVCLIFW LIFSIMGVNL FAGKFGRCIN QTEGDLPLNY
TIVNNKSDCE SFNVTGELYW TKVKVNFDNV GAGYLALLQV ATFKGWMDIM YAAVDSRGYE
EQPQWEYNLY MYIYFVIFII FGSFFTLNLF IGVIIDNFNQ QKKKIRGQDI FMTEEQKKYY
NAMKKLGSKK PQKPIPRPLN KYQGFIFDIV TKQAFDVTIM FLICLNMVTM MVETDDQSPE
KVNILAKINL LFVGIFTAEC IFKMVALRHY YFTNSWNIFD FVVVILSIVG TVLSDIIQKY
FFSPTLFRVI RLARIGRILR LIRGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYSIFG
MANFAYVKWE AGIDDMFNFQ TFANSMLCLF QITTSAGWDG LLSPILNTGP PYCDPNLPNS
NGSRGNCGSP AVGILFFTTY IIISFLIVVN MYIAIILENF SVATEESTEP LSEDDFDMFY
EIWEKFDPEA TQFIEYLALS DFADALSEPL RIPKPNQISL INMDLPMVSG DRIHCMDILF
AFTKRVLGES GEMDALKIQM EEKFMAANPS KISYEPITTT LRRKHEEVSA TIIQRAFRRH
LLQRSVKHAS FLYRQQAGSS GLSEEDAPEQ EGLIAYMMNE NFSRRPGPPS SSSVSSTSFP
PSYDSVTRAT SDNPQVRASD YSPSEDLADF PPTPDRDRES IV
//
