ID F1MJR2_BOVIN Unreviewed; 1740 AA.
AC F1MJR2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRD {ECO:0000313|Ensembl:ENSBTAP00000013433.6,
GN ECO:0000313|VGNC:VGNC:33548};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000013433.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000013433.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013433.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000013433.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000013433.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR Ensembl; ENSBTAT00000013433.6; ENSBTAP00000013433.6; ENSBTAG00000010178.6.
DR VEuPathDB; HostDB:ENSBTAG00000010178; -.
DR VGNC; VGNC:33548; PTPRD.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000153617; -.
DR HOGENOM; CLU_001645_4_2_1; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000010178; Expressed in prefrontal cortex and 85 other cell types or tissues.
DR ExpressionAtlas; F1MJR2; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 8.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14628; R-PTP-D-2; 1.
DR CDD; cd14624; R-PTPc-D-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045905; R-PTP-delta_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1095..1118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..146
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 153..243
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 248..344
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 346..435
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 440..537
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 542..650
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 651..744
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 749..844
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1185..1440
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1360..1431
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1472..1731
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1649..1722
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 432..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1740 AA; 195448 MW; 2BE1A05566EFA873 CRC64;
MLLLSNLICI HIIHPGGTPI RGALQIEQSE ESDQGKYECV ATNSAGTRYS APANLYVRVR
RVPPRFSIPP TNHEIMPGGS VNITCVAVGS PMPYVKWMLG AEDLTPEDDM PIGRNVLELN
DVRQSANYTC VAMSTLGVIE AIAQITVKAL PKPPGTPVVT ESTATSITLT WDSGNPEPVS
YYIIQHKPKN SEEPYKEIDG VATTRYSVAG LSPYSDYEFR VVAVNNIGRG PPSEPVLTQT
SEQAPSSAPR DVQARMLSST TILVQWKEPE EPNGQIQGYR VYYTMDPTQH VNNWMKHNVA
DSQITTIGNL VPQKTYSVKV LAFTSIGDGP LSSDIQVITQ TGVPGQPLNF KAEPESETSI
LLSWTPPRSD TIASYELVYK DGEHGEEQRI TIEPGTSYRL QGLRPNSLYY FRLAARSPQG
LGASTAEISA RTMQSKPSAP PQDISCTSPS STSILVSWQP PPVDKQNGII TEYSIKYTAV
DGEDDKPHEI LGIPSDTTKY LLEQLEKWTE YRITVTAHTD VGPGPESLSV LIRTDEDVPS
GPPRKVEVEA VNSTSVKVSW RSPVPNKQHG QIRGYQVHYV RMENGEPRGQ PMLKDVMLAD
AQWEFDDTTE HDMIISGLQP ETSYSLTVTA YTTKGDGARS KPKLVSTTGA VPGRPRLVIN
HTQMNTALIQ WHPPVDTFGP LQGYRLKFGR KDVEPLTTLE FSEKEDHFTA TDIHKGASYI
FRLSARNKVG FGEEMVKEIS VPEEVPTGFP QNLQSEGTTS TSTQLSWQPP VLAERNGIIT
KYTLLYRDIN IPLLPVEQLI VPADTTLTLS GLKPDTTYDV KVRAHTSKGP GPYSPSVQFR
TLPVNQVFAK NFHVKAVMKT SVLLSWEIPE NYNSAMPFKI LYDDGKMVEE VDGRATQKLI
VNLKPEKSYS FVLTNRGNSA GGLQHRVTAK TAPDVLRTKP AFIGKTNLDG MITVQLPEVP
ANENIKGYYI IIVPLKKSRG KFIKPWESPD EMELDELLKE ISRKRRSLRH GREVELKPYI
AAHFDVLPTE FTLGDDKHYG GFTNKQLQSG QEYVFFVLAV MEHAESKMYA TSPYSDPVVS
MDLDPQPITD EEEGLIWVVG PVLAVVFIIC IVIAILLYKR KRAESDSRKS SIPNSKEVPS
HHPTDPVELR RLNFQTPGMA SHPPIPILEL ADHIERLKAN DNLKFSQEYE SIDPGQQFTW
EHSNLEVNKP KNRYANVIAY DHSRVLLSAI EGIPGSDYVN ANYIDGYRKQ NAYIATQGSL
PETFGDFWRM IWEQRSATVV MMTKLEERSR VKCDQYWPSR GTETHGLVQV TLLDTVELAT
YCVRTFALYK NGSSEKREVR QFQFTAWPDH GVPEHPTPFL AFLRRVKTCN PPDAGPMVVH
CSAGVGRTGC FIVIDAMLER IKHEKTVDIY GHVTLMRAQR NYMVQTEDQY IFIHDALLEA
VTCGNTEVPA RNLYAYIQKL TQIETGENVT GMELEFKRLA SSKAHTSRFI SANLPCNKFK
NRLVNIMPYE STRVCLQPIR GVEGSDYINA SFIDGYRQQK AYIATQGPLA ETTEDFWRML
WEHNSTIVVM LTKLREMGRE KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA
RDGQSRTVRQ FQFTDWPEQG VPKSGEGFID FIGQVHKTKE QFGQDGPISV HCSAGVGRTG
VFITLSIVLE RMRYEGVVDI FQTVKMLRTQ RPAMVQTEDQ YQFCYRAALE YLGSFDHYAT
//
