ID F1MKL3_BOVIN Unreviewed; 996 AA.
AC F1MKL3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=NLR family pyrin domain containing 9 {ECO:0000313|Ensembl:ENSBTAP00000006201.4};
GN Name=NLRP9 {ECO:0000313|Ensembl:ENSBTAP00000006201.4,
GN ECO:0000313|VGNC:VGNC:32121};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000006201.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000006201.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006201.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000006201.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006201.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR RefSeq; XP_010813782.1; XM_010815480.1.
DR AlphaFoldDB; F1MKL3; -.
DR Ensembl; ENSBTAT00000006201.5; ENSBTAP00000006201.4; ENSBTAG00000004725.5.
DR VEuPathDB; HostDB:ENSBTAG00000004725; -.
DR VGNC; VGNC:32121; NLRP9.
DR GeneTree; ENSGT00940000163218; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; F1MKL3; -.
DR OMA; PWIDEEY; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000004725; Expressed in oocyte and 2 other cell types or tissues.
DR GO; GO:0061702; C:canonical inflammasome complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0050727; P:regulation of inflammatory response; IBA:GO_Central.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF13; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 9; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 9.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 1..94
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 150..348
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 996 AA; 114236 MW; CE6EB4A719602DD6 CRC64;
MAESFFSDFG LLWYLEELKK EEFWKFKELL KQEPLKLKLK PIPWTELKKA SRENVSKLLS
KHYPGKLAWD VTLNLFLQIS RDDLWRKARN EIRQKINPYR SHMKQKFQVL WEKEPCLLVP
EDFYEETTKI EYELLSTVYL DAFKPGESSP TVVLHGPEGI GKTTFLRKVM LEWAKGNLWR
DRFSFVFFLT GREMNGVTDM SLVELLSRDW PESSEPIEDI FSQPERILFI LDGMEELKFD
LDCNADLCED WEQPQSMQVV LQSLLQKQML PECSLLLALS KMGMRKNYSL LKHMKCIFLL
GFSEHQRKLY FSHYFQEKDA SSRAFSFVRE KSSLFVLCQS PFLCWLVCTS LKCQLEKGED
LELDSETITG LYVSFFTKVF RSGSETCPLK QRRARLKSLC TLAAEGMWTC TFLFCPEDLR
RNGVSESDTS MWLDMKLLHR SGDCLAFIHT CIQEFCAAMF YMFTRPKDPP HSVIGNVTQL
ITRAVSEHYS RLSWTAVFLF VFSTERMTHR LETSFGFPLS KEIKQEITQS LDTLSQCDPN
NVMMSFQALF NCLFETQDPE FVAQVVNFFK DIDIYIGTKE ELIICAACLR HCHSLQKFHL
CMEHVFPDES GCISNTIEKL TLWRDVCSAF TASEDFEILN LDNCRFDEPS LAVLCRTLSQ
PVCKLRKFVC NFASNLANSL ELFKVILHNP HLKHLNFYGS SLSHMDARQL CEALKHPMCN
IEELMLGKCD ITGEACEDIA SVLVHNKKLN LLSLCDNALK DDGVLVLCEA LKNPDCALEA
LLLSHCCFSS AACDHLSQVL LYNRSLTFLD LGSNVLKDEG VTTLCESLKH PSCNLQELWL
MNCYFTSVCC VDIATVLIHS EKLKTLKLGN NKIYDAGAKQ LCKALKHPKC KLENLGLEAC
ELSPASCEDL ASALTTCKSL TCVNLEWITL DYDGAAVLCE ALVSLECSLQ LLGLNISSYD
EEIKMMLTQV EEMNPNLIIS HHLWTDDEGR RRGILV
//
