ID F1MLK4_BOVIN Unreviewed; 1072 AA.
AC F1MLK4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=MLLT10 histone lysine methyltransferase DOT1L cofactor {ECO:0000313|Ensembl:ENSBTAP00000053600.3};
GN Name=MLLT10 {ECO:0000313|Ensembl:ENSBTAP00000053600.3,
GN ECO:0000313|VGNC:VGNC:58389};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053600.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000053600.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053600.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000053600.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053600.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1MLK4; -.
DR SMR; F1MLK4; -.
DR STRING; 9913.ENSBTAP00000053600; -.
DR Ensembl; ENSBTAT00000061645.3; ENSBTAP00000053600.3; ENSBTAG00000044074.3.
DR VEuPathDB; HostDB:ENSBTAG00000044074; -.
DR VGNC; VGNC:58389; MLLT10.
DR eggNOG; KOG0956; Eukaryota.
DR GeneTree; ENSGT00940000157711; -.
DR HOGENOM; CLU_010286_0_1_1; -.
DR InParanoid; F1MLK4; -.
DR OMA; XFSELLN; -.
DR TreeFam; TF316118; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000044074; Expressed in spermatocyte and 108 other cell types or tissues.
DR ExpressionAtlas; F1MLK4; baseline.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd20901; CC_AF10; 1.
DR CDD; cd15708; ePHD_AF10; 1.
DR CDD; cd15574; PHD_AF10_AF17; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR049773; AF10-like_CC.
DR InterPro; IPR049781; AF10/AF17_PHD.
DR InterPro; IPR049775; AF10_ePHD.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF93; PROTEIN AF-10; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 22..74
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 79..198
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 134..197
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 206..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 741..778
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 338..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1072 AA; 113646 MW; BC3DF7AEEC350512 CRC64;
MVSSDRPVSL EDEVSHSMKE MIGGCCVCSD ERGWAENPLV YCDGHGCSVA VHQACYGIVQ
VPTGPWFCRK CESQERAARV RCELCPHKDG ALKRTDNGGW AHVVCALYIP EVQFANVSTM
EPIVLQSVPH DRYNKTCYIC DEQGRESKAA TGACMTCNKH GCRQAFHVTC AQFAGLLCEE
EGNGADNVQY CGYCKYHFSK LKKSKRGSNR SYDQSLSDSS SHSQDKHHEK EKKKYKEKDK
HKQKHKKQPE PSPALVPSLT VTTEKTYTST SSNSISGSLK RLEDTAARFT NANFQEVSAH
TTSAKDVSEA RGSEGKGKKS SAHSSGQRGR KPGGRNPGTT VSAASPFQQG SFSGTPGSVK
SSSGSSVQSP QDFLSFTDSD LRNDSYTHSQ QSSSTKDVHK GESGSQEGGV NSFSSIIGLP
SASAVISQPK SFENSPGDLG NSSLPTAGYK RAQTSGIEEE TVKEKKRKGN KQSKHGPGRP
KGNKNQENVS HLSVSSASPT SSVASAAGSV TSSSLQKSPT PLRNGSVQSL SVGSSPLGSE
ISMQYRHDGA CPTTTFSELL NAIHNGIYNS NDVAVSFPNV VSGSGSSTPV SSSHLPQQPS
GHLQQVGALS PSAGSSAPSA VAATQANTLS GSSLNQASSH MYGNRLNSTS SMAALIAQSE
NNQTDQDLGD NSRSLAGRGS SPRGSLSPRS PVSNLQIRYD QPGNSSLENL PPVAASIEQL
LERQWSEGQQ FLLEQGTPSD ILGMLKSLHQ LQVENRRLEE QIKNLTAKKE RLQLLNAQLS
VPFPTITANP SPSHQMHAFP AQNAPTTDSL NSSKSPHLGN SFLPDNSLPV LNQDLTSSGQ
STSSSSALST PPPAGQSPAQ QGSGVSGVQQ VNGVTVGALA SGMPTVTSTI PAVPGVGGII
GALPGNQLAI NGIVGALNGV IQTPVTISQN PTPLTHTTVP PNATHPMPAT LTNSASGLGL
LSDQQRQIFL HQQQFQQLLN SQQLTPEQHQ ALLYQLVQQH HQQQQQHHQP DLQQLQIPGP
TQIPINNLLA GTQAPPLHPA TTNPFLTIHG DNASQKVTRL SDKSGPVAQE KS
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