ID F1MM13_BOVIN Unreviewed; 804 AA.
AC F1MM13;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase {ECO:0000313|Ensembl:ENSBTAP00000053207.3};
GN Name=H6PD {ECO:0000313|Ensembl:ENSBTAP00000053207.3};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000053207.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000053207.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053207.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000053207.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000053207.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC {ECO:0000256|ARBA:ARBA00004959}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1MM13; -.
DR SMR; F1MM13; -.
DR STRING; 9913.ENSBTAP00000053207; -.
DR PaxDb; 9913-ENSBTAP00000053207; -.
DR Ensembl; ENSBTAT00000061269.3; ENSBTAP00000053207.3; ENSBTAG00000004246.7.
DR VEuPathDB; HostDB:ENSBTAG00000004246; -.
DR eggNOG; KOG0563; Eukaryota.
DR eggNOG; KOG3147; Eukaryota.
DR GeneTree; ENSGT00530000063435; -.
DR HOGENOM; CLU_018975_0_0_1; -.
DR InParanoid; F1MM13; -.
DR OMA; YCPQSGT; -.
DR OrthoDB; 989808at2759; -.
DR TreeFam; TF354247; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000004246; Expressed in liver and 108 other cell types or tissues.
DR ExpressionAtlas; F1MM13; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:InterPro.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IBA:GO_Central.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR CDD; cd01400; 6PGL; 1.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR019796; G6P_DH_AS.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01198; pgl; 1.
DR PANTHER; PTHR23429:SF7; GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE 1: Evidence at protein level;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1MM13};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..804
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018659969"
FT DOMAIN 41..223
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 230..520
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT DOMAIN 573..795
FT /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT /evidence="ECO:0000259|Pfam:PF01182"
FT BINDING 220
FT /ligand="substrate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10005"
SQ SEQUENCE 804 AA; 90420 MW; C351AC2CE2A5F4F6 CRC64;
MLAEPHFKRR PCVWKMLMAA MCVALLSGLQ AQDLPRQVSI ILLGATGDLA RKYLWQGLFH
LYLEEVGKGH HFRFHGTALT STEQGQEVIA KVLESLSCPG DMASGHCAEL KAQFQQLSEY
RQLKTPEDYV ALSKDIEAQV EHEGLRETGR IFYLSVPPFA YVDIARNINS SCRPGPGAWL
RVVLEKPFGH DLHSAQQLAT ELGSFFQEEE MYRVDHYLGK QVVAQILPFR DQNRAALDGL
WNRHHVERVE IVMKETLDAE GRTSFYEEYG VIRDVLQNHL TEVLTLVAME LPVNVSSPES
VLQHKLQAFQ ALRSLQRHSA VLGQYQAYSG QVRRELQKPD SFHSLTPTFA GILVHIDNLR
WEGVPFILMS GKALDERVSY VRILFKNQAF CVQSEKHWVA AQSHCLPRQI IFYIGHGELG
SPAVLVSRNL FQPALPSASW KEVEGRPGLH LFGLPLSDYY AYSPVREQDA YSLLISHIFH
CRKDSFVTTE NLLASWVFWT PLLDSLAHEV PRFYPGGAEN GQLLDFEFSG GHLSFSQPLP
EQLVPGPDSA PLPSDFQVLR AKYRESPLIS AWPEELIARL AGDIEAAAVR AVRRFGKFHL
ALSGGSSPVA LFQQLATGHY SFPWAHTHLW LVDERCVPLW DPESNFQGLQ THLLQHVRVP
HYNVHPMPVH RRQRLCAEED QGAQAYAEEI SALVTNGSFD LVLLGMGTDG HTASLFPQSP
AGLDGEQLVV LTTSPSSPHR RMSLSLPLIN RARKVAVLVM GRMKREIAML VSRVGRDPKK
WPISGVLPDS GQLVWYMDYD AFLG
//