ID F1MMH1_BOVIN Unreviewed; 431 AA.
AC F1MMH1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Regulator of G protein signaling 11 {ECO:0000313|Ensembl:ENSBTAP00000022048.5};
GN Name=RGS11 {ECO:0000313|Ensembl:ENSBTAP00000022048.5,
GN ECO:0000313|VGNC:VGNC:33912};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000022048.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000022048.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022048.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000022048.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022048.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1MMH1; -.
DR SMR; F1MMH1; -.
DR STRING; 9913.ENSBTAP00000022048; -.
DR PaxDb; 9913-ENSBTAP00000022048; -.
DR Ensembl; ENSBTAT00000022048.5; ENSBTAP00000022048.5; ENSBTAG00000016574.5.
DR VEuPathDB; HostDB:ENSBTAG00000016574; -.
DR VGNC; VGNC:33912; RGS11.
DR eggNOG; KOG3589; Eukaryota.
DR GeneTree; ENSGT00940000160198; -.
DR HOGENOM; CLU_025092_0_0_1; -.
DR InParanoid; F1MMH1; -.
DR OMA; EFYKQEM; -.
DR TreeFam; TF351956; -.
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Reactome; R-BTA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000016574; Expressed in retina and 75 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF3; REGULATOR OF G-PROTEIN SIGNALING 11; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 32..107
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 301..399
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 431 AA; 49101 MW; 5FD861047B5B9F17 CRC64;
MAASPAPLGG HPRVQRPHLS KMERMVVTMQ DPDQGVRMRS QRLLVTVIPH AVNGSDIVEW
LMQKYSIAED EALHLGSLLV QHGYLYPLRD PRRLELRPDE TPYRFQTPYF WTSTLWPAAE
LDYAIYLAKK NIRKQGALVD HEKEHYQQLH RKINHAWDLV MMQAREQLRA AKQRRKGDRL
VIACQEQTYW LVNRPPPGAP SVLEQGPGRG PCTAGRVPMT LDFYRREVEC LRRALGRARV
KSSTCLEAYL KFSSQHGPHD PIMSGCLPSN PWVTDDDAYW AMNAPSAAVP TRLRVEQWAF
SFRELLEDPV GRAHFMDFLG KEFSAENLSF WEACEELRHG GQAQVPALVD AVYQQFLAPG
AARWVNIDSR TMEQTLAGLT QPHRHVLDDA QRHIYLLMKK VGVPTPLGAG VRLQPRPVQT
HRPSCPLPSL T
//
