ID F1MMI4_BOVIN Unreviewed; 420 AA.
AC F1MMI4;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Protein maelstrom homolog {ECO:0000256|ARBA:ARBA00021076};
GN Name=MAEL {ECO:0000313|Ensembl:ENSBTAP00000034004.2,
GN ECO:0000313|VGNC:VGNC:31136};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000034004.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000034004.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000034004.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000034004.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000034004.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a central role during spermatogenesis by repressing
CC transposable elements and preventing their mobilization, which is
CC essential for the germline integrity. Acts via the piRNA metabolic
CC process, which mediates the repression of transposable elements during
CC meiosis by forming complexes composed of piRNAs and Piwi proteins and
CC governs the methylation and subsequent repression of transposons. Its
CC association with piP-bodies suggests a participation in the secondary
CC piRNAs metabolic process. Required for the localization of germ-cell
CC factors to the meiotic nuage. {ECO:0000256|ARBA:ARBA00025698}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the maelstrom family.
CC {ECO:0000256|ARBA:ARBA00007057}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1MMI4; -.
DR SMR; F1MMI4; -.
DR Ensembl; ENSBTAT00000034103.3; ENSBTAP00000034004.2; ENSBTAG00000016550.6.
DR VEuPathDB; HostDB:ENSBTAG00000016550; -.
DR VGNC; VGNC:31136; MAEL.
DR GeneTree; ENSGT00390000003645; -.
DR HOGENOM; CLU_051692_0_0_1; -.
DR InParanoid; F1MMI4; -.
DR OMA; GARNAYY; -.
DR TreeFam; TF323573; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000016550; Expressed in oocyte and 55 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043186; C:P granule; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007140; P:male meiotic nuclear division; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0034587; P:piRNA processing; IBA:GO_Central.
DR GO; GO:0060964; P:regulation of miRNA-mediated gene silencing; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IBA:GO_Central.
DR CDD; cd21992; HMG-box_MAEL; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024970; Maelstrom.
DR InterPro; IPR039259; Protein_maelstrom.
DR PANTHER; PTHR21358; PROTEIN MAELSTROM HOMOLOG; 1.
DR PANTHER; PTHR21358:SF4; PROTEIN MAELSTROM HOMOLOG; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR Pfam; PF13017; Maelstrom; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158}.
FT DOMAIN 2..71
FT /note="HMG box"
FT /evidence="ECO:0000259|Pfam:PF09011"
FT DOMAIN 130..312
FT /note="Maelstrom"
FT /evidence="ECO:0000259|Pfam:PF13017"
FT REGION 62..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 47376 MW; 46865B1A88408143 CRC64;
MPNRRASRNA YYFFVQEKIP ELRRRGLPVA RVADAIPYCS ADWALLKEEE KEKYAEMARE
WRAAQGKDSG PSEKQKPVCT PLRKPGMLVP KQNVSPPDLS GLSLKSDQAL LGGIFYFLNI
FSHGELPPHC EQRFLPCEIG CVKYSLQEGI MADFHSFINP GDSSHKIPIS HFESGHDQAT
VLENLYRFIH PNPGNWPPIY CKSDDRARVN WCLKHMAKSS EIRQDLELLT VEDLVVGIYQ
QKFLKEPSKT WVRSLLEVAM WDYSSNTRCK WHEENDILFC ALAVCKKIAY CISNSLATLF
GIQLTEAHVP LQDYEASNSV TPKMVVLDAG RYQKLRVESP GFSHFSSSNQ EQRSNTPTGD
YPSGVKISGQ NSSVRGRGIT RLLESISSSS SNIHKFSNCE TPVSPYTSPK HGYKSFSSLS
//
