ID F1MMJ6_BOVIN Unreviewed; 1330 AA.
AC F1MMJ6;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Capping protein regulator and myosin 1 linker 1 {ECO:0000313|Ensembl:ENSBTAP00000022015.5};
GN Name=CARMIL1 {ECO:0000313|Ensembl:ENSBTAP00000022015.5,
GN ECO:0000313|VGNC:VGNC:26768};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000022015.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000022015.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022015.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000022015.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000022015.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CARMIL family.
CC {ECO:0000256|ARBA:ARBA00007298}.
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DR RefSeq; NP_001179832.1; NM_001192903.1.
DR SMR; F1MMJ6; -.
DR PaxDb; 9913-ENSBTAP00000022015; -.
DR Ensembl; ENSBTAT00000022015.6; ENSBTAP00000022015.5; ENSBTAG00000016549.6.
DR GeneID; 537314; -.
DR KEGG; bta:537314; -.
DR CTD; 55604; -.
DR VEuPathDB; HostDB:ENSBTAG00000016549; -.
DR VGNC; VGNC:26768; CARMIL1.
DR eggNOG; KOG4242; Eukaryota.
DR GeneTree; ENSGT00940000155112; -.
DR HOGENOM; CLU_003119_3_0_1; -.
DR TreeFam; TF316381; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000016549; Expressed in mammary gland and 104 other cell types or tissues.
DR ExpressionAtlas; F1MMJ6; baseline and differential.
DR Gene3D; 6.10.140.1850; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR031943; CARMIL_C.
DR InterPro; IPR041245; CARMIL_PH.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR24112:SF39; F-ACTIN-UNCAPPING PROTEIN LRRC16A; 1.
DR PANTHER; PTHR24112; LEUCINE-RICH REPEAT, ISOFORM F-RELATED; 1.
DR Pfam; PF17888; Carm_PH; 1.
DR Pfam; PF16000; CARMIL_C; 1.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 1: Evidence at protein level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1MMJ6};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 26..119
FT /note="CARMIL pleckstrin homology"
FT /evidence="ECO:0000259|Pfam:PF17888"
FT DOMAIN 786..1078
FT /note="CARMIL C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16000"
FT REGION 955..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1330 AA; 147365 MW; 3762A2F2F965F64F CRC64;
MAEESSEVPG ELIESIKDVL GRKIKIALKK KVKLEVKGDK VENRVLVLTS CRAFLVTARI
PTKLEVTFSY LEIHGVICSK PAQMVVETEK CSISMKMASP EDVSEVLAHI GTNLRKIFPG
LSPVRIMKKV FMEPSERLAS LQALWDSQTV TEQGPCGGFS QMYACVCDWL GFSYREEVQW
DVDTIYLTQD TRELNLQDFS HLDHRDLIPI IAALEYNQWF TKLSSKDLKL STDVCEQILR
VVSRSNRLEE LVLENAGLRI DFAQKLASAL AHNPTSGLHT INLAGNPLED RGVSSLSIQF
AKLPKGLKHL NLSKTSLSPK GVNSLSQSLS ANPLTATTLV HLDLSGNILR GDDLSSMYSF
LAQPNAIAHL DLSNTECSLD MVCGALLRGC LQYLAVLNLS RTVFSHRKGK EVPPSFKQFF
SSSLALMQIN LSGTKLSPEP LKALLLGLAS NHNLKGVSLD LSNCELRSGG AQVLEGCIAE
IHNISSLDIS DNGLESDLST LIVWLSKNRS IQHLALGKNF NNMKSKNLTP VLDNLVQMIQ
DEESPLQSLS LADSKLKTGV TIIINALGSN TSLTKVDISG NGMGDMGAKM LAKALQINTK
LRTVIWDKNN ITAQGFQDIA VAMEKNYTLR FMPIPMYDAS QALKTNPEKT EEALQKIENY
LLRNHETRKY LQEQAYRLQQ GIVTSTTQQM IDRMCVKVQD HLNSLRSCEG DAVQEDLKSA
ERLMQDAKNS KTLLPNLYHV GSVSWAGASG LLSSPIQETL ESMAGEVTRV VDEQLKALLE
SMVDAAENLC PNVMRKAHIR QDLIHASTEK ISIPRTFVKN VLLEQSGIDI LNKISEVKLT
VASFLSDRIV DEILDALSHC HHKLADHFSR RGKTLLQQDS LEMELAEEKP VKRSIITVEE
LTEIERLEDL DTCMMTPKSK RKTIHSRMLR PVSRAFEMEF DLDKALEEVP IHIEDPPFPS
IRQEKRSSGF ISDLPSEEGR KLEHFTKLRP KRAKKQQSTH PAGCATSIVS QDGEQNGLMG
RVDEGVDEFF TKKVTKMDSK RWSARGSESH ELSEGGDEKK KRDFRKTGFL NLIKPRNKPE
RSSTVLTAEE LSSPKAGVRS PAVDAPRKDT KPAEHNGSAD RVEEIKTPDS LEESQGEDVG
KVDRSDSKGS PQGGRRYGVQ MMGSGLLAEM KAKQEMKNRF GLGTPEKNAK ADLKAEAVSK
PRSFSNRPTS PKPLLQAPKP NLAARPTIPQ KPRTASRPED VPDSPSSPGS PKVALLPPVL
KKVPSDKERD GQGSPQPSPR TFSREVSRRS WSQQAQECQE QKQWASSKDG QPGSKSSDSG
EEAEREYIFV
//
