ID F1MQ21_BOVIN Unreviewed; 1798 AA.
AC F1MQ21;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Nestin {ECO:0000313|Ensembl:ENSBTAP00000020974.6};
GN Name=NES {ECO:0000313|Ensembl:ENSBTAP00000020974.6,
GN ECO:0000313|VGNC:VGNC:32009};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000020974.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000020974.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020974.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000020974.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020974.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; NP_001193520.1; NM_001206591.1.
DR SMR; F1MQ21; -.
DR STRING; 9913.ENSBTAP00000020974; -.
DR PaxDb; 9913-ENSBTAP00000020974; -.
DR Ensembl; ENSBTAT00000020974.6; ENSBTAP00000020974.6; ENSBTAG00000015794.6.
DR GeneID; 522383; -.
DR KEGG; bta:522383; -.
DR CTD; 10763; -.
DR VEuPathDB; HostDB:ENSBTAG00000015794; -.
DR VGNC; VGNC:32009; NES.
DR eggNOG; ENOG502RYFK; Eukaryota.
DR GeneTree; ENSGT00940000162240; -.
DR HOGENOM; CLU_003317_0_0_1; -.
DR InParanoid; F1MQ21; -.
DR OMA; RKEGWDP; -.
DR OrthoDB; 4204342at2759; -.
DR TreeFam; TF336633; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000015794; Expressed in laryngeal cartilage and 101 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IBA:GO_Central.
DR GO; GO:0031730; F:CCR5 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0019215; F:intermediate filament binding; IEA:InterPro.
DR GO; GO:0030844; P:positive regulation of intermediate filament depolymerization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR031211; Nestin.
DR PANTHER; PTHR47051; NESTIN; 1.
DR PANTHER; PTHR47051:SF1; NESTIN; 1.
DR Pfam; PF00038; Filament; 2.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 8..313
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 152..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..1798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 12..46
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 218..284
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 569..611
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 450..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..690
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..888
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 895..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..1008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1044
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1317..1356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1461..1475
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1555
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1593..1614
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1669..1684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1798 AA; 197278 MW; 17A090A7B82C1F6A CRC64;
MEGCLGEESF QMWELNRRLE AYLARVKALE EQNELLSAEL GGLRAQAGDT SWRARADDEL
AALRALVDQR WREKHAAEVA RDNLAEEVEG VASRCQQLRL ARERTAEEVA RSRRAVEAEK
CAQAWLSTQA AELERELEAL RVAQEEERAG LNAQAACAPR GSAPPRGPPA PAPEVEELAQ
RLGEAWRGAV RGYQERVAHM ETSLGQARER LGHAMQGARE GRLELQQLQA ERSGLQERRA
ALEQRLEGRW QERLRTTEQF QLAVEALEQE KQGLQSQIAQ VLEGRQQLAH LKMSLSLEVA
TYRTLLEAEN SRLQTPASGS KASLSFLDPK LELHFPGTPE GRRPGPLLSV LSPTPLSSPL
PGTLETPVPT FLKSQEFLQA RTPTSASTPI PPTPQAPCPA VDAEIRAQDA PVSLPQARVG
RQQVPEVMWA EAKVAIPASV LPGPEEPGGQ QQEPSPSQSP EDHASLAPAL SPDHSSLETK
DGEPSASRES SRSQEEDEGQ LWGLTEKETV VEAKAVSSLQ QETCQEEAGL DVKEIQDAQG
PLEKEALNSL EEEIQKPSIP LEKQSHETIR SLEKENLESL RSLEEENLET LKILEKENQE
LLKSLEGKET EVMRSLEKET LELLKPIGKE DPQTLPSLGK ENQEIMRSLE VNVETFLYPG
KENQELVRSL EEENAESLRT LEKESQEPLR CQEVENQGTL RLLAKDNQEP LRSLEEEDQE
TSRPLGKENH ESLRAPEDEN HEALRPLERD KPESLSSLEE DQEAVRPPER EDQELLRSLE
KEDQEPLRSL EEDQEAVRPL EEENQELLRS LEKEKEESLR SLEDQEAMRP LEEENQEPLR
SLEDQEAMRP LEEENQEPLR SLEKEKQEAT RPPEEEKQEP LMSLEEDQEE MRALEEDQET
VRPLEKEKQE SLRSLEDHEA MRPLEEENQE PLRSLEKEKQ EVMRPPEEEK QELLRSLEDQ
EAMRSLEEEG QMTLSPLEKV KPETLKSLGK DQEIVRPLEK ENQELLRSLN EKSTEAVRSL
ETETPEPLKP TEEENLEILK PLEKESQEPL GSVEGNHETL RPPEKENQES LGSLAEWNVE
NLQSLEEADK GSLRHLEEEE DVEQEESQAS LRPLEEQGQE LPLSAQQQKW GDAMQGDQEL
DQERPPGRAG VDSGDGAELE LKELDSSPAE GEVVEQGQLQ LTATGEAWGP GEGQPGSPEP
KEQRLPAEGA GGAGGAAGLQ DPEEQPEQVG ALGLPAAQGT SEVMEPELED EDVAPGGGRA
SPEVTLELER AMGRSEGVER GPEQEAVKLE DPGGLAREEV MEPPLGEGGM AAKKVQGLEG
PRKELEEAGT LEPESGKSRD PLETPRDWEE SESGALGKTE EPVSAETLWS HEGSDTLQPR
PLGSEGAEED AKPLLGPPSL RPTESCLPSL IPEDAPGPQP LAEGNQEASW GLEGRAEVVG
KAGGEQEDLG SGGIPEGLQE EGEESREESE ADELGETLPD STPLGLYLRS PASPKWDLPG
EQRPSPQGEP RKEGWDPVVP ASKSLGAQPS EEEEEEGAEE EERGHDSELS EEFEDLGTEA
SLLPGVPGEG EEPLSQVPQL LLEPAAWDRD GESDGFADEE ESGEEGEEED EEEGREPGPG
HWGPAPSVGS LPALSGPQGG HLLESETVGV SVPWDDGPRG AAADAPVTAL ETESQNSTEA
SGSEEESDAA PLETEDQVPG PLGTLSGVED TLDGGPGPSL KEELERMNGG VVNGLEQSEG
GGQGKPGAAG GDRGSPSEEE GASLKAPWAG APLHLGQGQF LKFSQREGDG DSWSSGED
//
