ID F1MQF0_BOVIN Unreviewed; 544 AA.
AC F1MQF0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Intercellular adhesion molecule 3 {ECO:0000313|Ensembl:ENSBTAP00000020903.2};
GN Name=ICAM3 {ECO:0000313|Ensembl:ENSBTAP00000020903.2,
GN ECO:0000313|VGNC:VGNC:50198};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000020903.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000020903.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020903.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000020903.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000020903.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. ICAM family.
CC {ECO:0000256|ARBA:ARBA00005925}.
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DR AlphaFoldDB; F1MQF0; -.
DR SMR; F1MQF0; -.
DR Ensembl; ENSBTAT00000020903.3; ENSBTAP00000020903.2; ENSBTAG00000015742.3.
DR VEuPathDB; HostDB:ENSBTAG00000015742; -.
DR VGNC; VGNC:50198; ICAM3.
DR GeneTree; ENSGT00940000159005; -.
DR HOGENOM; CLU_036160_1_1_1; -.
DR InParanoid; F1MQF0; -.
DR OMA; MHILQCQ; -.
DR TreeFam; TF333745; -.
DR Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-BTA-216083; Integrin cell surface interactions.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000015742; Expressed in neutrophil and 104 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR CDD; cd20997; IgI_N_ICAM-3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR003988; ICAM.
DR InterPro; IPR048679; ICAM1_3_5_D2.
DR InterPro; IPR013768; ICAM_N.
DR InterPro; IPR047012; ICAM_VCAM.
DR InterPro; IPR003987; ICAM_VCAM_N.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR13771; INTERCELLULAR ADHESION MOLECULE; 1.
DR PANTHER; PTHR13771:SF17; INTERCELLULAR ADHESION MOLECULE 3; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF21146; ICAM1_3_5_D2; 1.
DR Pfam; PF03921; ICAM_N; 1.
DR PRINTS; PR01473; ICAM.
DR PRINTS; PR01472; ICAMVCAM1.
DR SMART; SM00409; IG; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..544
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003267520"
FT TRANSMEM 490..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..116
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 126..209
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 322..398
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT DOMAIN 409..481
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
SQ SEQUENCE 544 AA; 59752 MW; 9F3E7E826BA5DE11 CRC64;
MMPSGPPPRV YWTSLIFLLL ACCLLPTGAQ GQTYQVRVEP KDPVVPFGEP LVVNCTLDCP
GPGLISLETA LSKEPHSRGL GWAAFRLTNV TGDMEILCSG ICNKSQVVGF SNITVFGFPK
RVELAPLPLW QPVGEELNLS CLVSGGAPRA HLSVVLLRGE EELGQQPLGK EEPAKVTFMV
QPRREDHGTN FSCRSELDLR SQGLELFQNT SAPRKLQTYA MPKTAPRLVF PRFWEMETSW
PVNCSLDGLF PASEAHIQLA LGNQMLNATV VSHADTLTAT ATAKTEQEGT QEIVCNVTLG
VENRETRESL VAYRFQGPNL NLSESNATEG TPVTVTCAAG PQVQVMLDGV PAAVPGQPAQ
LQLKATEMDD RRTFFCNATL KVHGVTLHRN RSIQLRVLYG PTIDRAKCPQ RLMWKEKTMH
ILQCQARGNP NPQLQCLREG SKFKVPVGIP FLVLLNYSGT YSCQAASSRG TDKMLVMMDV
QGRNPVTINI VLGVLAILGL VTLAAASVYV FWVQRQHDIY HLTPRSTRWR LTSTQPVTVA
EELS
//
