ID F1MQH3_BOVIN Unreviewed; 677 AA.
AC F1MQH3;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=FERM domain containing kindlin 1 {ECO:0000313|Ensembl:ENSBTAP00000027271.4};
GN Name=FERMT1 {ECO:0000313|Ensembl:ENSBTAP00000027271.4,
GN ECO:0000313|VGNC:VGNC:28952};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000027271.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000027271.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027271.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000027271.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000027271.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR RefSeq; NP_001193108.1; NM_001206179.2.
DR RefSeq; XP_005214782.1; XM_005214725.3.
DR RefSeq; XP_010809776.1; XM_010811474.2.
DR PaxDb; 9913-ENSBTAP00000027271; -.
DR Ensembl; ENSBTAT00000027271.5; ENSBTAP00000027271.4; ENSBTAG00000020465.6.
DR Ensembl; ENSBTAT00000083320.1; ENSBTAP00000059533.1; ENSBTAG00000020465.6.
DR GeneID; 524427; -.
DR KEGG; bta:524427; -.
DR CTD; 55612; -.
DR VEuPathDB; HostDB:ENSBTAG00000020465; -.
DR VGNC; VGNC:28952; FERMT1.
DR eggNOG; KOG3727; Eukaryota.
DR GeneTree; ENSGT00390000013444; -.
DR HOGENOM; CLU_011611_0_0_1; -.
DR OMA; GMFFCAP; -.
DR OrthoDB; 5399911at2759; -.
DR TreeFam; TF314677; -.
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000020465; Expressed in oviduct epithelium and 102 other cell types or tissues.
DR GO; GO:0071944; C:cell periphery; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0071711; P:basement membrane organization; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0090162; P:establishment of epithelial cell polarity; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0051546; P:keratinocyte migration; IEA:Ensembl.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0042308; P:negative regulation of protein import into nucleus; IEA:Ensembl.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0051886; P:negative regulation of timing of anagen; IEA:Ensembl.
DR GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0033625; P:positive regulation of integrin activation; IEA:Ensembl.
DR GO; GO:0071636; P:positive regulation of transforming growth factor beta production; IEA:Ensembl.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1903691; P:positive regulation of wound healing, spreading of epidermal cells; IEA:Ensembl.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17180; FERM_F0_KIND1; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF12; FERMITIN FAMILY HOMOLOG 1; 1.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 377..473
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 677 AA; 77223 MW; 4B8DD4BCB2427695 CRC64;
MLSSSDFASA SWELVVRVDH PNEEEQKDIT LRVSGDLHIG GVMLKLVEQI NIAQDWSDFA
LWWEQKHCWL LKTHWTLDKC GVQADAKLVF TPQHKMLRLR LPNMKTVRLR VSFSTVVFRA
VSDICRALNI RRAEELSLLK PSGEYFKKKK KKDKNNKEPI IEDILNLEGS PTISGPSVSP
GLYSKTMTPT YDPINGTPAS STMTWFSDSP LAEQNCSILA FSQPPQSPEA LADMYQSRSL
ADKAKLNSGW LDSSRSLMEQ GIQEDEQLLL RFKYYTFFDL NPKYDAVRIN QLYEQARWAI
LLEEIDCTEE EMLIFAALQY HISKLSLSTE IQDFTNESEV DEVEAALSNL EVTLEGGKAD
NTLEDITDIP KLADNLRLFR PKKLILKAFK QYWFVFKDTS IAYFKNKELE QGEPVEKLNL
RGCEVVPDVN VAGRKFGIKL LIPVADGMNE VYLRCDHESQ YAQWMAACIL ASKGKTMADS
SYQPEVLNIL SFLKMKNRNS APQVASGLEN MDMNPECFVS PRCAKKHKSK QLAACILEAH
QNVAQMPLVE AKLRFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGISYNRL IRIDAATGIP
ITTWRFTNMK QWNVNWEIRQ VAIEFDQNVS IAFTCLSADC KVVHEYIGGY IFLSTRSKDQ
NETLDEDLFH KLTGGQE
//
