ID F1MSJ0_BOVIN Unreviewed; 865 AA.
AC F1MSJ0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSBTAP00000029529.4};
GN Name=TPCN1 {ECO:0000313|Ensembl:ENSBTAP00000029529.4,
GN ECO:0000313|VGNC:VGNC:36243};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000029529.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000029529.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029529.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000029529.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000029529.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F1MSJ0; -.
DR Ensembl; ENSBTAT00000029530.4; ENSBTAP00000029529.4; ENSBTAG00000011102.5.
DR VEuPathDB; HostDB:ENSBTAG00000011102; -.
DR VGNC; VGNC:36243; TPCN1.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000158958; -.
DR HOGENOM; CLU_019500_0_0_1; -.
DR TreeFam; TF328550; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000011102; Expressed in oviduct epithelium and 103 other cell types or tissues.
DR ExpressionAtlas; F1MSJ0; baseline and differential.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 157..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 527..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..741
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..380
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 491..741
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 15..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 865 AA; 99132 MW; 6327B80F90B5C5BD CRC64;
MAVSLDDDVP LILTLDEGGS APLAPSNGLG PDDLPSRTEG ESSTAGPPGT SPSGPFLSCA
WILHGLSSQG PPPTCLNGPS KTQIRADGGK YTVHDSQAPS LSLEGENSPS SPTEHDWEMN
YQEAAIYLQE GENNDKFFTH PKNAKALAAY LFAHNHLFYL MELSAALLLL LLSLCEAPAV
PALRLGIYVH ATLELFALVV VVFELCMKLR WLGLHTFIRH RRTMVKTSVL VVQFVEAIVV
LVRQTSHMRV TRALRCIFLV DCRYCGGVRR NLRQMFQSLP PFMDILLLLL FFMIIFAILG
FYLFSPNPSD PYFSTLENSI ISLFVLLTTA NFPDVMMPSY SRNPWSCVFF IVYLSIELYF
IMNLLLAVVF DTFNDIEKRK FKSLLLHKRT AIQHAYRLLV SQRRPAGISY RQFEGLMRFY
KPRMSAGERY LTFKALNQSN TPLLSLKDFH DIYEVAALKW KAKRNREHWF DELPRTAFLI
FKGINILVKS KAFQYFMYLV VAVNGVWILV ETFMLKGGNF VSRHVPWSHL VFLTIYAVEL
FLKVAGLGPI EYLSSGWNLF DFSVTAFAFL GLLALAFNME PFYFIVVLRP LQLLRLFKLK
KRYRNVLDTM FELLPRMASL GLTLLIFYYS FAIVGMEFFY GILYPNCCNT STVADAYRWL
NHSVGNRTVV EEGYYYLNNF DNILNSFVTL FELTVVNNWY IIMEGVTSQT SHWSRLYFMT
FYIVTMVVMT IIVAFILEAF VFRMNYSRKN QDSEVDDGIT LEKELSKDEL VAVLKLYREA
GGANSDIAQL LKILSQLERY EQNTLVFLGR RSRTKSDLSL KMYQEEIQEW YEEHARKQEE
RQLSSCVVPA TQQPPGSRQR SQTIT
//