ID F1MSR5_BOVIN Unreviewed; 924 AA.
AC F1MSR5;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=TBC1 domain containing kinase {ECO:0000313|Ensembl:ENSBTAP00000005539.6};
GN Name=TBCK {ECO:0000313|Ensembl:ENSBTAP00000005539.6,
GN ECO:0000313|VGNC:VGNC:35655};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000005539.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000005539.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005539.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000005539.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000005539.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1MSR5; -.
DR SMR; F1MSR5; -.
DR STRING; 9913.ENSBTAP00000005539; -.
DR PaxDb; 9913-ENSBTAP00000005539; -.
DR Ensembl; ENSBTAT00000005539.6; ENSBTAP00000005539.6; ENSBTAG00000004227.6.
DR VEuPathDB; HostDB:ENSBTAG00000004227; -.
DR VGNC; VGNC:35655; TBCK.
DR eggNOG; KOG1093; Eukaryota.
DR GeneTree; ENSGT00940000158244; -.
DR HOGENOM; CLU_011160_0_0_1; -.
DR InParanoid; F1MSR5; -.
DR TreeFam; TF106242; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000004227; Expressed in cumulus cell and 108 other cell types or tissues.
DR ExpressionAtlas; F1MSR5; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR GO; GO:0032006; P:regulation of TOR signaling; IEA:Ensembl.
DR CDD; cd01525; RHOD_Kc; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR PANTHER; PTHR24345:SF87; TBC1 DOMAIN CONTAINING KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00450; RHOD; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 12..304
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 497..682
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT DOMAIN 821..920
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT REGION 742..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 924 AA; 104451 MW; 69EEAA7884F80A1E CRC64;
MIKCWTPFVL ETILLDPSGT SDYLGRFRTR RMFPLKDAEM GAFTFFASAL PHDVCGSNGL
PLTPNSIKIL GRFQILKTIT HPRLCQYVDI SRGKHERLVV VAEHCERSLE DLLREGKPVS
YSKVLCIAFE VLQGLQYMNK HGIVHRALSP HNILLDQKGH VKLAKFGLYH MTAYGDDVDF
PIGYPSYLAP EVIAQGIFKT SDHVPSEKPL PSGPKSDVWS LGIILFELCV GRKLFQSLDI
SERLKFLLTL DCVDDTIIVL AEEHGCLDII KELPETVIDL LKKCLTFHPS KRPTPDELMQ
DNVFSEVLPL YPPFIKPASL FSSSLRCADL TLPEDISQLY EDINSDYLAE RSIEEVYYLW
CLAGGDLEKE LVNKEIIRSK PPICTLPNFL FEDGESFGQG RDRSSLLDDT TVTLSLCQLR
NRLKDVGGEA FYPLLEDDQS NLPHSNSNNE LSAAATLPLI IRERDTEYQL NRIILFDRLL
KAYPYKKNQI WKEARVDIPP LMRGLTWAAL LGVEGAIHAK YDAIDKDTPI PTDRQIEVDI
PRCHQYDELL SSPEGHAKFR RVLKAWVVSH PDLVYWQGLD SLCAPFLYLN FNNEALAYAC
MSAFIPKYLY NFFLKDNSHV IQEYLTVFSQ MIAFHDPELS NHLNEIGFIP DLYAIPWFLT
MFTHVFPLHK IFHLWDTLLL GNSSFPFCIG VAILQQLRDR LLANGFNECI LLFSDLPEID
IERCVRESIN LFCWTPKSAT YRQHAQPPKP TSDSSGVRSS TPYFPTECPD PPKTDLSRES
IPLNDLKSEV SPRISAEDLI DLCELTVTGH FKTPTKKTKS SKPKLLVVDI RNSEDFVRGH
ISGSINIPFS TAFTAEGELT QGPYTAMLQS FKGKVIVIVG NVAKHTAEFA AHLVKMKYPR
ICILDGGINK IKPTGLLTVP SPQI
//
