ID F1MTV1_BOVIN Unreviewed; 553 AA.
AC F1MTV1;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 03-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Hyaluronidase {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
DE EC=3.2.1.35 {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
GN Name=SPAM1 {ECO:0000313|Ensembl:ENSBTAP00000006089.3};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000006089.3, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000006089.3, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006089.3,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000006089.3}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000006089.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00000251,
CC ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC {ECO:0000256|ARBA:ARBA00008871, ECO:0000256|PIRNR:PIRNR038193,
CC ECO:0000256|RuleBase:RU610713}.
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DR RefSeq; NP_001008413.3; NM_001008413.3.
DR RefSeq; XP_005205684.1; XM_005205627.3.
DR AlphaFoldDB; F1MTV1; -.
DR SMR; F1MTV1; -.
DR STRING; 9913.ENSBTAP00000006089; -.
DR GlyCosmos; F1MTV1; 1 site, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000006089; -.
DR Ensembl; ENSBTAT00000006089.4; ENSBTAP00000006089.3; ENSBTAG00000004640.4.
DR GeneID; 353352; -.
DR KEGG; bta:353352; -.
DR CTD; 6677; -.
DR VEuPathDB; HostDB:ENSBTAG00000004640; -.
DR eggNOG; ENOG502R6HD; Eukaryota.
DR GeneTree; ENSGT01020000230364; -.
DR HOGENOM; CLU_036366_0_1_1; -.
DR InParanoid; F1MTV1; -.
DR OMA; PLWEQNW; -.
DR OrthoDB; 5344684at2759; -.
DR TreeFam; TF321598; -.
DR Proteomes; UP000009136; Chromosome 4.
DR Bgee; ENSBTAG00000004640; Expressed in spermatid and 91 other cell types or tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004415; F:hyalurononglucosaminidase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:InterPro.
DR GO; GO:0030214; P:hyaluronan catabolic process; IBA:GO_Central.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR018155; Hyaluronidase.
DR InterPro; IPR001439; Hyaluronidase_PH20/Hyal5.
DR PANTHER; PTHR11769; HYALURONIDASE; 1.
DR PANTHER; PTHR11769:SF20; HYALURONIDASE PH-20; 1.
DR Pfam; PF01630; Glyco_hydro_56; 1.
DR PIRSF; PIRSF038193; Hyaluronidase; 1.
DR PIRSF; PIRSF500773; Hyaluronidase_PH20_Hyal5; 1.
DR PRINTS; PR00846; GLHYDRLASE56.
DR PRINTS; PR00848; SPERMPH20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00022622};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR038193};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..553
FT /note="Hyaluronidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003267600"
FT REGION 477..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 149
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-1"
FT CARBOHYD 370
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-2"
FT DISULFID 60..353
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 225..239
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 378..389
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 383..437
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
FT DISULFID 439..445
FT /evidence="ECO:0000256|PIRSR:PIRSR038193-3"
SQ SEQUENCE 553 AA; 62281 MW; 63B68C2A38B6DB35 CRC64;
MRMLRRHHIS FRSFAGSSGT PQAVFTFLLL PCCLALDFRA PPLISNTSFL WAWNAPVERC
VNRRFQLPPD LRLFSVKGSP QKSATGQFIT LFYADRLGYY PHIDEKTGKT VFGGIPQLGN
LKSHLEKAKN DIAYYIPNDS VGLAVIDWEN WRPTWARNWK PKDVYRDESV ELVLQKNPQL
SFPEASKIAK VDFETAGKSF MQETLKLGKL LRPNHLWGYY LFPDCYNHNH NQPTYNGNCP
DVEKRRNDDL EWLWKESTAL FPSVYLNIRL KSTQNAALYV RNRVQEAIRL SKIASVESPL
PVFVYARPVF TDGSSTYLSQ GDLVNSVGEI VSLGASGIIM WGSLNLSLSM QSCMNLGTYL
NTTLNPYIIN VTLAAKMCSQ VLCHNEGVCT RKHWNSSDYL HLNPMNFAIQ TGEGGKYTVP
GTVTLEDLQK FSDTFYCSCY ANIHCKKRVD IKNVHSVNVC MAEDICIDSP VKLQPSDHSS
SQEASTTTFS SISPSTTTAT VSPCTPEKHS PECLKVRCSE VIPNVTQKAC QSVKLKNISY
QSPIQNIKNQ TTY
//