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Database: UniProt
Entry: F1MW38_BOVIN
LinkDB: F1MW38_BOVIN
Original site: F1MW38_BOVIN 
ID   F1MW38_BOVIN            Unreviewed;      1035 AA.
AC   F1MW38;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   10-OCT-2018, entry version 50.
DE   SubName: Full=Cysteine rich transmembrane BMP regulator 1 {ECO:0000313|Ensembl:ENSBTAP00000011877};
GN   Name=CRIM1 {ECO:0000313|Ensembl:ENSBTAP00000011877,
GN   ECO:0000313|VGNC:VGNC:27710};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000011877, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000011877, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011877,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000011877}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000011877};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   EMBL; DAAA02030556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001192227.1; NM_001205298.1.
DR   ProteinModelPortal; F1MW38; -.
DR   STRING; 9913.ENSBTAP00000011877; -.
DR   PaxDb; F1MW38; -.
DR   Ensembl; ENSBTAT00000011877; ENSBTAP00000011877; ENSBTAG00000009020.
DR   GeneID; 506264; -.
DR   KEGG; bta:506264; -.
DR   CTD; 51232; -.
DR   VGNC; VGNC:27710; CRIM1.
DR   eggNOG; ENOG410IR8F; Eukaryota.
DR   eggNOG; ENOG410Z6K0; LUCA.
DR   GeneTree; ENSGT00840000129763; -.
DR   InParanoid; F1MW38; -.
DR   OMA; CPLPSRC; -.
DR   OrthoDB; EOG091G01IV; -.
DR   TreeFam; TF106451; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000009020; Expressed in 9 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
DR   GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0001558; P:regulation of cell growth; IEA:InterPro.
DR   InterPro; IPR004094; Antistasin-like.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR011061; Hirudin/antistatin.
DR   InterPro; IPR000867; IGFBP-like.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF02822; Antistasin; 4.
DR   Pfam; PF00219; IGFBP; 1.
DR   Pfam; PF00093; VWC; 6.
DR   SMART; SM00121; IB; 1.
DR   SMART; SM00214; VWC; 6.
DR   SMART; SM00215; VWC_out; 3.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   SUPFAM; SSF57262; SSF57262; 3.
DR   PROSITE; PS51252; ANTISTASIN; 4.
DR   PROSITE; PS51323; IGFBP_N_2; 1.
DR   PROSITE; PS01208; VWFC_1; 3.
DR   PROSITE; PS50184; VWFC_2; 6.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     34       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        35   1035       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003269751.
FT   TRANSMEM    939    959       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       33    112       IGFBP N-terminal. {ECO:0000259|PROSITE:
FT                                PS51323}.
FT   DOMAIN      334    391       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      401    457       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      469    498       Antistasin-like. {ECO:0000259|PROSITE:
FT                                PS51252}.
FT   DOMAIN      505    532       Antistasin-like. {ECO:0000259|PROSITE:
FT                                PS51252}.
FT   DOMAIN      539    564       Antistasin-like. {ECO:0000259|PROSITE:
FT                                PS51252}.
FT   DOMAIN      567    592       Antistasin-like. {ECO:0000259|PROSITE:
FT                                PS51252}.
FT   DOMAIN      606    663       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      677    735       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      751    809       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      817    874       VWFC. {ECO:0000259|PROSITE:PS50184}.
SQ   SEQUENCE   1035 AA;  113958 MW;  0B2BF8FB39915D5A CRC64;
     MYLVAGGRGM AGCGHLLVSL QGLLLLLARS GTRALVCLPC DESKCEEPKS CPGSIVQGFC
     GCCYMCARQR NESCGGAYGL HGACDRGLRC VIRPPLNGDS ITEYEVGVCE DENWDDDQLL
     GFEPCNENLV SGCNLINGKC ECDTIRTCNN PFEFPRKDMC LSALKRIEEE KPDCSKARCE
     VQFSPRCPED SVLIEGYAPP GECCPLPSRC VCDPAGCLRK VCQPGYLNIL LKRASGKPGE
     CCDLYECKPV FSVDCSTVEC PSFQQTVCPL DSYETQVRLT ADGCCTLPTR CECLSGLCGF
     PVCEVGSTPR IVSRGDGTPG KCCDVFECVN ETKPACVFNN VEYGDGDMFR MDNCRFCRCQ
     GGVSICFTAQ CGELSCERYY MPEGECCPVC EDPVYPLNNP AGCYANGQIH AHGDRWREDD
     CTFCQCINGE PHCVATACGQ SCMSPVKVPG ECCPVCEEPT YITIDPPACG ELSNCTLTEK
     DCIYGFKLDH NGCRTCQCKN REELCTGLRR GCTLNCPFGF LTDAYGCETC QCRPRPRKCR
     PTVCEKHCPF GYLKNKHGCD ICRCKKCPEL RCSKICSLGF QKDSHGCLIC KCREVSASAG
     PPVLSGTCLS MDGHHHKNGE SWHDGCRECY CHSGREMCAL ITCPVPACGN PTIHPGRCCP
     SCSDDFVVQK PELSTPSICH APGGEYFVEG ETWHIDTCTQ CTCHSGRVLC ETEVCPPLLC
     QNPTRTQDSC CPQCPDEPLQ PSSSHNDSVP SYCKNDEGDI FLAAESWKPD VCTSCVCMDS
     VISCYSESCP SVSCERPVLR KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDIDSCTHC
     YCLQGQTLCS TVSCPPLPCI EPINMEGSCC PMCPEMYVPE PTNIPIEKTN HREIDMEVPL
     WPTPSENDII HLPRDVGHPQ TDHRENTRLN SEESSVDSIA SVVVPIIIGL SIVIAFLFIN
     QKKQWVPLLC WYRTPTKPSS LNNQLVSVDC KKGTRVQVDG SQRMLRIAEP DARFSGFYSM
     QKQNHLQADN FYQTV
//
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