ID F1MWE0_BOVIN Unreviewed; 440 AA.
AC F1MWE0;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Proteasome 26S subunit, ATPase 3 {ECO:0000313|Ensembl:ENSBTAP00000028983.6};
GN Name=PSMC3 {ECO:0000313|Ensembl:ENSBTAP00000028983.6,
GN ECO:0000313|VGNC:VGNC:33456};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000028983.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000028983.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028983.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000028983.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028983.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
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DR RefSeq; NP_001179113.2; NM_001192184.2.
DR AlphaFoldDB; F1MWE0; -.
DR SMR; F1MWE0; -.
DR STRING; 9913.ENSBTAP00000028983; -.
DR PaxDb; 9913-ENSBTAP00000028983; -.
DR Ensembl; ENSBTAT00000028983.6; ENSBTAP00000028983.6; ENSBTAG00000021744.6.
DR GeneID; 508448; -.
DR KEGG; bta:508448; -.
DR CTD; 5702; -.
DR VEuPathDB; HostDB:ENSBTAG00000021744; -.
DR VGNC; VGNC:33456; PSMC3.
DR eggNOG; KOG0652; Eukaryota.
DR GeneTree; ENSGT01020000230346; -.
DR HOGENOM; CLU_000688_2_4_1; -.
DR InParanoid; F1MWE0; -.
DR OMA; NKISHEH; -.
DR OrthoDB; 1707207at2759; -.
DR TreeFam; TF105648; -.
DR Reactome; R-BTA-1169091; Activation of NF-kappaB in B cells.
DR Reactome; R-BTA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
DR Reactome; R-BTA-1236978; Cross-presentation of soluble exogenous antigens (endosomes).
DR Reactome; R-BTA-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-BTA-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-BTA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-BTA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-BTA-187577; SCF(Skp2)-mediated degradation of p27/p21.
DR Reactome; R-BTA-195253; Degradation of beta-catenin by the destruction complex.
DR Reactome; R-BTA-202424; Downstream TCR signaling.
DR Reactome; R-BTA-2467813; Separation of Sister Chromatids.
DR Reactome; R-BTA-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-BTA-349425; Autodegradation of the E3 ubiquitin ligase COP1.
DR Reactome; R-BTA-350562; Regulation of ornithine decarboxylase (ODC).
DR Reactome; R-BTA-382556; ABC-family proteins mediated transport.
DR Reactome; R-BTA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA.
DR Reactome; R-BTA-4608870; Asymmetric localization of PCP proteins.
DR Reactome; R-BTA-4641257; Degradation of AXIN.
DR Reactome; R-BTA-4641258; Degradation of DVL.
DR Reactome; R-BTA-5358346; Hedgehog ligand biogenesis.
DR Reactome; R-BTA-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
DR Reactome; R-BTA-5607764; CLEC7A (Dectin-1) signaling.
DR Reactome; R-BTA-5610780; Degradation of GLI1 by the proteasome.
DR Reactome; R-BTA-5610785; GLI3 is processed to GLI3R by the proteasome.
DR Reactome; R-BTA-5632684; Hedgehog 'on' state.
DR Reactome; R-BTA-5668541; TNFR2 non-canonical NF-kB pathway.
DR Reactome; R-BTA-5676590; NIK-->noncanonical NF-kB signaling.
DR Reactome; R-BTA-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-BTA-5689603; UCH proteinases.
DR Reactome; R-BTA-5689880; Ub-specific processing proteases.
DR Reactome; R-BTA-6798695; Neutrophil degranulation.
DR Reactome; R-BTA-68867; Assembly of the pre-replicative complex.
DR Reactome; R-BTA-68949; Orc1 removal from chromatin.
DR Reactome; R-BTA-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-BTA-69481; G2/M Checkpoints.
DR Reactome; R-BTA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
DR Reactome; R-BTA-75815; Ubiquitin-dependent degradation of Cyclin D.
DR Reactome; R-BTA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
DR Reactome; R-BTA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
DR Reactome; R-BTA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-BTA-8939902; Regulation of RUNX2 expression and activity.
DR Reactome; R-BTA-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-BTA-8948751; Regulation of PTEN stability and activity.
DR Reactome; R-BTA-8951664; Neddylation.
DR Reactome; R-BTA-9020702; Interleukin-1 signaling.
DR Reactome; R-BTA-9755511; KEAP1-NFE2L2 pathway.
DR Reactome; R-BTA-9762114; GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2.
DR Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR Proteomes; UP000009136; Chromosome 15.
DR Bgee; ENSBTAG00000021744; Expressed in laryngeal cartilage and 106 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0036402; F:proteasome-activating activity; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032501; Prot_ATP_ID_OB_2nd.
DR PANTHER; PTHR23073; 26S PROTEASOME REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR23073:SF7; 26S PROTEASOME REGULATORY SUBUNIT 6A; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF16450; Prot_ATP_ID_OB_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|RuleBase:RU003651};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F1MWE0};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 220..359
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 440 AA; 49317 MW; 9D8DD01966FEDF66 CRC64;
MVNLLPKLES PVTRQEKMAT VWDEAEQDGI GEEVLKMSTE EIIQRTRLLD SEIKIMKSEV
LRVTHELQAM KDKIKENSEK IKVNKTLPYL VSNVIELLDV DPNDQEEDGA NIDLDSQRKG
KCAVIKTSTR QTYFLPVIGL VDAEKLKPGD LVGVNKDSYL ILETLPTEYD SRVKAMEVDE
RPTEQYSDIG GLDKQIQELV EAIVLPMNHK EKFENLGIQP PKGVLMYGPP GTGKTLLARA
CAAQTKATFL KLAGPQLVQM FIGDGAKLVR DAFALAKEKA PSIIFIDELD AIGTKRFDSE
KAGDREVQRT MLELLNQLDG FQPNTQVKVI AATNRVDILD PALLRSGRLD RKIEFPMPNE
EARARIMQIH SRKMNVSPDV NYEELARCTD DFNGAQCKAV CVEAGMIALR RGATELTHED
YMEGILEVQA KKKANLQYYA
//
