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Database: UniProt
Entry: F1MX21_BOVIN
LinkDB: F1MX21_BOVIN
Original site: F1MX21_BOVIN 
ID   F1MX21_BOVIN            Unreviewed;      2657 AA.
AC   F1MX21;
DT   03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   16-JAN-2019, entry version 64.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSBTAP00000047903};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSBTAP00000047903,
GN   ECO:0000313|VGNC:VGNC:30346};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000047903, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000047903, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000047903,
RC   ECO:0000313|Proteomes:UP000009136};
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
RA   Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
RA   Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000047903}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000047903};
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   EMBL; DAAA02053867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02053868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02053869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DAAA02053870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; F1MX21; -.
DR   PRIDE; F1MX21; -.
DR   Ensembl; ENSBTAT00000054653; ENSBTAP00000047903; ENSBTAG00000020455.
DR   VGNC; VGNC:30346; ITPR1.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000155071; -.
DR   OMA; PRHAPYK; -.
DR   TreeFam; TF312815; -.
DR   Reactome; R-BTA-114508; Effects of PIP2 hydrolysis.
DR   Reactome; R-BTA-139853; Elevation of cytosolic Ca2+ levels.
DR   Reactome; R-BTA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-BTA-418457; cGMP effects.
DR   Reactome; R-BTA-5578775; Ion homeostasis.
DR   Reactome; R-BTA-983695; Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
DR   Proteomes; UP000009136; Chromosome 22.
DR   Bgee; ENSBTAG00000020455; Expressed in 9 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0005955; C:calcineurin complex; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0031088; C:platelet dense granule membrane; IEA:Ensembl.
DR   GO; GO:0031094; C:platelet dense tubular network; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR   GO; GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0098695; F:inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR   GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR   GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0050882; P:voluntary musculoskeletal movement; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009136};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2182   2204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2216   2234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2303   2328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2348   2370       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2478   2501       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       58    112       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      119    169       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      177    233       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      240    319       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      325    381       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     1539   1559       {ECO:0000256|SAM:Coils}.
FT   COILED     2595   2636       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2657 AA;  302892 MW;  A828FB896702448C CRC64;
     DCLFKLCPMN RYSAQKQFWK AAKPGANSTT DAVLLNKLHH AADLEKKQNE TENRKLLGTV
     IQYGNVIQLL HLKSNKYLTV NKRLPALLEK NAMRVTLDEA GNEGSWFYIQ PFYKLRSIGD
     SVVIGDKVVL NPVNAGQPLH ASSHQLVDNP GCNEVNSVNC NTSWKIVLFM KWSDNKDDIL
     KGGDVVRLFH AEQEKFLTCD EHRKKQHVFL RTTGRQSATS ATSSKALWEV EVVQHDPCRG
     GAGYWNSLFR FKHLATGHYL AAEVDPDFEE ECLEFQPSVD PDQDASRSRL RNAQEKMVYS
     LVSVPEGNDI SSIFELDPTT LRGGDSLVPR NSYVRLRHLC TNTWVHSTNI PIDKEEEKPV
     MLKIGTSPVK EDKEAFAIVP VSPAEVRDLD FANDASKVLG SIAGKLEKGT ITQNERRSVT
     KLLEDLVYFV TGGTNSGQDV LEVVFSKPNR ERQKLMREQN ILKQIFKLLQ APFTDCGDGP
     MLRLEELGDQ RHAPFRHICR LCYRVLRHSQ QDYRKNQEYI AKQFGFMQKQ IGYDVLAEDT
     ITALLHNNRK LLEKHITAAE IDTFVSLVRK NREPRFLDYL SDLCVSMNKS IPVTQELICK
     AVLNPTNADI LIETKLVLSR FEFEGVSTGE NALEAGEDEE EVWLFWRDSN KEVRSKSVRE
     LAQDAKEGQK EDRDVLGYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP
     YDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSEI AIDDYDSSGT SKDEIKERFA
     QTMEFVEEYL RDVVCQRFPF SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI
     LDCVHVTTIF PISKMAKGEE NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPTATAPEGN
     VKQAEPEKED IMVMDTKLKI IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG
     NSSQEGPSNV PGALDFEHIE EQAEGIFGGR KENTPLDLDD HGGRTFLRVL LHLTMHDYPP
     LVSGALQLLF RHFSQRQEVL QAFKQVQLLV TSQDVDNYKQ IKQDLDQLRS IVEKSELWVY
     KGQGPDEAMD GASGENEHKK TEEGNNKSQQ HESTSSYNYR VVKEILIRLS KLCVQESASV
     RKSRKQQQRL LRNMGAHAVV LELLQIPYEK AEDTKMQEIM RLAHEFLQNF CAGNQQNQAL
     LHKHINLFLN PGILEAVTMQ HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT
     IVKAEGKFIK KCQDMVMAEL VNSGEDVLVF YNDRASFQTL IQMMRSERDR MDENSPLMYH
     IHLVELLAVC TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE
     VEMKEIYTSN HMWKLFENFL VDICRACNNT SDRKHADSIL EKYVTEIVMS IVTTFFSSPF
     SDQSTTLQTR QPVFVQLLQG VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL
     DSQVNNLFLK SHNLVQKTAM NWRLTARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL
     RPLVQAELSV LVDVLHRPEL LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV
     LQTLREMMTK DRGYGEKGEA LRQILVNRYY GNIRPSGRRE SLTSFGNGPL SPGGPSKPGG
     GGGGSGSSPM SRGEMSLAEV QCHLDKEGAS NLVIDLIMNA SSDRVFHESI LLAIALLEGG
     NTTIQHSFFC RLTEDKKSEK FFKVFYDRMK VAQQEIKATV TVNTSDLGNK KKDDEVDRDA
     PSRKKAKEPA TQITEEVRDQ LLEASAATRK AFTTFRREAD PDDHYQSGEG AQAAADKSKD
     DLEMSAVITI MQPILRFLQL LCENHNRDLQ NFLRCQNNKT NYNLVCETLQ FLDCICGSTT
     GGLGLLGLYI NEKNVALINQ TLESLTEYCQ GPCHENQNCI ATHESNGIDI ITALILNDIN
     PLGKKRMDLV LELKAMNNAS KLLLAIMESR HDSENAERIL YNMRPKELVE VIKKAYMQGE
     VEFEDGENGE DGAASPRNVG HNIYILAHQL ARHNKELQTM LKPGGQVDGD EALEFYAKHT
     AQIEIVRLDR TMEQIVFPVP SICEFLTKES KLRIYYTTER DEQGSKINDF FLRSEDLFNE
     MNWQKKLRAQ PVLYWCARNM SFWSSISFNL AVLMNLLVAF FYPFKGVRGG TLEPHWSGLL
     WTAMLISLAI VIALPKPHGI RALIASTILR LIFSVGLQPT LFLLGAFNVC NKIIFLMSFV
     GNCGTFTRGY RAMVLDVEFL YHLLYLLICA MGLFVHEFFY SLLLFDLVYR EETLLNVIKS
     VTRNGRSIIL TAVLALILVY LFSIVGYLFF KDDFILEVDR LPNETSLPEA SESLASEFLY
     SDVCRVETGE NCSSPAPKEE LVPAEETEQD KEHTCETLLM CIVTVLSHGL RSGGGVGDVL
     RKPSKEEPLF AARVIYDLLF FFMVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI
     CGLERDKFDN KTVTFEEHIK EEHNMWHYLC FIVLVKVKDS TEYTGPESYV AEMIKERNLD
     WFPRMRAMSL VSSDSEGEQN ELRNLQEKLE STMKLVTNLS GQLSELKDQM TEQRKQKQRI
     GLLGHPPHMN VNPQQPA
//
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