ID F1MX23_BOVIN Unreviewed; 347 AA.
AC F1MX23;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=SH3 domain containing GRB2 like 3, endophilin A3 {ECO:0000313|Ensembl:ENSBTAP00000023954.6};
GN Name=SH3GL3 {ECO:0000313|Ensembl:ENSBTAP00000023954.6,
GN ECO:0000313|VGNC:VGNC:34574};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000023954.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000023954.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023954.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000023954.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023954.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the endophilin family.
CC {ECO:0000256|ARBA:ARBA00006697}.
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DR RefSeq; XP_010815341.1; XM_010817039.2.
DR RefSeq; XP_010823171.1; XM_010824869.2.
DR AlphaFoldDB; F1MX23; -.
DR SMR; F1MX23; -.
DR STRING; 9913.ENSBTAP00000023954; -.
DR PaxDb; 9913-ENSBTAP00000023954; -.
DR Ensembl; ENSBTAT00000023954.6; ENSBTAP00000023954.6; ENSBTAG00000018004.6.
DR GeneID; 520311; -.
DR CTD; 6457; -.
DR VEuPathDB; HostDB:ENSBTAG00000018004; -.
DR VGNC; VGNC:34574; SH3GL3.
DR eggNOG; KOG1118; Eukaryota.
DR GeneTree; ENSGT00940000157398; -.
DR HOGENOM; CLU_047887_0_0_1; -.
DR InParanoid; F1MX23; -.
DR OMA; NFLENDX; -.
DR TreeFam; TF313281; -.
DR Reactome; R-BTA-182971; EGFR downregulation.
DR Reactome; R-BTA-6807004; Negative regulation of MET activity.
DR Reactome; R-BTA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-BTA-8856828; Clathrin-mediated endocytosis.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000018004; Expressed in floor plate of diencephalon and 100 other cell types or tissues.
DR ExpressionAtlas; F1MX23; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0016191; P:synaptic vesicle uncoating; IBA:GO_Central.
DR CDD; cd07615; BAR_Endophilin_A3; 1.
DR CDD; cd11803; SH3_Endophilin_A; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR032469; Endophilin-A3_BAR.
DR InterPro; IPR035824; Endophilin_A_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14167:SF45; ENDOPHILIN-A3; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 18..249
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 285..344
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 251..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 39123 MW; CE7C9BBF2CDC102B CRC64;
MSVAGLKKQF HKASQLFSEK ISGVEGTKLD DEFLDMERKI DITNKAVAEI LSKATEYLQP
NPAYRAKLGM LNTMSKIRGQ VKTTGYPQTE GLLGDCMLKY GKELGEGSTF GSALIEVGES
MKLMAEVKDS LDINVKQTFI DPLQLLQDKD LKEIGHHLKK LEGRRLDYDY KKKRVGKIPD
EEVRQAVEKF EESKELAERS MFNFLENDVE QVSQLAVFVE AALDYHRQST EILQELQSKL
QMRISAASNV PKREYKPRPI KRSPSELNGV STASSAKTTG SNVPMDQPCC RGLYDFEPEN
QGELGFKEGD IITLTNQIDE NWYEGILHGE SGFFPINYVE VIVPLPQ
//
