ID F1MY57_BOVIN Unreviewed; 651 AA.
AC F1MY57;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Sodium channel epithelial 1 subunit delta {ECO:0000313|Ensembl:ENSBTAP00000023511.5};
GN Name=SCNN1D {ECO:0000313|Ensembl:ENSBTAP00000023511.5,
GN ECO:0000313|VGNC:VGNC:34357};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000023511.5, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000023511.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023511.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000023511.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000023511.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; F1MY57; -.
DR STRING; 9913.ENSBTAP00000023511; -.
DR PaxDb; 9913-ENSBTAP00000023511; -.
DR Ensembl; ENSBTAT00000023511.5; ENSBTAP00000023511.5; ENSBTAG00000017674.5.
DR VEuPathDB; HostDB:ENSBTAG00000017674; -.
DR VGNC; VGNC:34357; SCNN1D.
DR eggNOG; KOG4294; Eukaryota.
DR GeneTree; ENSGT00940000162685; -.
DR HOGENOM; CLU_020415_0_2_1; -.
DR InParanoid; F1MY57; -.
DR OMA; RFHYVDI; -.
DR TreeFam; TF330663; -.
DR Reactome; R-BTA-2672351; Stimuli-sensing channels.
DR Reactome; R-BTA-9730628; Sensory perception of salty taste.
DR Proteomes; UP000009136; Chromosome 16.
DR Bgee; ENSBTAG00000017674; Expressed in pons and 86 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034706; C:sodium channel complex; IBA:GO_Central.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF132; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT DELTA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 87..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 16..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 651 AA; 72639 MW; CDCA10D4622DB0B7 CRC64;
MDAHAQGGCS LEMQAEGTGQ TVGGGPGTWT CPQASPPTLP EEEHGERLVE LHASFRELVT
FFCTNSTIHG TIRLVCSSQN RLKTASWGLL LAGALGVLYW QFALLFEQYW RYPVIMTVSV
HSERKLFPSV TLCDMNPHRP HLARHHLRVL DDFARESIYS LYRFNFSDSM DALGAEVPGP
EPAFHLDRRI RLQRLRPLDG QNRVGFKLCN STGGDCVERA YSSGVVAARE WYRFHYINIL
ALLPAAHEDS HGSHFVFSCR YDDRDCHAQH FQTSHHPTYG SCYTFNGVWA AQRPGVTHRI
SLVLRAEQLD HLPLLSTKAG IKVMIHPQDH TPFLEHQGFS IRPGTETTID IREDEVHRLG
SPYGQCMDST GSVDVQLLYN TSYTRQACLV SCFQHLMVET CSCGYFFYPL PAGAEYCSYM
RHPAWGHCFH HLYQKLKTHQ LPCTTRCPRP CRESSYKLSA GTSRWPSSTS ADWVLAVLGE
PSRRNPWPSS ASIKSWPLPL PSSPSRARTE GPTSRSGAQP LSPEPCPSIS LAKVNIFYQE
LNYRTVDETP VYSVPQLLSA MGSLWSLWFG SSVLSVVEVL ELLLDAIALT LLLCCRWLCG
SRGQPRAATR VHPPSQRPAS GPVAADTTSN APGPGCLHLP RCCRDFSRSL G
//
