ID F1MYH2_BOVIN Unreviewed; 463 AA.
AC F1MYH2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=E2F transcription factor 3 {ECO:0000313|Ensembl:ENSBTAP00000028030.4};
GN Name=E2F3 {ECO:0000313|Ensembl:ENSBTAP00000028030.4,
GN ECO:0000313|VGNC:VGNC:28287};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000028030.4, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000028030.4, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028030.4,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000028030.4}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028030.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR RefSeq; NP_001179767.1; NM_001192838.1.
DR AlphaFoldDB; F1MYH2; -.
DR SMR; F1MYH2; -.
DR STRING; 9913.ENSBTAP00000028030; -.
DR PaxDb; 9913-ENSBTAP00000028030; -.
DR Ensembl; ENSBTAT00000028030.5; ENSBTAP00000028030.4; ENSBTAG00000021045.5.
DR GeneID; 541184; -.
DR KEGG; bta:541184; -.
DR CTD; 1871; -.
DR VEuPathDB; HostDB:ENSBTAG00000021045; -.
DR VGNC; VGNC:28287; E2F3.
DR eggNOG; KOG2577; Eukaryota.
DR GeneTree; ENSGT00940000155115; -.
DR HOGENOM; CLU_032091_0_0_1; -.
DR InParanoid; F1MYH2; -.
DR OMA; WMGCNLS; -.
DR OrthoDB; 1761at2759; -.
DR TreeFam; TF105566; -.
DR Reactome; R-BTA-68911; G2 Phase.
DR Reactome; R-BTA-69231; Cyclin D associated events in G1.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000021045; Expressed in neutrophil and 104 other cell types or tissues.
DR ExpressionAtlas; F1MYH2; baseline and differential.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0070345; P:negative regulation of fat cell proliferation; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1905461; P:positive regulation of vascular associated smooth muscle cell apoptotic process; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd14660; E2F_DD; 1.
DR Gene3D; 6.10.250.540; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR037241; E2F-DP_heterodim.
DR InterPro; IPR032198; E2F_CC-MB.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF44; TRANSCRIPTION FACTOR E2F3; 1.
DR Pfam; PF16421; E2F_CC-MB; 1.
DR Pfam; PF02319; E2F_TDP; 1.
DR SMART; SM01372; E2F_TDP; 1.
DR SUPFAM; SSF144074; E2F-DP heterodimerization region; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 176..241
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 95..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 49133 MW; BAEC783A33F971B9 CRC64;
MRKGIQPALE QYLVTAGGGE GAAVVAAAAA ASMDKRALLA SPGFPAAAAA APSAYIQILT
TNTSTTSCSS SLQSGAVAAG PLLPSAPGVE QTAGSLIYTT PHGPSGRAGL LQQPPALGRG
GSGGGGGPPA KRRLELGESG QQYLSDGLKT PKGKGRAALR SPDSPKTPKS PSEKTRYDTS
LGLLTKKFIQ LLSQSPDGVL DLNKAAEVLK VQKRRIYDIT NVLEGIHLIK KKSKNNVQWM
GCSLSEDGGM LAQCQGLSKE VTELSQEEKK LDELIQSCTL DLKLLTEDSE NQRLAYVTYQ
DIRKISGLKD QTVIVVKAPP ETRLEVPDPI ESLQIHLAST QGPIEVYLCP EETETHSPMK
TNNQDHNGNI PKPTSKDLAS TNSGHSDCSI SMANLSPLAS PANLLQQTED QIPSNLEGPF
VNLLPPLLQE DYLLSLGEEE GISDLFDAYD LEKLPLVEDF MCS
//
