ID F1MZC2_BOVIN Unreviewed; 381 AA.
AC F1MZC2;
DT 03-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 3.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=ArfGAP with dual PH domains 2 {ECO:0000313|Ensembl:ENSBTAP00000004328.6};
GN Name=ADAP2 {ECO:0000313|Ensembl:ENSBTAP00000004328.6,
GN ECO:0000313|VGNC:VGNC:25634};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000004328.6, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000004328.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004328.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000004328.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000004328.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F1MZC2; -.
DR SMR; F1MZC2; -.
DR STRING; 9913.ENSBTAP00000004328; -.
DR PaxDb; 9913-ENSBTAP00000004328; -.
DR Ensembl; ENSBTAT00000004328.6; ENSBTAP00000004328.6; ENSBTAG00000003334.6.
DR VEuPathDB; HostDB:ENSBTAG00000003334; -.
DR VGNC; VGNC:25634; ADAP2.
DR eggNOG; KOG0703; Eukaryota.
DR GeneTree; ENSGT00940000156498; -.
DR HOGENOM; CLU_061583_0_0_1; -.
DR InParanoid; F1MZC2; -.
DR OMA; CAKAKYE; -.
DR OrthoDB; 1022106at2759; -.
DR TreeFam; TF324540; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000003334; Expressed in monocyte and 100 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0043533; F:inositol 1,3,4,5 tetrakisphosphate binding; IEA:Ensembl.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IBA:GO_Central.
DR CDD; cd08844; ArfGap_ADAP2; 1.
DR CDD; cd13252; PH1_ADAP; 1.
DR CDD; cd01251; PH2_ADAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037849; PH1_ADAP.
DR InterPro; IPR037851; PH2_ADAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR PANTHER; PTHR46021:SF6; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 9..136
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 132..233
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 255..361
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 381 AA; 44396 MW; 09F6E7181D1ACC1C CRC64;
MGDRERNKKR LLELLQAAGT GNAYCADCGA ADPDWASYKL GIFICLNCSG VHRNFPDISK
VKSVRLDFWD DSIVEFMTHN GNLRVKTKYE ARVPAFYYIP QANDCMVLKE QWIRAKYERQ
EFMADGKTIS PPGNREGFLW KRGRDNAQFL KRRFVLLARE GLLKYYTKEE GKDPKAVISI
KDLNATFQTE KIGNPHGLQI TYRRDGRVRN LFVYHENGKE IVDWFNALRA ARLQYLKMAF
PELPESELVP LITRNYLKQG FMEKTGPKQR EPFKKRWFAL DPQERRLLYY KNPLDAFELG
QVFLGSNEQG YQVFEDLPKG IRGNRWKAGL TIVTPHRRFV FTCPSEKEQR EWLESFREVL
SSPLTPLNLL AVSTESDCSH R
//
